Tags

Type your tag names separated by a space and hit enter

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload.
Sci Rep 2019; 9(1):2956SR

Abstract

Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. However, recent evidence suggests that AVR outcome can be improved if performed earlier. After AVR, the process of left ventricle (LV) reverse remodelling (RR) is variable and frequently incomplete. In this study, we aimed at detecting mechanism underlying the process of LV RR regarding myocardial structural, functional and molecular changes before the onset of HF symptoms. Wistar-Han rats were subjected to 7-weeks of ascending aortic-banding followed by a 2-week period of debanding to resemble AS-induced LV remodelling and the early events of AVR-induced RR, respectively. This resulted in 3 groups: Sham (n = 10), Banding (Ba, n = 15) and Debanding (Deb, n = 10). Concentric hypertrophy and diastolic dysfunction (DD) were patent in the Ba group. Aortic-debanding induced RR, which promoted LV functional recovery, while cardiac structure did not normalise. Cardiac parameters of RV dysfunction, assessed by echocardiography and at the cardiomyocyte level prevailed altered after debanding. After debanding, these alterations were accompanied by persistent changes in pathways associated to myocardial hypertrophy, fibrosis and LV inflammation. Aortic banding induced pulmonary arterial wall thickness to increase and correlates negatively with effort intolerance and positively with E/e' and left atrial area. We described dysregulated pathways in LV and RV remodelling and RR after AVR. Importantly we showed important RV-side effects of aortic constriction, highlighting the impact that LV-reverse remodelling has on both ventricles.

Authors+Show Affiliations

Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Systems Physiology, Ruhr University, Bochum, Germany.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra and CIBERCV, Pamplona, Spain. Department of Cardiology and Cardiac Surgery and Department of Nephrology, University of Navarra Clinic, Pamplona, Spain.Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra and CIBERCV, Pamplona, Spain. Department of Cardiology and Cardiac Surgery and Department of Nephrology, University of Navarra Clinic, Pamplona, Spain.Institute of Physiology II, University of Muenster, Muenster, Germany.Department of Surgery and Physiology, University of Porto, Porto, Portugal.Department of Surgery and Physiology, University of Porto, Porto, Portugal. ipires@med.up.pt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30814653

Citation

Miranda-Silva, Daniela, et al. "Characterization of Biventricular Alterations in Myocardial (reverse) Remodelling in Aortic Banding-induced Chronic Pressure Overload." Scientific Reports, vol. 9, no. 1, 2019, p. 2956.
Miranda-Silva D, Gonçalves-Rodrigues P, Almeida-Coelho J, et al. Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload. Sci Rep. 2019;9(1):2956.
Miranda-Silva, D., Gonçalves-Rodrigues, P., Almeida-Coelho, J., Hamdani, N., Lima, T., Conceição, G., ... Falcão-Pires, I. (2019). Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload. Scientific Reports, 9(1), p. 2956. doi:10.1038/s41598-019-39581-9.
Miranda-Silva D, et al. Characterization of Biventricular Alterations in Myocardial (reverse) Remodelling in Aortic Banding-induced Chronic Pressure Overload. Sci Rep. 2019 Feb 27;9(1):2956. PubMed PMID: 30814653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload. AU - Miranda-Silva,Daniela, AU - Gonçalves-Rodrigues,Patrícia, AU - Almeida-Coelho,João, AU - Hamdani,Nazha, AU - Lima,Tânia, AU - Conceição,Glória, AU - Sousa-Mendes,Cláudia, AU - Cláudia-Moura,, AU - González,Arantxa, AU - Díez,Javier, AU - Linke,Wolfgang A, AU - Leite-Moreira,Adelino, AU - Falcão-Pires,Inês, Y1 - 2019/02/27/ PY - 2018/10/09/received PY - 2019/01/18/accepted PY - 2019/3/1/entrez PY - 2019/3/1/pubmed PY - 2019/3/1/medline SP - 2956 EP - 2956 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. However, recent evidence suggests that AVR outcome can be improved if performed earlier. After AVR, the process of left ventricle (LV) reverse remodelling (RR) is variable and frequently incomplete. In this study, we aimed at detecting mechanism underlying the process of LV RR regarding myocardial structural, functional and molecular changes before the onset of HF symptoms. Wistar-Han rats were subjected to 7-weeks of ascending aortic-banding followed by a 2-week period of debanding to resemble AS-induced LV remodelling and the early events of AVR-induced RR, respectively. This resulted in 3 groups: Sham (n = 10), Banding (Ba, n = 15) and Debanding (Deb, n = 10). Concentric hypertrophy and diastolic dysfunction (DD) were patent in the Ba group. Aortic-debanding induced RR, which promoted LV functional recovery, while cardiac structure did not normalise. Cardiac parameters of RV dysfunction, assessed by echocardiography and at the cardiomyocyte level prevailed altered after debanding. After debanding, these alterations were accompanied by persistent changes in pathways associated to myocardial hypertrophy, fibrosis and LV inflammation. Aortic banding induced pulmonary arterial wall thickness to increase and correlates negatively with effort intolerance and positively with E/e' and left atrial area. We described dysregulated pathways in LV and RV remodelling and RR after AVR. Importantly we showed important RV-side effects of aortic constriction, highlighting the impact that LV-reverse remodelling has on both ventricles. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/30814653/Characterization_of_biventricular_alterations_in_myocardial_(reverse)_remodelling_in_aortic_banding-induced_chronic_pressure_overload L2 - http://dx.doi.org/10.1038/s41598-019-39581-9 DB - PRIME DP - Unbound Medicine ER -