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Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials.
Br J Sports Med. 2020 May; 54(10):573-581.BJ

Abstract

OBJECTIVE

To determine the effects of multi-ingredient protein (MIP) supplements on resistance exercise training (RT)-induced gains in muscle mass and strength compared with protein-only (PRO) or placebo supplementation.

DATA SOURCES

Systematic search of MEDLINE, Embase, CINAHL and SPORTDiscus.

ELIGIBILITY CRITERIA

Randomised controlled trials with interventions including RT ≥6 weeks in duration and a MIP supplement.

DESIGN

Random effects meta-analyses were conducted to determine the effect of supplementation on fat-free mass (FFM), fat mass, one-repetition maximum (1RM) upper body and 1RM lower body muscular strength. Subgroup analyses compared the efficacy of MIP supplementation relative to training status and chronological age.

RESULTS

The most common MIP supplements included protein with creatine (n=17) or vitamin D (n=10). Data from 35 trials with 1387 participants showed significant (p<0.05) increases in FFM (0.80 kg (95% CI 0.44 to 1.15)), 1RM lower body (4.22 kg (95% CI 0.79 to 7.64)) and 1RM upper body (2.56 kg (95% CI 0.79 to 4.33)) where a supplement was compared with all non-MIP supplemented conditions (means (95% CI)). Subgroup analyses indicated a greater effect of MIP supplements compared with all non-MIP supplements on FFM in untrained (0.95 kg (95% CI 0.51 to 1.39), p<0.0001) and older participants (0.77 kg (95% CI 0.11 to 1.43), p=0.02); taking MIP supplements was also associated with gains in 1RM upper body (1.56 kg (95% CI 0.80 to 2.33), p=0.01) in older adults.

SUMMARY/CONCLUSIONS

When MIP supplements were combined with resistance exercise training, there were greater gains in FFM and strength in healthy adults than in counterparts who were supplemented with non-MIP. MIP supplements were not superior when directly compared with PRO supplements. The magnitude of effect of MIP supplements was greater (in absolute values) in untrained and elderly individuals undertaking RT than it was in trained individuals and in younger people.

TRIAL REGISTRATION NUMBER

CRD42017081970.

Authors+Show Affiliations

Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30824459

Citation

O'Bryan, Kerry R., et al. "Do Multi-ingredient Protein Supplements Augment Resistance Training-induced Gains in Skeletal Muscle Mass and Strength? a Systematic Review and Meta-analysis of 35 Trials." British Journal of Sports Medicine, vol. 54, no. 10, 2020, pp. 573-581.
O'Bryan KR, Doering TM, Morton RW, et al. Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials. Br J Sports Med. 2020;54(10):573-581.
O'Bryan, K. R., Doering, T. M., Morton, R. W., Coffey, V. G., Phillips, S. M., & Cox, G. R. (2020). Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials. British Journal of Sports Medicine, 54(10), 573-581. https://doi.org/10.1136/bjsports-2018-099889
O'Bryan KR, et al. Do Multi-ingredient Protein Supplements Augment Resistance Training-induced Gains in Skeletal Muscle Mass and Strength? a Systematic Review and Meta-analysis of 35 Trials. Br J Sports Med. 2020;54(10):573-581. PubMed PMID: 30824459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials. AU - O'Bryan,Kerry R, AU - Doering,Thomas M, AU - Morton,Robert W, AU - Coffey,Vernon G, AU - Phillips,Stuart M, AU - Cox,Gregory R, Y1 - 2019/03/01/ PY - 2019/02/08/accepted PY - 2019/3/3/pubmed PY - 2020/7/7/medline PY - 2019/3/3/entrez KW - muscle KW - protein KW - strength KW - supplements SP - 573 EP - 581 JF - British journal of sports medicine JO - Br J Sports Med VL - 54 IS - 10 N2 - OBJECTIVE: To determine the effects of multi-ingredient protein (MIP) supplements on resistance exercise training (RT)-induced gains in muscle mass and strength compared with protein-only (PRO) or placebo supplementation. DATA SOURCES: Systematic search of MEDLINE, Embase, CINAHL and SPORTDiscus. ELIGIBILITY CRITERIA: Randomised controlled trials with interventions including RT ≥6 weeks in duration and a MIP supplement. DESIGN: Random effects meta-analyses were conducted to determine the effect of supplementation on fat-free mass (FFM), fat mass, one-repetition maximum (1RM) upper body and 1RM lower body muscular strength. Subgroup analyses compared the efficacy of MIP supplementation relative to training status and chronological age. RESULTS: The most common MIP supplements included protein with creatine (n=17) or vitamin D (n=10). Data from 35 trials with 1387 participants showed significant (p<0.05) increases in FFM (0.80 kg (95% CI 0.44 to 1.15)), 1RM lower body (4.22 kg (95% CI 0.79 to 7.64)) and 1RM upper body (2.56 kg (95% CI 0.79 to 4.33)) where a supplement was compared with all non-MIP supplemented conditions (means (95% CI)). Subgroup analyses indicated a greater effect of MIP supplements compared with all non-MIP supplements on FFM in untrained (0.95 kg (95% CI 0.51 to 1.39), p<0.0001) and older participants (0.77 kg (95% CI 0.11 to 1.43), p=0.02); taking MIP supplements was also associated with gains in 1RM upper body (1.56 kg (95% CI 0.80 to 2.33), p=0.01) in older adults. SUMMARY/CONCLUSIONS: When MIP supplements were combined with resistance exercise training, there were greater gains in FFM and strength in healthy adults than in counterparts who were supplemented with non-MIP. MIP supplements were not superior when directly compared with PRO supplements. The magnitude of effect of MIP supplements was greater (in absolute values) in untrained and elderly individuals undertaking RT than it was in trained individuals and in younger people. TRIAL REGISTRATION NUMBER: CRD42017081970. SN - 1473-0480 UR - https://www.unboundmedicine.com/medline/citation/30824459/Do_multi_ingredient_protein_supplements_augment_resistance_training_induced_gains_in_skeletal_muscle_mass_and_strength_A_systematic_review_and_meta_analysis_of_35_trials_ L2 - https://bjsm.bmj.com/lookup/pmidlookup?view=long&amp;pmid=30824459 DB - PRIME DP - Unbound Medicine ER -