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Primary leptomeningeal gliomatosis in a domestic shorthaired cat.
J Vet Diagn Invest 2019; 31(1):94-97JV

Abstract

A 15-y-old neutered male domestic shorthaired cat was presented with a 16-d history of hindlimb paralysis in conjunction with 1-wk duration of inappetence and lethargy. Given intractable clinical signs, development of seizures, and poor prognosis, euthanasia was elected. Gross examination revealed mild, chronic, multifocal intervertebral disk disease; however, no gross abnormalities were noted in the spinal cord. Histologic examination of the cervical, thoracic, and lumbar spinal cord and the myelencephalon revealed diffuse and variable expansion of the meninges by sheets of neoplastic round-to-polygonal cells. The cells formed sheets and clusters, supported by a variably eosinophilic, fibrillar-to-basophilic, homogeneous matrix, and contained a small amount of eosinophilic cytoplasm. The nuclei were round with finely stippled to hyperchromatic chromatin and 1-2 small nucleoli. Mild white matter degeneration was present in the dorsal and ventral funiculi multifocally throughout the spinal cord, but was most severe in the ventral lumbar sections. Immunohistochemistry revealed strong intranuclear immunoreactivity for Olig2, and intracytoplasmic immunoreactivity for glial fibrillary acidic protein, MAP2, and vimentin in the neoplastic glial cells. To our knowledge, primary leptomeningeal gliomatosis has not been reported previously in a cat.

Authors+Show Affiliations

Antech Diagnostics, College Station, TX (Zoll). Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY (Miller). Canada West Veterinary Specialists, ECC, Vancouver, BC, Canada (Bandt). Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL (Abbott).Antech Diagnostics, College Station, TX (Zoll). Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY (Miller). Canada West Veterinary Specialists, ECC, Vancouver, BC, Canada (Bandt). Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL (Abbott).Antech Diagnostics, College Station, TX (Zoll). Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY (Miller). Canada West Veterinary Specialists, ECC, Vancouver, BC, Canada (Bandt). Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL (Abbott).Antech Diagnostics, College Station, TX (Zoll). Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY (Miller). Canada West Veterinary Specialists, ECC, Vancouver, BC, Canada (Bandt). Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL (Abbott).

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30803413

Citation

Zoll, Whitney M., et al. "Primary Leptomeningeal Gliomatosis in a Domestic Shorthaired Cat." Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, vol. 31, no. 1, 2019, pp. 94-97.
Zoll WM, Miller AD, Bandt C, et al. Primary leptomeningeal gliomatosis in a domestic shorthaired cat. J Vet Diagn Invest. 2019;31(1):94-97.
Zoll, W. M., Miller, A. D., Bandt, C., & Abbott, J. R. (2019). Primary leptomeningeal gliomatosis in a domestic shorthaired cat. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 31(1), pp. 94-97. doi:10.1177/1040638718822683.
Zoll WM, et al. Primary Leptomeningeal Gliomatosis in a Domestic Shorthaired Cat. J Vet Diagn Invest. 2019;31(1):94-97. PubMed PMID: 30803413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary leptomeningeal gliomatosis in a domestic shorthaired cat. AU - Zoll,Whitney M, AU - Miller,Andrew D, AU - Bandt,Carston, AU - Abbott,Jeffrey R, PY - 2020/01/15/pmc-release PY - 2019/2/27/entrez PY - 2019/2/26/pubmed PY - 2019/4/12/medline KW - Feline KW - MAP2 KW - Olig2 KW - gliomatosis SP - 94 EP - 97 JF - Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc JO - J. Vet. Diagn. Invest. VL - 31 IS - 1 N2 - A 15-y-old neutered male domestic shorthaired cat was presented with a 16-d history of hindlimb paralysis in conjunction with 1-wk duration of inappetence and lethargy. Given intractable clinical signs, development of seizures, and poor prognosis, euthanasia was elected. Gross examination revealed mild, chronic, multifocal intervertebral disk disease; however, no gross abnormalities were noted in the spinal cord. Histologic examination of the cervical, thoracic, and lumbar spinal cord and the myelencephalon revealed diffuse and variable expansion of the meninges by sheets of neoplastic round-to-polygonal cells. The cells formed sheets and clusters, supported by a variably eosinophilic, fibrillar-to-basophilic, homogeneous matrix, and contained a small amount of eosinophilic cytoplasm. The nuclei were round with finely stippled to hyperchromatic chromatin and 1-2 small nucleoli. Mild white matter degeneration was present in the dorsal and ventral funiculi multifocally throughout the spinal cord, but was most severe in the ventral lumbar sections. Immunohistochemistry revealed strong intranuclear immunoreactivity for Olig2, and intracytoplasmic immunoreactivity for glial fibrillary acidic protein, MAP2, and vimentin in the neoplastic glial cells. To our knowledge, primary leptomeningeal gliomatosis has not been reported previously in a cat. SN - 1943-4936 UR - https://www.unboundmedicine.com/medline/citation/30803413/Primary_leptomeningeal_gliomatosis_in_a_domestic_shorthaired_cat L2 - http://journals.sagepub.com/doi/full/10.1177/1040638718822683?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -