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Diagnosing and managing bronchiolitis obliterans in children.
Expert Rev Respir Med 2019; 13(5):481-488ER

Abstract

INTRODUCTION

Bronchiolitis obliterans (BO) is a chronic and irreversible obstructive lung disease leading to the obstruction and/or obliteration of the small airways. Three main BO entities are distinguished: post-infectious BO (PIBO); BO post lung transplantation; and BO after bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT). All three entities are separate, however, there are similarities in histopathological characteristics and possibly in aspects of the development pathway. Areas covered: We review current evidence of bronchiolitis obliterans diagnosis and management in children. The diagnosis of BO is usually based on a combination of history, clinical and radiological findings, although lung biopsy and histopathology remain the gold standard approaches to confirm BO. Expert opinion: At present, we do not have a clear understanding of the mechanisms of the development of BO and lack strong evidence for treatment. Although most BO in children is post-infectious, most of the current evidence for treatment originates from studies analyzing BO in adult lung transplant and HSCT patients. BO management requires multidisciplinary approach and care in specialized centers.

Authors+Show Affiliations

a Respiratory Unit , Great Ormond Street Hospital for Children NHS Foundation Trust , London , UK.a Respiratory Unit , Great Ormond Street Hospital for Children NHS Foundation Trust , London , UK. b Respiratory Critical Care and Anaesthesia Section , Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health , London , UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30798629

Citation

Kavaliunaite, Ema, and Paul Aurora. "Diagnosing and Managing Bronchiolitis Obliterans in Children." Expert Review of Respiratory Medicine, vol. 13, no. 5, 2019, pp. 481-488.
Kavaliunaite E, Aurora P. Diagnosing and managing bronchiolitis obliterans in children. Expert Rev Respir Med. 2019;13(5):481-488.
Kavaliunaite, E., & Aurora, P. (2019). Diagnosing and managing bronchiolitis obliterans in children. Expert Review of Respiratory Medicine, 13(5), pp. 481-488. doi:10.1080/17476348.2019.1586537.
Kavaliunaite E, Aurora P. Diagnosing and Managing Bronchiolitis Obliterans in Children. Expert Rev Respir Med. 2019;13(5):481-488. PubMed PMID: 30798629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosing and managing bronchiolitis obliterans in children. AU - Kavaliunaite,Ema, AU - Aurora,Paul, Y1 - 2019/03/08/ PY - 2019/2/26/pubmed PY - 2019/2/26/medline PY - 2019/2/26/entrez KW - Bronchiolitis obliterans KW - bronchiolitis obliterans syndrome KW - children SP - 481 EP - 488 JF - Expert review of respiratory medicine JO - Expert Rev Respir Med VL - 13 IS - 5 N2 - INTRODUCTION: Bronchiolitis obliterans (BO) is a chronic and irreversible obstructive lung disease leading to the obstruction and/or obliteration of the small airways. Three main BO entities are distinguished: post-infectious BO (PIBO); BO post lung transplantation; and BO after bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT). All three entities are separate, however, there are similarities in histopathological characteristics and possibly in aspects of the development pathway. Areas covered: We review current evidence of bronchiolitis obliterans diagnosis and management in children. The diagnosis of BO is usually based on a combination of history, clinical and radiological findings, although lung biopsy and histopathology remain the gold standard approaches to confirm BO. Expert opinion: At present, we do not have a clear understanding of the mechanisms of the development of BO and lack strong evidence for treatment. Although most BO in children is post-infectious, most of the current evidence for treatment originates from studies analyzing BO in adult lung transplant and HSCT patients. BO management requires multidisciplinary approach and care in specialized centers. SN - 1747-6356 UR - https://www.unboundmedicine.com/medline/citation/30798629/Diagnosing_and_managing_bronchiolitis_obliterans_in_children_ L2 - http://www.tandfonline.com/doi/full/10.1080/17476348.2019.1586537 DB - PRIME DP - Unbound Medicine ER -