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Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion.
Acta Ophthalmol. 2019 May; 97(3):273-278.AO

Abstract

PURPOSE

To investigate the semophorin 3A (SEMA3A) level in aqueous humor of patients with retinal vein occlusion (RVO) and explore the correlation of SEMA3A with macular oedema and ganglion cell degeneration in RVO.

METHODS

This comparative study prospectively included 41 consecutive patients (41 eyes) with RVO who had intravitreal anti-VEGF injections from March 2014 to March 2015 for cystoid macular oedema (CME) or neovascular glaucoma (NVG). The patients were divided into three groups according to the fluorescein angiograghy (FFA): central retinal vein occlusion (CRVO) group (n = 15), branch retinal vein occlusion (BRVO) group (n = 15) and NVG group (secondary to CRVO, n = 11). The patients who had undergone cataract surgery (n = 16) during the same period served as controls. The SEMA3A concentration in aqueous humor collected before the initial anti-VEGF injection was determined by enzyme-linked immunosorbent assay (ELISA). Central retinal thickness (CRT), cube volume (CV) and ganglion cell-inner plexiform layer (GC-IPL) thickness was analysed by spectral-domain optical coherence tomography (SD-OCT).

RESULTS

Semaphorin 3A level in CRVO group (1.52 ± 1.23 ng/ml) and NVG group (1.67 ± 0.98 ng/ml) were significantly higher than the control group (0.66 ± 0.58 ng/ml; both p < 0.05). Moreover, SEMA3A level in CRVO group was higher than BRVO group (1.52 ± 1.23 ng/ml versus 0.53 ± 0.37 ng/ml; p < 0.05). SEMA3A level was positively correlated with CRT and CV in both BRVO group (CRTr = 0.6535, p = 0.0082; CVr = 0.5190, p = 0.0474) and CRVO group (CRTr = 0.6270, p = 0.0124; CVr = 0.6898, p = 0.0044). In RVO patients, the GC-IPL thickness of affected eyes were significantly reduced compared with the normal follow eyes (CRVOt = 4.55, p = 0.006; BRVOt = 4.54, p = 0.004). Meanwhile, negative correlation of SEMA3A level with GC-IPL thickness was found in both BRVO group (r = -0.5906, p = 0.0205) and CRVO group (r = -0.6100, p = 0.0157).

CONCLUSION

Semaphorin 3A level is increased in aqueous humor of RVO patients. Positive correlation of CRT as well as negative correlation of GC-IPL thickness with SEMA3A may suggest a pathological role of SEMA3A in macular oedema and ganglion cell degeneration during RVO.

Authors+Show Affiliations

Department of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Department of Ophthalmology, Xi'an Third Hospital, Xi'an, China.Department of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.Department of Clinical Laboratory, Xi'an Third Hospital, Xi'an, China.No affiliation info availableDepartment of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.Department of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30803163

Citation

Guo, Shengxiang, et al. "Aqueous Semaphorin 3A Level Correlates With Retinal Macular Oedema and Ganglion Cell Degeneration in Patients With Retinal Vein Occlusion." Acta Ophthalmologica, vol. 97, no. 3, 2019, pp. 273-278.
Guo S, Ren J, Li Z, et al. Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion. Acta Ophthalmol. 2019;97(3):273-278.
Guo, S., Ren, J., Li, Z., Fan, X., Qin, L., & Li, J. (2019). Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion. Acta Ophthalmologica, 97(3), 273-278. https://doi.org/10.1111/aos.14079
Guo S, et al. Aqueous Semaphorin 3A Level Correlates With Retinal Macular Oedema and Ganglion Cell Degeneration in Patients With Retinal Vein Occlusion. Acta Ophthalmol. 2019;97(3):273-278. PubMed PMID: 30803163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion. AU - Guo,Shengxiang, AU - Ren,Jiawei, AU - Li,Zhengli, AU - Fan,Xiaojuan, AU - Qin,Li, AU - Li,Jingming, Y1 - 2019/02/25/ PY - 2018/09/30/received PY - 2019/02/02/accepted PY - 2019/2/26/pubmed PY - 2019/4/25/medline PY - 2019/2/26/entrez KW - central retinal thickness KW - cube volume KW - ganglion cell-inner plexiform layer thickness KW - retinal vein occlusion KW - semaphorin 3A SP - 273 EP - 278 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 97 IS - 3 N2 - PURPOSE: To investigate the semophorin 3A (SEMA3A) level in aqueous humor of patients with retinal vein occlusion (RVO) and explore the correlation of SEMA3A with macular oedema and ganglion cell degeneration in RVO. METHODS: This comparative study prospectively included 41 consecutive patients (41 eyes) with RVO who had intravitreal anti-VEGF injections from March 2014 to March 2015 for cystoid macular oedema (CME) or neovascular glaucoma (NVG). The patients were divided into three groups according to the fluorescein angiograghy (FFA): central retinal vein occlusion (CRVO) group (n = 15), branch retinal vein occlusion (BRVO) group (n = 15) and NVG group (secondary to CRVO, n = 11). The patients who had undergone cataract surgery (n = 16) during the same period served as controls. The SEMA3A concentration in aqueous humor collected before the initial anti-VEGF injection was determined by enzyme-linked immunosorbent assay (ELISA). Central retinal thickness (CRT), cube volume (CV) and ganglion cell-inner plexiform layer (GC-IPL) thickness was analysed by spectral-domain optical coherence tomography (SD-OCT). RESULTS: Semaphorin 3A level in CRVO group (1.52 ± 1.23 ng/ml) and NVG group (1.67 ± 0.98 ng/ml) were significantly higher than the control group (0.66 ± 0.58 ng/ml; both p < 0.05). Moreover, SEMA3A level in CRVO group was higher than BRVO group (1.52 ± 1.23 ng/ml versus 0.53 ± 0.37 ng/ml; p < 0.05). SEMA3A level was positively correlated with CRT and CV in both BRVO group (CRTr = 0.6535, p = 0.0082; CVr = 0.5190, p = 0.0474) and CRVO group (CRTr = 0.6270, p = 0.0124; CVr = 0.6898, p = 0.0044). In RVO patients, the GC-IPL thickness of affected eyes were significantly reduced compared with the normal follow eyes (CRVOt = 4.55, p = 0.006; BRVOt = 4.54, p = 0.004). Meanwhile, negative correlation of SEMA3A level with GC-IPL thickness was found in both BRVO group (r = -0.5906, p = 0.0205) and CRVO group (r = -0.6100, p = 0.0157). CONCLUSION: Semaphorin 3A level is increased in aqueous humor of RVO patients. Positive correlation of CRT as well as negative correlation of GC-IPL thickness with SEMA3A may suggest a pathological role of SEMA3A in macular oedema and ganglion cell degeneration during RVO. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/30803163/Aqueous_semaphorin_3A_level_correlates_with_retinal_macular_oedema_and_ganglion_cell_degeneration_in_patients_with_retinal_vein_occlusion_ L2 - https://doi.org/10.1111/aos.14079 DB - PRIME DP - Unbound Medicine ER -