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Impact of the Gastro-Intestinal Bacterial Microbiome on Helicobacter-Associated Diseases.
Healthcare (Basel). 2019 Feb 22; 7(1)H

Abstract

Helicobacter pylori is a bacterium that selectively infects the gastric epithelium of half of the world population. The microbiome, community of microorganisms gained major interest over the last years, due to its modification associated to health and disease states. Even if most of these descriptions have focused on chronic disorders, this review describes the impact of the intestinal bacterial microbiome on host response to Helicobacter associated diseases. Microbiome has a direct impact on host cells, major barrier of the gastro-intestinal tract, but also an indirect impact on immune system stimulation, by enhancing or decreasing non-specific or adaptive response. In microbial infections, especially in precancerous lesions induced by Helicobacter pylori infection, these modifications could lead to different outcome. Associated to data focusing on the microbiome, transcriptomic analyses of the eukaryote response would lead to a complete understanding of these complex interactions and will allow to characterize innovative biomarkers and personalized therapies.

Authors+Show Affiliations

Bacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, France. maxime.pichon@chu-poitiers.fr. Laboratoire Inflammation, Tissus Épithéliaux et Cytokines, EA 4331, Faculté de Médecine et de Pharmacie, University of Poitiers, 86022 Poitiers, France. maxime.pichon@chu-poitiers.fr.Bacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, France. christophe.burucoa@chu-poitiers.fr. Laboratoire Inflammation, Tissus Épithéliaux et Cytokines, EA 4331, Faculté de Médecine et de Pharmacie, University of Poitiers, 86022 Poitiers, France. christophe.burucoa@chu-poitiers.fr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30813360

Citation

Pichon, Maxime, and Christophe Burucoa. "Impact of the Gastro-Intestinal Bacterial Microbiome On Helicobacter-Associated Diseases." Healthcare (Basel, Switzerland), vol. 7, no. 1, 2019.
Pichon M, Burucoa C. Impact of the Gastro-Intestinal Bacterial Microbiome on Helicobacter-Associated Diseases. Healthcare (Basel, Switzerland). 2019;7(1).
Pichon, M., & Burucoa, C. (2019). Impact of the Gastro-Intestinal Bacterial Microbiome on Helicobacter-Associated Diseases. Healthcare (Basel, Switzerland), 7(1). https://doi.org/10.3390/healthcare7010034
Pichon M, Burucoa C. Impact of the Gastro-Intestinal Bacterial Microbiome On Helicobacter-Associated Diseases. Healthcare (Basel, Switzerland). 2019 Feb 22;7(1) PubMed PMID: 30813360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of the Gastro-Intestinal Bacterial Microbiome on Helicobacter-Associated Diseases. AU - Pichon,Maxime, AU - Burucoa,Christophe, Y1 - 2019/02/22/ PY - 2019/01/31/received PY - 2019/02/18/revised PY - 2019/02/20/accepted PY - 2019/3/1/entrez PY - 2019/3/1/pubmed PY - 2019/3/1/medline KW - 16S KW - Helicobacter pylori KW - NGS KW - bacterial infections KW - gastrointestinal cancer KW - gastrointestinal tract KW - stool microbiome KW - whole genome sequencing JF - Healthcare (Basel, Switzerland) VL - 7 IS - 1 N2 - Helicobacter pylori is a bacterium that selectively infects the gastric epithelium of half of the world population. The microbiome, community of microorganisms gained major interest over the last years, due to its modification associated to health and disease states. Even if most of these descriptions have focused on chronic disorders, this review describes the impact of the intestinal bacterial microbiome on host response to Helicobacter associated diseases. Microbiome has a direct impact on host cells, major barrier of the gastro-intestinal tract, but also an indirect impact on immune system stimulation, by enhancing or decreasing non-specific or adaptive response. In microbial infections, especially in precancerous lesions induced by Helicobacter pylori infection, these modifications could lead to different outcome. Associated to data focusing on the microbiome, transcriptomic analyses of the eukaryote response would lead to a complete understanding of these complex interactions and will allow to characterize innovative biomarkers and personalized therapies. SN - 2227-9032 UR - https://www.unboundmedicine.com/medline/citation/30813360/Impact_of_the_Gastro_Intestinal_Bacterial_Microbiome_on_Helicobacter_Associated_Diseases_ L2 - https://www.mdpi.com/resolver?pii=healthcare7010034 DB - PRIME DP - Unbound Medicine ER -
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