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The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study.

Abstract

BACKGROUND

Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto's thyroiditis.

METHODS

The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel's thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study.

RESULTS

At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D.

CONCLUSIONS

Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto's thyroiditis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.

    ,

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

    Source

    Pharmacological reports : PR 71:2 2019 Apr pg 243-247

    MeSH

    Adult
    Autoantibodies
    Autoantigens
    Autoimmunity
    Dietary Supplements
    Hashimoto Disease
    Humans
    Hypothalamo-Hypophyseal System
    Iodide Peroxidase
    Iron-Binding Proteins
    Male
    Pilot Projects
    Pituitary Gland
    Selenomethionine
    Thyroid Function Tests
    Thyroid Hormones
    Thyrotropin
    Vitamin D

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    30818086

    Citation

    Krysiak, Robert, et al. "The Effect of Vitamin D and Selenomethionine On Thyroid Antibody Titers, Hypothalamic-pituitary-thyroid Axis Activity and Thyroid Function Tests in Men With Hashimoto's Thyroiditis: a Pilot Study." Pharmacological Reports : PR, vol. 71, no. 2, 2019, pp. 243-247.
    Krysiak R, Szkróbka W, Okopień B. The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. Pharmacol Rep. 2019;71(2):243-247.
    Krysiak, R., Szkróbka, W., & Okopień, B. (2019). The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. Pharmacological Reports : PR, 71(2), pp. 243-247. doi:10.1016/j.pharep.2018.10.012.
    Krysiak R, Szkróbka W, Okopień B. The Effect of Vitamin D and Selenomethionine On Thyroid Antibody Titers, Hypothalamic-pituitary-thyroid Axis Activity and Thyroid Function Tests in Men With Hashimoto's Thyroiditis: a Pilot Study. Pharmacol Rep. 2019;71(2):243-247. PubMed PMID: 30818086.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2018/10/24/ PY - 2018/06/04/received PY - 2018/09/22/revised PY - 2018/10/23/accepted PY - 2019/3/1/pubmed PY - 2019/6/18/medline PY - 2019/3/1/entrez KW - Selenium KW - Thyroid autoimmunity KW - Thyroid function tests KW - Vitamin D SP - 243 EP - 247 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 71 IS - 2 N2 - BACKGROUND: Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto's thyroiditis. METHODS: The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel's thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study. RESULTS: At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D. CONCLUSIONS: Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto's thyroiditis. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/30818086/The_effect_of_vitamin_D_and_selenomethionine_on_thyroid_antibody_titers_hypothalamic_pituitary_thyroid_axis_activity_and_thyroid_function_tests_in_men_with_Hashimoto's_thyroiditis:_A_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(18)30265-2 DB - PRIME DP - Unbound Medicine ER -