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Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets.
Front Microbiol. 2019; 10:90.FM

Abstract

Lactobacillus plantarum is a widespread bacterial species and is commonly used as a probiotic. L. plantarum PFM105 was isolated from the rectum of a healthy sow. Here we found that L. plantarum PFM105 showed probiotic effect on weaning piglets in which intestinal inflammation and unbalanced gut microbiota happened frequently. L. plantarum PFM105 was identified to improve the growth of weaning piglet and promote the development of small intestinal villi. Antibiotics are often used in weaning piglet to prevent intestinal infection and promote the growth of animal. We found that weaning piglets feeding with L. plantarum PFM105 showed similar growth promotion but decreased diarrhea incidence compared with those feeding with antibiotics. High-throughput sequencing was used to analyze the gut microbiota in weaning piglets treated with L. plantarum PFM105 or antibiotics. The relative abundance of beneficial microbes Prevotellaceae and Bifidobacteriaceae were increased in colon of weaning piglet feeding L. plantarum PFM105, while antibiotics increased the relative abundance of bacteria associated with pathogenicity, such as Spirochaeta and Campylobacteraceae. L. plantarum PFM 105 increased indicators of intestinal health including serum levels of IgM, IL-10, and TGF-β, and colonic levels of SCFAs. We found strong correlations between the alterations in gut microbiota composition caused by feeding antibiotics and probiotics and the measured growth and health parameters in weaning piglets. The addition of L. plantarum PFM105 could significantly increase the relative abundance of metabolic genes which may important to intestinal microbiota maturation. Altogether, we demonstrated here that L. plantarum PFM 105 could promote intestinal development through modulation of gut microbiota in weaning piglets.

Authors+Show Affiliations

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. School of Life Science, University of Chinese Academy of Sciences, Beijing, China.State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. School of Life Science, University of Chinese Academy of Sciences, Beijing, China.State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. School of Life Science, University of Chinese Academy of Sciences, Beijing, China.State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.LongDa Foodstuff Group Co., Ltd, Laiyang, China.LongDa Foodstuff Group Co., Ltd, Laiyang, China.State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. School of Life Science, University of Chinese Academy of Sciences, Beijing, China.State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. School of Life Science, University of Chinese Academy of Sciences, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30804899

Citation

Wang, Tianwei, et al. "Lactobacillus Plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets." Frontiers in Microbiology, vol. 10, 2019, p. 90.
Wang T, Teng K, Liu Y, et al. Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets. Front Microbiol. 2019;10:90.
Wang, T., Teng, K., Liu, Y., Shi, W., Zhang, J., Dong, E., Zhang, X., Tao, Y., & Zhong, J. (2019). Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets. Frontiers in Microbiology, 10, 90. https://doi.org/10.3389/fmicb.2019.00090
Wang T, et al. Lactobacillus Plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets. Front Microbiol. 2019;10:90. PubMed PMID: 30804899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets. AU - Wang,Tianwei, AU - Teng,Kunling, AU - Liu,Yayong, AU - Shi,Weixiong, AU - Zhang,Jie, AU - Dong,Enqiu, AU - Zhang,Xin, AU - Tao,Yong, AU - Zhong,Jin, Y1 - 2019/02/05/ PY - 2018/11/16/received PY - 2019/01/16/accepted PY - 2019/2/27/entrez PY - 2019/2/26/pubmed PY - 2019/2/26/medline KW - Lactobacillus plantarum KW - antibiotics KW - intestinal development KW - microbiota KW - weaning piglets SP - 90 EP - 90 JF - Frontiers in microbiology JO - Front Microbiol VL - 10 N2 - Lactobacillus plantarum is a widespread bacterial species and is commonly used as a probiotic. L. plantarum PFM105 was isolated from the rectum of a healthy sow. Here we found that L. plantarum PFM105 showed probiotic effect on weaning piglets in which intestinal inflammation and unbalanced gut microbiota happened frequently. L. plantarum PFM105 was identified to improve the growth of weaning piglet and promote the development of small intestinal villi. Antibiotics are often used in weaning piglet to prevent intestinal infection and promote the growth of animal. We found that weaning piglets feeding with L. plantarum PFM105 showed similar growth promotion but decreased diarrhea incidence compared with those feeding with antibiotics. High-throughput sequencing was used to analyze the gut microbiota in weaning piglets treated with L. plantarum PFM105 or antibiotics. The relative abundance of beneficial microbes Prevotellaceae and Bifidobacteriaceae were increased in colon of weaning piglet feeding L. plantarum PFM105, while antibiotics increased the relative abundance of bacteria associated with pathogenicity, such as Spirochaeta and Campylobacteraceae. L. plantarum PFM 105 increased indicators of intestinal health including serum levels of IgM, IL-10, and TGF-β, and colonic levels of SCFAs. We found strong correlations between the alterations in gut microbiota composition caused by feeding antibiotics and probiotics and the measured growth and health parameters in weaning piglets. The addition of L. plantarum PFM105 could significantly increase the relative abundance of metabolic genes which may important to intestinal microbiota maturation. Altogether, we demonstrated here that L. plantarum PFM 105 could promote intestinal development through modulation of gut microbiota in weaning piglets. SN - 1664-302X UR - https://www.unboundmedicine.com/medline/citation/30804899/Lactobacillus_plantarum_PFM_105_Promotes_Intestinal_Development_Through_Modulation_of_Gut_Microbiota_in_Weaning_Piglets L2 - https://doi.org/10.3389/fmicb.2019.00090 DB - PRIME DP - Unbound Medicine ER -
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