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The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.
Br J Pharmacol. 1986 Jan; 87(1):109-15.BJ

Abstract

The effects of aspirin, carboxyheptylimidazole (CHI) and creatine phosphate/creatine phosphokinase (CP/CPK) on platelet aggregation and thromboxane B2 (TxB2) formation induced by collagen have been examined in vitro. Platelets from two species, man and the rat, have been used. In man, aspirin and CHI abolished TxB2 production but only partially inhibited aggregation. CP/CPK partially inhibited aggregation and TxB2 formation. In the rat, aspirin and CHI abolished TxB2 formation but had no effect on aggregation. CP/CPK completely inhibited aggregation and partially inhibited TxB2 generation. In man, collagen-induced aggregation is largely dependent on ADP and to a lesser extent on arachidonate metabolites whereas, in the rat, ADP alone mediates aggregation induced by this agonist. The results with CP/CPK suggest that TxB2 formation is dependent either on the prior release of platelet ADP or on aggregation itself rather than being responsible for the aggregation response.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3082399

Citation

Emms, H, and G P. Lewis. "The Roles of Prostaglandin Endoperoxides, Thromboxane A2 and Adenosine Diphosphate in Collagen-induced Aggregation in Man and the Rat." British Journal of Pharmacology, vol. 87, no. 1, 1986, pp. 109-15.
Emms H, Lewis GP. The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat. Br J Pharmacol. 1986;87(1):109-15.
Emms, H., & Lewis, G. P. (1986). The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat. British Journal of Pharmacology, 87(1), 109-15.
Emms H, Lewis GP. The Roles of Prostaglandin Endoperoxides, Thromboxane A2 and Adenosine Diphosphate in Collagen-induced Aggregation in Man and the Rat. Br J Pharmacol. 1986;87(1):109-15. PubMed PMID: 3082399.
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TY - JOUR T1 - The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat. AU - Emms,H, AU - Lewis,G P, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 109 EP - 15 JF - British journal of pharmacology JO - Br J Pharmacol VL - 87 IS - 1 N2 - The effects of aspirin, carboxyheptylimidazole (CHI) and creatine phosphate/creatine phosphokinase (CP/CPK) on platelet aggregation and thromboxane B2 (TxB2) formation induced by collagen have been examined in vitro. Platelets from two species, man and the rat, have been used. In man, aspirin and CHI abolished TxB2 production but only partially inhibited aggregation. CP/CPK partially inhibited aggregation and TxB2 formation. In the rat, aspirin and CHI abolished TxB2 formation but had no effect on aggregation. CP/CPK completely inhibited aggregation and partially inhibited TxB2 generation. In man, collagen-induced aggregation is largely dependent on ADP and to a lesser extent on arachidonate metabolites whereas, in the rat, ADP alone mediates aggregation induced by this agonist. The results with CP/CPK suggest that TxB2 formation is dependent either on the prior release of platelet ADP or on aggregation itself rather than being responsible for the aggregation response. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/3082399/The_roles_of_prostaglandin_endoperoxides_thromboxane_A2_and_adenosine_diphosphate_in_collagen_induced_aggregation_in_man_and_the_rat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1986&volume=87&issue=1&spage=109 DB - PRIME DP - Unbound Medicine ER -