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The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities.
J Biochem Mol Toxicol. 2019 Jun; 33(6):e22313.JB

Abstract

Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used. The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Solhan, School of Health Services, Bingol University, Bingol, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, Bingol, Turkey.Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30801880

Citation

Taslimi, Parham, et al. "The Antidiabetic and Anticholinergic Effects of Chrysin On Cyclophosphamide-induced Multiple Organ Toxicity in Rats: Pharmacological Evaluation of some Metabolic Enzyme Activities." Journal of Biochemical and Molecular Toxicology, vol. 33, no. 6, 2019, pp. e22313.
Taslimi P, Kandemir FM, Demir Y, et al. The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities. J Biochem Mol Toxicol. 2019;33(6):e22313.
Taslimi, P., Kandemir, F. M., Demir, Y., İleritürk, M., Temel, Y., Caglayan, C., & Gulçin, İ. (2019). The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities. Journal of Biochemical and Molecular Toxicology, 33(6), e22313. https://doi.org/10.1002/jbt.22313
Taslimi P, et al. The Antidiabetic and Anticholinergic Effects of Chrysin On Cyclophosphamide-induced Multiple Organ Toxicity in Rats: Pharmacological Evaluation of some Metabolic Enzyme Activities. J Biochem Mol Toxicol. 2019;33(6):e22313. PubMed PMID: 30801880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities. AU - Taslimi,Parham, AU - Kandemir,Fatih Mehmet, AU - Demir,Yeliz, AU - İleritürk,Mustafa, AU - Temel,Yusuf, AU - Caglayan,Cuneyt, AU - Gulçin,İlhami, Y1 - 2019/02/22/ PY - 2018/09/19/received PY - 2019/01/08/revised PY - 2019/01/24/accepted PY - 2019/2/26/pubmed PY - 2020/8/6/medline PY - 2019/2/26/entrez KW - chrysin KW - cyclophosphamide KW - enzyme activities KW - in vivo KW - metabolic enzymes KW - rats SP - e22313 EP - e22313 JF - Journal of biochemical and molecular toxicology JO - J. Biochem. Mol. Toxicol. VL - 33 IS - 6 N2 - Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used. The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity. SN - 1099-0461 UR - https://www.unboundmedicine.com/medline/citation/30801880/The_antidiabetic_and_anticholinergic_effects_of_chrysin_on_cyclophosphamide_induced_multiple_organ_toxicity_in_rats:_Pharmacological_evaluation_of_some_metabolic_enzyme_activities_ L2 - https://doi.org/10.1002/jbt.22313 DB - PRIME DP - Unbound Medicine ER -