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pH Dependence of T1 for 13 C-Labelled Small Molecules Commonly Used for Hyperpolarized Magnetic Resonance Imaging.
Chemphyschem. 2019 03 18; 20(6):798-802.C

Abstract

Hyperpolarization is a method to enhance the nuclear magnetic resonance signal by up to five orders of magnitude. However, the hyperpolarized (HP) state is transient and decays with the spin-lattice relaxation time (T1), which is on the order of a few tens of seconds. Here, we analyzed the pH-dependence of T1 for commonly used HP 13 C-labelled small molecules such as acetate, alanine, fumarate, lactate, pyruvate, urea and zymonic acid. For instance, the T1 of HP pyruvate is about 2.5 fold smaller at acidic pH (25 s, pH 1.7, B0 =1 T) compared to pH close to physiological conditions (66 s, pH 7.3, B0 =1 T). Our data shows that increasing hydronium ion concentrations shorten the T1 of protonated carboxylic acids of most of the analyzed molecules except lactate. Furthermore it suggests that intermolecular hydrogen bonding at low pH can contribute to this T1 shortening. In addition, enhanced proton exchange and chemical reactions at the pKa appear to be detrimental for the HP-state.

Authors+Show Affiliations

Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich. Department of Chemistry, Technical University of Munich, Lichtenbergstraβe 4, 85748, Garching. Graduate School of Bioengineering, Technical University of Munich, Boltzmannstr. 11, 85748, Garching.Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich.Department of Chemistry, Technical University of Munich, Lichtenbergstraβe 4, 85748, Garching.Department of Chemistry, Technical University of Munich, Lichtenbergstraβe 4, 85748, Garching.Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30790394

Citation

Hundshammer, Christian, et al. "PH Dependence of T1 for 13 C-Labelled Small Molecules Commonly Used for Hyperpolarized Magnetic Resonance Imaging." Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry, vol. 20, no. 6, 2019, pp. 798-802.
Hundshammer C, Grashei M, Greiner A, et al. PH Dependence of T1 for 13 C-Labelled Small Molecules Commonly Used for Hyperpolarized Magnetic Resonance Imaging. Chemphyschem. 2019;20(6):798-802.
Hundshammer, C., Grashei, M., Greiner, A., Glaser, S. J., & Schilling, F. (2019). PH Dependence of T1 for 13 C-Labelled Small Molecules Commonly Used for Hyperpolarized Magnetic Resonance Imaging. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry, 20(6), 798-802. https://doi.org/10.1002/cphc.201801098
Hundshammer C, et al. PH Dependence of T1 for 13 C-Labelled Small Molecules Commonly Used for Hyperpolarized Magnetic Resonance Imaging. Chemphyschem. 2019 03 18;20(6):798-802. PubMed PMID: 30790394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - pH Dependence of T1 for 13 C-Labelled Small Molecules Commonly Used for Hyperpolarized Magnetic Resonance Imaging. AU - Hundshammer,Christian, AU - Grashei,Martin, AU - Greiner,Alexandra, AU - Glaser,Steffen J, AU - Schilling,Franz, Y1 - 2019/02/21/ PY - 2018/11/25/received PY - 2019/02/07/revised PY - 2019/2/23/pubmed PY - 2019/2/23/medline PY - 2019/2/22/entrez KW - T1 KW - hyperpolarization KW - magnetic resonance imaging KW - nuclear magnetic resonance KW - pH dependence SP - 798 EP - 802 JF - Chemphyschem : a European journal of chemical physics and physical chemistry JO - Chemphyschem VL - 20 IS - 6 N2 - Hyperpolarization is a method to enhance the nuclear magnetic resonance signal by up to five orders of magnitude. However, the hyperpolarized (HP) state is transient and decays with the spin-lattice relaxation time (T1), which is on the order of a few tens of seconds. Here, we analyzed the pH-dependence of T1 for commonly used HP 13 C-labelled small molecules such as acetate, alanine, fumarate, lactate, pyruvate, urea and zymonic acid. For instance, the T1 of HP pyruvate is about 2.5 fold smaller at acidic pH (25 s, pH 1.7, B0 =1 T) compared to pH close to physiological conditions (66 s, pH 7.3, B0 =1 T). Our data shows that increasing hydronium ion concentrations shorten the T1 of protonated carboxylic acids of most of the analyzed molecules except lactate. Furthermore it suggests that intermolecular hydrogen bonding at low pH can contribute to this T1 shortening. In addition, enhanced proton exchange and chemical reactions at the pKa appear to be detrimental for the HP-state. SN - 1439-7641 UR - https://www.unboundmedicine.com/medline/citation/30790394/pH_Dependence_of_T1_for_13_C-Labelled_Small_Molecules_Commonly_Used_for_Hyperpolarized_Magnetic_Resonance_Imaging L2 - https://doi.org/10.1002/cphc.201801098 DB - PRIME DP - Unbound Medicine ER -
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