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[Clinical significance of CTP combined with ABIC score in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure].
Zhonghua Gan Zang Bing Za Zhi. 2019 Feb 20; 27(2):118-122.ZG

Abstract

Objective:

To investigate the risk factors affecting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), and establish a new scoring model to predict the short-term prognosis of patients.

Methods:

This study enrolled 222 patients with HBV-ACLF. According to their clinical outcomes during hospitalization and 90 days after discharge, they were divided into survival and death group. Clinical data were collected to calculate the Child-Turcotte-Pugh (CTP), model for end-stage liver disease (MELD), albumin-bilirubin (ALBI), and age-bilirubin-international normalized ratio-creatinine (ABIC) scores for prognosis. Multivariate logistic regression analysis was used to analyze the independent risk factors affecting 90-day mortality in HBV-ACLF patients. Cox regression model was used to establish a new prediction model. Area under the receiver operating characteristic curve was used to calculate short-term prognostic value of the models. K-M survival curve was used to predict the prognosis of patients.

Results:

CTP and ABIC scores were independent risk factors for 90-day mortality in HBV-ACLF patients, and the risk of death from liver failure had increased with increase of score. Cox regression model established a new predictive model CTP-ABIC = 0.551 × CTP + 0.297 × ABIC. Area under the receiver operating characteristic curve of all three scoring models (CTP, ABIC and CTP-ABIC) were 0.878, 0.829, 0.927, respectively. CTP-ABIC score was superior to the CTP and ABIC score (P value < 0.001). Patients with CTP-ABIC score ≥9.08 had higher mortality rate than patients with CTP-ABIC score < 9.08, and the difference was statistically significant (P < 0.001).

Conclusion:

All three scoring systems can predict short-term prognosis in patients with HBV-ACLF, but the accuracy of CTP-ABIC is superior.

Authors+Show Affiliations

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30818916

Citation

Cao, D, et al. "[Clinical Significance of CTP Combined With ABIC Score in Predicting the Short-term Prognosis of Patients With Hepatitis B Virus-related Acute-on-chronic Liver Failure]." Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, vol. 27, no. 2, 2019, pp. 118-122.
Cao D, Li DJ, Wang Y, et al. [Clinical significance of CTP combined with ABIC score in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure]. Zhonghua Gan Zang Bing Za Zhi. 2019;27(2):118-122.
Cao, D., Li, D. J., Wang, Y., Zhang, Y. H., Chen, L. Y., & Wang, L. C. (2019). [Clinical significance of CTP combined with ABIC score in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, 27(2), 118-122. https://doi.org/10.3760/cma.j.issn.1007-3418.2019.02.009
Cao D, et al. [Clinical Significance of CTP Combined With ABIC Score in Predicting the Short-term Prognosis of Patients With Hepatitis B Virus-related Acute-on-chronic Liver Failure]. Zhonghua Gan Zang Bing Za Zhi. 2019 Feb 20;27(2):118-122. PubMed PMID: 30818916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical significance of CTP combined with ABIC score in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure]. AU - Cao,D, AU - Li,D J, AU - Wang,Y, AU - Zhang,Y H, AU - Chen,L Y, AU - Wang,L C, PY - 2019/3/2/entrez PY - 2019/3/2/pubmed PY - 2019/5/29/medline KW - Hepatitis B KW - Hepatitis B-related acute-on-chronic liver failure KW - Prognosis KW - Scoring model SP - 118 EP - 122 JF - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology JO - Zhonghua Gan Zang Bing Za Zhi VL - 27 IS - 2 N2 - Objective: To investigate the risk factors affecting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), and establish a new scoring model to predict the short-term prognosis of patients. Methods: This study enrolled 222 patients with HBV-ACLF. According to their clinical outcomes during hospitalization and 90 days after discharge, they were divided into survival and death group. Clinical data were collected to calculate the Child-Turcotte-Pugh (CTP), model for end-stage liver disease (MELD), albumin-bilirubin (ALBI), and age-bilirubin-international normalized ratio-creatinine (ABIC) scores for prognosis. Multivariate logistic regression analysis was used to analyze the independent risk factors affecting 90-day mortality in HBV-ACLF patients. Cox regression model was used to establish a new prediction model. Area under the receiver operating characteristic curve was used to calculate short-term prognostic value of the models. K-M survival curve was used to predict the prognosis of patients. Results: CTP and ABIC scores were independent risk factors for 90-day mortality in HBV-ACLF patients, and the risk of death from liver failure had increased with increase of score. Cox regression model established a new predictive model CTP-ABIC = 0.551 × CTP + 0.297 × ABIC. Area under the receiver operating characteristic curve of all three scoring models (CTP, ABIC and CTP-ABIC) were 0.878, 0.829, 0.927, respectively. CTP-ABIC score was superior to the CTP and ABIC score (P value < 0.001). Patients with CTP-ABIC score ≥9.08 had higher mortality rate than patients with CTP-ABIC score < 9.08, and the difference was statistically significant (P < 0.001). Conclusion: All three scoring systems can predict short-term prognosis in patients with HBV-ACLF, but the accuracy of CTP-ABIC is superior. SN - 1007-3418 UR - https://www.unboundmedicine.com/medline/citation/30818916/[Clinical_significance_of_CTP_combined_with_ABIC_score_in_predicting_the_short_term_prognosis_of_patients_with_hepatitis_B_virus_related_acute_on_chronic_liver_failure]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1007-3418&amp;year=2019&amp;vol=27&amp;issue=2&amp;fpage=118 DB - PRIME DP - Unbound Medicine ER -