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Association between dietary iron and zinc intake and development of ulcerative colitis: A case-control study in Japan.
J Gastroenterol Hepatol. 2019 Oct; 34(10):1703-1710.JG

Abstract

BACKGROUND AND AIM

The prevalence of ulcerative colitis (UC) has been increasing in Japan. Trace elements, such as iron, zinc, magnesium, and copper, can cause digestive symptoms where there is a deficiency or excess. We focused on the dietary intake of trace elements and their associations with UC development.

METHODS

A multicenter, hospital-based case-control study was conducted in Japan. Cases were 127 newly diagnosed UC patients, and 171 age-matched and sex-matched hospital controls were recruited. We considered that UC patients had potentially changed their dietary habits due to disease symptoms. The dietary habits were investigated using a self-administered diet history questionnaire to analyze the dietary intakes and frequencies at two points, the previous 1 month and 1 year before.

RESULTS

In the assessment of dietary habits 1 year before, the highest intake of iron showed an increased odds ratio (OR) for UC on multivariate analysis (OR = 4.05, 95% confidence interval, 1.46-11.2, P < 0.01). The highest intake of zinc 1 year before showed a decreased OR for UC (OR = 0.39, 95% confidence interval, 0.18-0.85, P = 0.01). Intakes of magnesium and copper had no significant association with UC. Because most UC cases had experienced the first symptom of UC within the previous 11 months, these intakes at 1 year before represented an association with pre-illness dietary habits.

CONCLUSION

A high intake of iron has some effect on the development of UC. In contrast, a high intake of zinc has a protective effect on the development of UC.

Authors+Show Affiliations

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan.Osaka City University Hospital Administration Division, Osaka, Japan.Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan.Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.Department of Internal Medicine, Sakura Medical Center, Toho University, Chiba, Japan.Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan. College of Healthcare Management, Fukuoka, Japan.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

30821862

Citation

Kobayashi, Yumie, et al. "Association Between Dietary Iron and Zinc Intake and Development of Ulcerative Colitis: a Case-control Study in Japan." Journal of Gastroenterology and Hepatology, vol. 34, no. 10, 2019, pp. 1703-1710.
Kobayashi Y, Ohfuji S, Kondo K, et al. Association between dietary iron and zinc intake and development of ulcerative colitis: A case-control study in Japan. J Gastroenterol Hepatol. 2019;34(10):1703-1710.
Kobayashi, Y., Ohfuji, S., Kondo, K., Fukushima, W., Sasaki, S., Kamata, N., Yamagami, H., Fujiwara, Y., Suzuki, Y., & Hirota, Y. (2019). Association between dietary iron and zinc intake and development of ulcerative colitis: A case-control study in Japan. Journal of Gastroenterology and Hepatology, 34(10), 1703-1710. https://doi.org/10.1111/jgh.14642
Kobayashi Y, et al. Association Between Dietary Iron and Zinc Intake and Development of Ulcerative Colitis: a Case-control Study in Japan. J Gastroenterol Hepatol. 2019;34(10):1703-1710. PubMed PMID: 30821862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dietary iron and zinc intake and development of ulcerative colitis: A case-control study in Japan. AU - Kobayashi,Yumie, AU - Ohfuji,Satoko, AU - Kondo,Kyoko, AU - Fukushima,Wakaba, AU - Sasaki,Satoshi, AU - Kamata,Noriko, AU - Yamagami,Hirokazu, AU - Fujiwara,Yasuhiro, AU - Suzuki,Yasuo, AU - Hirota,Yoshio, AU - ,, Y1 - 2019/03/21/ PY - 2018/11/28/received PY - 2019/02/11/revised PY - 2019/02/27/accepted PY - 2019/3/2/pubmed PY - 2020/5/6/medline PY - 2019/3/2/entrez KW - case-control study KW - dietary iron intake KW - dietary zinc intake KW - ulcerative colitis SP - 1703 EP - 1710 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 34 IS - 10 N2 - BACKGROUND AND AIM: The prevalence of ulcerative colitis (UC) has been increasing in Japan. Trace elements, such as iron, zinc, magnesium, and copper, can cause digestive symptoms where there is a deficiency or excess. We focused on the dietary intake of trace elements and their associations with UC development. METHODS: A multicenter, hospital-based case-control study was conducted in Japan. Cases were 127 newly diagnosed UC patients, and 171 age-matched and sex-matched hospital controls were recruited. We considered that UC patients had potentially changed their dietary habits due to disease symptoms. The dietary habits were investigated using a self-administered diet history questionnaire to analyze the dietary intakes and frequencies at two points, the previous 1 month and 1 year before. RESULTS: In the assessment of dietary habits 1 year before, the highest intake of iron showed an increased odds ratio (OR) for UC on multivariate analysis (OR = 4.05, 95% confidence interval, 1.46-11.2, P < 0.01). The highest intake of zinc 1 year before showed a decreased OR for UC (OR = 0.39, 95% confidence interval, 0.18-0.85, P = 0.01). Intakes of magnesium and copper had no significant association with UC. Because most UC cases had experienced the first symptom of UC within the previous 11 months, these intakes at 1 year before represented an association with pre-illness dietary habits. CONCLUSION: A high intake of iron has some effect on the development of UC. In contrast, a high intake of zinc has a protective effect on the development of UC. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/30821862/Association_between_dietary_iron_and_zinc_intake_and_development_of_ulcerative_colitis:_A_case_control_study_in_Japan_ L2 - https://doi.org/10.1111/jgh.14642 DB - PRIME DP - Unbound Medicine ER -