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Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment.
Graefes Arch Clin Exp Ophthalmol. 2019 Apr; 257(4):733-740.GA

Abstract

PURPOSE

To explore macular perfusion changes in patients with rhegmatogenous retinal detachment (RRD) involved the macula following successful surgery and to evaluate the correlation between macular blood flow density and visual outcomes using optical coherence tomography angiography (OCTA).

METHODS

This retrospective study included 14 eyes (14 patients) with macular-off RRD that underwent a standard three-port 23-gauge pars plana vitrectomy (PPV) and intraocular gas tamponade combined with phacoemulsification, aspiration, and intraocular lens implantation. OCTA was used to evaluate the macular perfusion changes throughout postoperative 12 weeks in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillary plexus (CCP). The fellow unaffected eyes were used as controls for comparison.

RESULTS

A significant increase in the superficial capillary plexus flow density (SCPFD) (P = 0.000) was observed over time in RRD eyes with successful PPV, as well as the deep capillary plexus flow density (DCPFD) (P = 0.000) and the choriocapillary plexus flow density (CCPFD) (P = 0.000). Final best-corrected visual acuity (BCVA) was positively associated with CCPFD (r = - 0.577, P = 0.031) and non-correlated with SCPFD and DCPFD (P > 0.05).

CONCLUSIONS

Macular perfusion gradually recovered following successful RRD repair by PPV. OCTA provided a non-invasive method to explore the underlying reason for different postoperative visual outcomes in macular-off RRD patients.

Authors+Show Affiliations

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China. drsuntao@yeah.net. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. drsuntao@yeah.net. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. drsuntao@yeah.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30796563

Citation

Wang, Hong, et al. "Macular Perfusion Changes Assessed With Optical Coherence Tomography Angiography After Vitrectomy for Rhegmatogenous Retinal Detachment." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 257, no. 4, 2019, pp. 733-740.
Wang H, Xu X, Sun X, et al. Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2019;257(4):733-740.
Wang, H., Xu, X., Sun, X., Ma, Y., & Sun, T. (2019). Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 257(4), 733-740. https://doi.org/10.1007/s00417-019-04273-7
Wang H, et al. Macular Perfusion Changes Assessed With Optical Coherence Tomography Angiography After Vitrectomy for Rhegmatogenous Retinal Detachment. Graefes Arch Clin Exp Ophthalmol. 2019;257(4):733-740. PubMed PMID: 30796563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment. AU - Wang,Hong, AU - Xu,Xun, AU - Sun,Xiaodong, AU - Ma,Yingyan, AU - Sun,Tao, Y1 - 2019/02/22/ PY - 2018/11/04/received PY - 2019/02/11/accepted PY - 2019/01/31/revised PY - 2019/2/24/pubmed PY - 2019/4/13/medline PY - 2019/2/24/entrez KW - Choriocapillary plexus KW - Macular perfusion KW - Optical coherence tomography angiography KW - Retinal capillary plexus KW - Rhegmatogenous retinal detachment SP - 733 EP - 740 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch. Clin. Exp. Ophthalmol. VL - 257 IS - 4 N2 - PURPOSE: To explore macular perfusion changes in patients with rhegmatogenous retinal detachment (RRD) involved the macula following successful surgery and to evaluate the correlation between macular blood flow density and visual outcomes using optical coherence tomography angiography (OCTA). METHODS: This retrospective study included 14 eyes (14 patients) with macular-off RRD that underwent a standard three-port 23-gauge pars plana vitrectomy (PPV) and intraocular gas tamponade combined with phacoemulsification, aspiration, and intraocular lens implantation. OCTA was used to evaluate the macular perfusion changes throughout postoperative 12 weeks in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillary plexus (CCP). The fellow unaffected eyes were used as controls for comparison. RESULTS: A significant increase in the superficial capillary plexus flow density (SCPFD) (P = 0.000) was observed over time in RRD eyes with successful PPV, as well as the deep capillary plexus flow density (DCPFD) (P = 0.000) and the choriocapillary plexus flow density (CCPFD) (P = 0.000). Final best-corrected visual acuity (BCVA) was positively associated with CCPFD (r = - 0.577, P = 0.031) and non-correlated with SCPFD and DCPFD (P > 0.05). CONCLUSIONS: Macular perfusion gradually recovered following successful RRD repair by PPV. OCTA provided a non-invasive method to explore the underlying reason for different postoperative visual outcomes in macular-off RRD patients. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/30796563/Macular_perfusion_changes_assessed_with_optical_coherence_tomography_angiography_after_vitrectomy_for_rhegmatogenous_retinal_detachment_ L2 - https://dx.doi.org/10.1007/s00417-019-04273-7 DB - PRIME DP - Unbound Medicine ER -