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Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO.
J Immunol. 1986 Jan; 136(2):716-9.JI

Abstract

The complete amino acid sequence of the human monoclonal lambda VI light chain Bence Jones protein THO was determined. We have found it to have remarkable similarities to the previously sequenced lambda VI Bence Jones protein SUT. Immunochemical analyses demonstrated that both lambda VI chains belong to a V lambda VI sub-subgroup. The 98-residue V gene-encoded segments of proteins THO and SUT are closely homologous and are distinguished from other lambda VI chains by a one-residue deletion at the V-J recombination site. Proteins THO and SUT have identical 13-residue J segments and therefore are encoded by the same J lambda gene. Further, both proteins have identical 105-residue C regions that by sequence represent products of the C lambda 3 (Kern-, Oz+) gene. The primary structure and serologic properties of proteins THO and SUT imply at the protein level of association between certain types of V lambda, J lambda, and C lambda segments.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3079791

Citation

Ghiso, J, et al. "Association of Human Lambda Light Chain V/J/C Segments: Serologic Analysis and Primary Structure of the Lambda VI Bence Jones Protein THO." Journal of Immunology (Baltimore, Md. : 1950), vol. 136, no. 2, 1986, pp. 716-9.
Ghiso J, Solomon A, Frangione B. Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO. J Immunol. 1986;136(2):716-9.
Ghiso, J., Solomon, A., & Frangione, B. (1986). Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO. Journal of Immunology (Baltimore, Md. : 1950), 136(2), 716-9.
Ghiso J, Solomon A, Frangione B. Association of Human Lambda Light Chain V/J/C Segments: Serologic Analysis and Primary Structure of the Lambda VI Bence Jones Protein THO. J Immunol. 1986;136(2):716-9. PubMed PMID: 3079791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO. AU - Ghiso,J, AU - Solomon,A, AU - Frangione,B, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 716 EP - 9 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 136 IS - 2 N2 - The complete amino acid sequence of the human monoclonal lambda VI light chain Bence Jones protein THO was determined. We have found it to have remarkable similarities to the previously sequenced lambda VI Bence Jones protein SUT. Immunochemical analyses demonstrated that both lambda VI chains belong to a V lambda VI sub-subgroup. The 98-residue V gene-encoded segments of proteins THO and SUT are closely homologous and are distinguished from other lambda VI chains by a one-residue deletion at the V-J recombination site. Proteins THO and SUT have identical 13-residue J segments and therefore are encoded by the same J lambda gene. Further, both proteins have identical 105-residue C regions that by sequence represent products of the C lambda 3 (Kern-, Oz+) gene. The primary structure and serologic properties of proteins THO and SUT imply at the protein level of association between certain types of V lambda, J lambda, and C lambda segments. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/3079791/Association_of_human_lambda_light_chain_V/J/C_segments:_serologic_analysis_and_primary_structure_of_the_lambda_VI_Bence_Jones_protein_THO_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=3079791 DB - PRIME DP - Unbound Medicine ER -