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Evaluation of an osteochondral fragment-groove procedure for induction of metacarpophalangeal joint osteoarthritis in horses.
Am J Vet Res. 2019 Mar; 80(3):246-258.AJ

Abstract

OBJECTIVE

To evaluate lameness and morphological changes associated with an osteochondral fragment-groove procedure as a means of experimental induction of metacarpophalangeal (MCP) joint osteoarthritis within an 11-week period in horses. ANIMALS 6 nonlame adult warmbloods. PROCEDURES The right MCP joint of each horse underwent an osteochondral fragment-groove procedure (day 0). After 1 week of stall rest (ie, starting day 7), each horse was trained daily on a treadmill. Weekly, horses underwent visual and inertial sensor-based assessments of lameness. Both MCP joints were assessed radiographically on days 0 (before surgery), 1, 35, and 77. A synovial fluid sample was collected from the right MCP joint on days 0 (before surgery), 35, 36, 49, 63, and 77 for cytologic and biomarker analyses. On day 77, each horse was euthanized; both MCP joints were evaluated macroscopically and histologically.

RESULTS

Right forelimb lameness was detected visually and by the inertial sensor system when horses were moving on a straight line after distal forelimb flexion or circling left on days 14 to 77. Compared with presurgical values, synovial fluid interleukin-6, prostaglandin E2, hyaluronic acid, and interleukin-1 receptor antagonist protein concentrations were increased at 2 or 3 time points, whereas tumor necrosis factor-α and interleukin-10 concentrations were decreased at 1 time point. Gross examination of all right MCP joints revealed synovitis and wear lines; synovitis was confirmed histologically.

CONCLUSIONS

AND CLINICAL RELEVANCE Results indicated that a combined osteochondral fragment-groove procedure can be used to induce clinically and grossly observable early MCP joint osteoarthritis during an 11-week period in horses.

Authors

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Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

30801207

Citation

Broeckx, Sarah Y., et al. "Evaluation of an Osteochondral Fragment-groove Procedure for Induction of Metacarpophalangeal Joint Osteoarthritis in Horses." American Journal of Veterinary Research, vol. 80, no. 3, 2019, pp. 246-258.
Broeckx SY, Pille F, Buntinx S, et al. Evaluation of an osteochondral fragment-groove procedure for induction of metacarpophalangeal joint osteoarthritis in horses. Am J Vet Res. 2019;80(3):246-258.
Broeckx, S. Y., Pille, F., Buntinx, S., Van Brantegem, L., Duchateau, L., Oosterlinck, M., Chiers, K., Bertone, A. L., Spaas, J. H., & Martens, A. M. (2019). Evaluation of an osteochondral fragment-groove procedure for induction of metacarpophalangeal joint osteoarthritis in horses. American Journal of Veterinary Research, 80(3), 246-258. https://doi.org/10.2460/ajvr.80.3.246
Broeckx SY, et al. Evaluation of an Osteochondral Fragment-groove Procedure for Induction of Metacarpophalangeal Joint Osteoarthritis in Horses. Am J Vet Res. 2019;80(3):246-258. PubMed PMID: 30801207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of an osteochondral fragment-groove procedure for induction of metacarpophalangeal joint osteoarthritis in horses. AU - Broeckx,Sarah Y, AU - Pille,Frederik, AU - Buntinx,Simon, AU - Van Brantegem,Leen, AU - Duchateau,Luc, AU - Oosterlinck,Maarten, AU - Chiers,Koen, AU - Bertone,Alicia L, AU - Spaas,Jan H, AU - Martens,Ann M, PY - 2019/2/26/entrez PY - 2019/2/26/pubmed PY - 2019/4/4/medline SP - 246 EP - 258 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 80 IS - 3 N2 - OBJECTIVE To evaluate lameness and morphological changes associated with an osteochondral fragment-groove procedure as a means of experimental induction of metacarpophalangeal (MCP) joint osteoarthritis within an 11-week period in horses. ANIMALS 6 nonlame adult warmbloods. PROCEDURES The right MCP joint of each horse underwent an osteochondral fragment-groove procedure (day 0). After 1 week of stall rest (ie, starting day 7), each horse was trained daily on a treadmill. Weekly, horses underwent visual and inertial sensor-based assessments of lameness. Both MCP joints were assessed radiographically on days 0 (before surgery), 1, 35, and 77. A synovial fluid sample was collected from the right MCP joint on days 0 (before surgery), 35, 36, 49, 63, and 77 for cytologic and biomarker analyses. On day 77, each horse was euthanized; both MCP joints were evaluated macroscopically and histologically. RESULTS Right forelimb lameness was detected visually and by the inertial sensor system when horses were moving on a straight line after distal forelimb flexion or circling left on days 14 to 77. Compared with presurgical values, synovial fluid interleukin-6, prostaglandin E2, hyaluronic acid, and interleukin-1 receptor antagonist protein concentrations were increased at 2 or 3 time points, whereas tumor necrosis factor-α and interleukin-10 concentrations were decreased at 1 time point. Gross examination of all right MCP joints revealed synovitis and wear lines; synovitis was confirmed histologically. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that a combined osteochondral fragment-groove procedure can be used to induce clinically and grossly observable early MCP joint osteoarthritis during an 11-week period in horses. SN - 1943-5681 UR - https://www.unboundmedicine.com/medline/citation/30801207/Evaluation_of_an_osteochondral_fragment_groove_procedure_for_induction_of_metacarpophalangeal_joint_osteoarthritis_in_horses_ L2 - http://avmajournals.avma.org/doi/full/10.2460/ajvr.80.3.246?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -