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Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis.
Psychiatry Res. 2019 04; 274:228-234.PR

Abstract

Current research suggests conflicting evidence surrounding the association between serum magnesium levels and the diagnosis of attention deficit hyperactivity disorder (ADHD). This systematic review and meta-analysis aims to explore, summarize and quantify the published literature addressing this topic. We conducted an exhaustive literature search on Scopus and PubMed for all the relevant observational studies published up to August 2018. A meta-analysis using a random-effects model was used to summarize the overall association between serum magnesium level and ADHD from the available data. We identified seven studies which reported the mean and standard deviation (SD) of magnesium concentration in both ADHD and control groups. The random-effects meta-analysis showed that subjects with ADHD had 0.105 mmol/l (95% CI: -0.188, -0.022; P < 0.013) lower serum magnesium levels compared with to their healthy controls. Moreover, we observed striking and statistically significant heterogeneity among the included studies (I2 = 96.2%, P = 0.0103). The evidence from this meta-analysis supports the theory that an inverse relationship between serum magnesium deficiency and ADHD exists. High heterogeneity amongst the included studies suggests that there is a residual need for observational and community-based studies to further investigate this issue.

Authors+Show Affiliations

Department of Psychiatry, Ziaeian Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran.Department of Psychiatry, Ziaeian Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran.Department of Microbiology, Asadabad School of Medical Sciences, Asadabad, Iran.School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: hamedkord39@yahoo.com.Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.St.George's Hospital, London, United Kingdom.Department of Geriatric Medicine, Ziaeian Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran. Electronic address: r_hashemi@tums.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30807974

Citation

Effatpanah, Mohammad, et al. "Magnesium Status and Attention Deficit Hyperactivity Disorder (ADHD): a Meta-analysis." Psychiatry Research, vol. 274, 2019, pp. 228-234.
Effatpanah M, Rezaei M, Effatpanah H, et al. Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis. Psychiatry Res. 2019;274:228-234.
Effatpanah, M., Rezaei, M., Effatpanah, H., Effatpanah, Z., Varkaneh, H. K., Mousavi, S. M., Fatahi, S., Rinaldi, G., & Hashemi, R. (2019). Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis. Psychiatry Research, 274, 228-234. https://doi.org/10.1016/j.psychres.2019.02.043
Effatpanah M, et al. Magnesium Status and Attention Deficit Hyperactivity Disorder (ADHD): a Meta-analysis. Psychiatry Res. 2019;274:228-234. PubMed PMID: 30807974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis. AU - Effatpanah,Mohammad, AU - Rezaei,Mahdi, AU - Effatpanah,Hosein, AU - Effatpanah,Zeynab, AU - Varkaneh,Hamed Kord, AU - Mousavi,Seyed Mohammad, AU - Fatahi,Somaye, AU - Rinaldi,Giulia, AU - Hashemi,Rezvan, Y1 - 2019/02/19/ PY - 2018/10/02/received PY - 2019/02/18/revised PY - 2019/02/18/accepted PY - 2019/2/27/pubmed PY - 2019/6/14/medline PY - 2019/2/27/entrez KW - ADHD KW - Adolescents KW - Children KW - Magnesium KW - Meta-analysis SP - 228 EP - 234 JF - Psychiatry research JO - Psychiatry Res VL - 274 N2 - Current research suggests conflicting evidence surrounding the association between serum magnesium levels and the diagnosis of attention deficit hyperactivity disorder (ADHD). This systematic review and meta-analysis aims to explore, summarize and quantify the published literature addressing this topic. We conducted an exhaustive literature search on Scopus and PubMed for all the relevant observational studies published up to August 2018. A meta-analysis using a random-effects model was used to summarize the overall association between serum magnesium level and ADHD from the available data. We identified seven studies which reported the mean and standard deviation (SD) of magnesium concentration in both ADHD and control groups. The random-effects meta-analysis showed that subjects with ADHD had 0.105 mmol/l (95% CI: -0.188, -0.022; P < 0.013) lower serum magnesium levels compared with to their healthy controls. Moreover, we observed striking and statistically significant heterogeneity among the included studies (I2 = 96.2%, P = 0.0103). The evidence from this meta-analysis supports the theory that an inverse relationship between serum magnesium deficiency and ADHD exists. High heterogeneity amongst the included studies suggests that there is a residual need for observational and community-based studies to further investigate this issue. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/30807974/Magnesium_status_and_attention_deficit_hyperactivity_disorder__ADHD_:_A_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(18)31845-6 DB - PRIME DP - Unbound Medicine ER -