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The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study.
Pharmacol Rep 2019; 71(2):243-247PR

Abstract

BACKGROUND

Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto's thyroiditis.

METHODS

The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel's thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study.

RESULTS

At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D.

CONCLUSIONS

Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto's thyroiditis.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30818086

Citation

Krysiak, Robert, et al. "The Effect of Vitamin D and Selenomethionine On Thyroid Antibody Titers, Hypothalamic-pituitary-thyroid Axis Activity and Thyroid Function Tests in Men With Hashimoto's Thyroiditis: a Pilot Study." Pharmacological Reports : PR, vol. 71, no. 2, 2019, pp. 243-247.
Krysiak R, Szkróbka W, Okopień B. The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. Pharmacol Rep. 2019;71(2):243-247.
Krysiak, R., Szkróbka, W., & Okopień, B. (2019). The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. Pharmacological Reports : PR, 71(2), pp. 243-247. doi:10.1016/j.pharep.2018.10.012.
Krysiak R, Szkróbka W, Okopień B. The Effect of Vitamin D and Selenomethionine On Thyroid Antibody Titers, Hypothalamic-pituitary-thyroid Axis Activity and Thyroid Function Tests in Men With Hashimoto's Thyroiditis: a Pilot Study. Pharmacol Rep. 2019;71(2):243-247. PubMed PMID: 30818086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2018/10/24/ PY - 2018/06/04/received PY - 2018/09/22/revised PY - 2018/10/23/accepted PY - 2019/3/1/pubmed PY - 2019/6/18/medline PY - 2019/3/1/entrez KW - Selenium KW - Thyroid autoimmunity KW - Thyroid function tests KW - Vitamin D SP - 243 EP - 247 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 71 IS - 2 N2 - BACKGROUND: Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto's thyroiditis. METHODS: The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel's thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study. RESULTS: At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D. CONCLUSIONS: Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto's thyroiditis. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/30818086/The_effect_of_vitamin_D_and_selenomethionine_on_thyroid_antibody_titers_hypothalamic_pituitary_thyroid_axis_activity_and_thyroid_function_tests_in_men_with_Hashimoto's_thyroiditis:_A_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(18)30265-2 DB - PRIME DP - Unbound Medicine ER -