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Serum folate and vitamin B12 status in young Brazilian children.
Public Health Nutr. 2019 05; 22(7):1223-1231.PH

Abstract

OBJECTIVE

To assess the nutritional status of folate and vitamin B12 with anaemia in young children.

DESIGN

A cross-sectional study was conducted at the primary health-care centres of four Brazilian cities. Folate and vitamin B12 were assessed by fluoroimmunoassay. Multilevel Poisson regression models were used to explore the association of folate and vitamin B12 status in relation to anaemia in young children.

SETTING

Brazil.ParticipantsChildren (n 460) aged 11 to 15 months.

RESULTS

The median (interquartile range) of serum folate was 39·7 (28·8-55·3) nmol/l and only four children presented with folate deficiency (<10 nmol/l). Surprisingly, 30·9 % of children presented with serum folate concentrations above the upper limit of detectable values by the commercial kit used for analysis. The frequency of vitamin B12 deficiency (<148 pmol/l) was 15 % and it was inversely associated with the highest tertile of serum folate concentrations (P<0·001). Having high serum folate concentration (≥50·1 nmol/l) and vitamin B12≥148 pmol/l was associated with lower frequency of anaemia in these children (prevalence ratio=0·53; 95% CI 0·30, 0·92).

CONCLUSIONS

High frequency of elevated serum concentration of folate was found among young Brazilian children and 15 % of them had vitamin B12 deficiency. The combination of high serum folate and normal vitamin B12 status was associated with a lower frequency of anaemia in these children. Improvements in the current strategies to promote healthy food-based complementary feeding along with prevention and control of micronutrient deficiencies are recommended to improve children's health.

Authors+Show Affiliations

1Department of Nutrition,School of Public Health,University of São Paulo,Avenida Dr Arnaldo 715,São Paulo,SP01246-904,Brazil.2Department of Global Health and Population,Harvard T.H. Chan School of Public Health,Boston,MA,USA.1Department of Nutrition,School of Public Health,University of São Paulo,Avenida Dr Arnaldo 715,São Paulo,SP01246-904,Brazil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30819263

Citation

Silva, Lara Ls, et al. "Serum Folate and Vitamin B12 Status in Young Brazilian Children." Public Health Nutrition, vol. 22, no. 7, 2019, pp. 1223-1231.
Silva LL, Fawzi WW, Cardoso MA, et al. Serum folate and vitamin B12 status in young Brazilian children. Public Health Nutr. 2019;22(7):1223-1231.
Silva, L. L., Fawzi, W. W., & Cardoso, M. A. (2019). Serum folate and vitamin B12 status in young Brazilian children. Public Health Nutrition, 22(7), 1223-1231. https://doi.org/10.1017/S1368980019000193
Silva LL, et al. Serum Folate and Vitamin B12 Status in Young Brazilian Children. Public Health Nutr. 2019;22(7):1223-1231. PubMed PMID: 30819263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum folate and vitamin B12 status in young Brazilian children. AU - Silva,Lara Ls, AU - Fawzi,Wafaie W, AU - Cardoso,Marly A, AU - ,, Y1 - 2019/03/01/ PY - 2019/3/2/pubmed PY - 2020/5/6/medline PY - 2019/3/2/entrez KW - Child health KW - Folate status KW - Nutritional anaemia KW - Nutritional status KW - Vitamin B12 status SP - 1223 EP - 1231 JF - Public health nutrition JO - Public Health Nutr VL - 22 IS - 7 N2 - OBJECTIVE: To assess the nutritional status of folate and vitamin B12 with anaemia in young children. DESIGN: A cross-sectional study was conducted at the primary health-care centres of four Brazilian cities. Folate and vitamin B12 were assessed by fluoroimmunoassay. Multilevel Poisson regression models were used to explore the association of folate and vitamin B12 status in relation to anaemia in young children. SETTING: Brazil.ParticipantsChildren (n 460) aged 11 to 15 months. RESULTS: The median (interquartile range) of serum folate was 39·7 (28·8-55·3) nmol/l and only four children presented with folate deficiency (<10 nmol/l). Surprisingly, 30·9 % of children presented with serum folate concentrations above the upper limit of detectable values by the commercial kit used for analysis. The frequency of vitamin B12 deficiency (<148 pmol/l) was 15 % and it was inversely associated with the highest tertile of serum folate concentrations (P<0·001). Having high serum folate concentration (≥50·1 nmol/l) and vitamin B12≥148 pmol/l was associated with lower frequency of anaemia in these children (prevalence ratio=0·53; 95% CI 0·30, 0·92). CONCLUSIONS: High frequency of elevated serum concentration of folate was found among young Brazilian children and 15 % of them had vitamin B12 deficiency. The combination of high serum folate and normal vitamin B12 status was associated with a lower frequency of anaemia in these children. Improvements in the current strategies to promote healthy food-based complementary feeding along with prevention and control of micronutrient deficiencies are recommended to improve children's health. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/30819263/Serum_folate_and_vitamin_B12_status_in_young_Brazilian_children_ L2 - https://www.cambridge.org/core/product/identifier/S1368980019000193/type/journal_article DB - PRIME DP - Unbound Medicine ER -