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Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not?

Abstract

Objective

Granulomatous mastitis is a rare, benign, chronic inflammatory disease of the breast of unknown etiology. This study evaluated bacteriologic agents that might play a role in the etiology of granulomatous mastitis using a molecular method with a universal primer after isolating deoxyribonucleic acid (DNA) from pathology specimens from patients diagnosed with granulomatous mastitis.

Materials and Methods

Breast biopsy material in the pathology department obtained between July 2008 and June 2013 was analyzed. The history of the granulomatous mastitis patients was examined in detail and paraffin block sections of the biopsy material were used to determine the presence of bacteria with a universal DNA primer.

Results

This study examined 45 granulomatous mastitis patients who had been diagnosed using excisional, incisional, or core biopsies. We evaluated multiple bacterial taxa, but obtained no positive result using a nucleic-acid-based assay with a universal primer.

Conclusion

The etiology of idiopathic granulomatous mastitis remains unclear. Further studies with a large number of patients should aim to identify the causative agent.

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  • Authors+Show Affiliations

    ,

    Department of General Surgery, Okan University School of Medicine, İstanbul, Turkey. Department of General Surgery, Sakarya University Training and Research Hospital, Sakarya, Turkey.

    ,

    Department of General Surgery, Sakarya University School of Medicine, Sakarya, Turkey. Department of General Surgery, İstinye University School of Medicine, İstanbul, Turkey.

    ,

    Department of Pathology, Sakarya University Training and Research Hospital, Sakarya, Turkey.

    ,

    Department of General Surgery, Okan University School of Medicine, İstanbul, Turkey.

    ,

    Department of General Surgery, Okan University School of Medicine, İstanbul, Turkey.

    ,

    Department of General Surgery, Sakarya University Training and Research Hospital, Sakarya, Turkey.

    ,

    Department of Microbiology, Sakarya University School of Medicine, Sakarya, Turkey.

    Department of Pathology, İzmir Katip Çelebi University School of Medicine, İzmir, Turkey.

    Source

    European journal of breast health 15:1 2019 Jan pg 32-36

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    30816358

    Citation

    Kıvılcım, Taner, et al. "Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not?" European Journal of Breast Health, vol. 15, no. 1, 2019, pp. 32-36.
    Kıvılcım T, Altıntoprak F, Memiş B, et al. Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not? Eur J Breast Health. 2019;15(1):32-36.
    Kıvılcım, T., Altıntoprak, F., Memiş, B., Ferhatoğlu, M. F., Kartal, A., Dikicier, E., ... Dilek, F. H. (2019). Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not? European Journal of Breast Health, 15(1), pp. 32-36. doi:10.5152/ejbh.2018.4249.
    Kıvılcım T, et al. Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not. Eur J Breast Health. 2019;15(1):32-36. PubMed PMID: 30816358.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not? AU - Kıvılcım,Taner, AU - Altıntoprak,Fatih, AU - Memiş,Bahar, AU - Ferhatoğlu,Murat Ferhat, AU - Kartal,Abdulcabbar, AU - Dikicier,Enis, AU - Ciftçi,İhsan Hakkı, AU - Dilek,Fatma Hüsniye, Y1 - 2018/11/05/ PY - 2018/06/26/received PY - 2018/08/29/accepted PY - 2019/3/1/entrez PY - 2019/3/1/pubmed PY - 2019/3/1/medline KW - Mastitis KW - bacteria KW - etiology KW - granulomatous mastitis KW - idiopathic granulomatous mastitis SP - 32 EP - 36 JF - European journal of breast health JO - Eur J Breast Health VL - 15 IS - 1 N2 - Objective: Granulomatous mastitis is a rare, benign, chronic inflammatory disease of the breast of unknown etiology. This study evaluated bacteriologic agents that might play a role in the etiology of granulomatous mastitis using a molecular method with a universal primer after isolating deoxyribonucleic acid (DNA) from pathology specimens from patients diagnosed with granulomatous mastitis. Materials and Methods: Breast biopsy material in the pathology department obtained between July 2008 and June 2013 was analyzed. The history of the granulomatous mastitis patients was examined in detail and paraffin block sections of the biopsy material were used to determine the presence of bacteria with a universal DNA primer. Results: This study examined 45 granulomatous mastitis patients who had been diagnosed using excisional, incisional, or core biopsies. We evaluated multiple bacterial taxa, but obtained no positive result using a nucleic-acid-based assay with a universal primer. Conclusion: The etiology of idiopathic granulomatous mastitis remains unclear. Further studies with a large number of patients should aim to identify the causative agent. SN - 2587-0831 UR - https://www.unboundmedicine.com/medline/citation/30816358/Role_of_Bacteriological_Agents_in_Idiopathic_Granulomatous_Mastitis:_Real_or_Not L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30816358/ DB - PRIME DP - Unbound Medicine ER -