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Vitamin B12 and folate status in Spanish lacto-ovo vegetarians and vegans.
J Nutr Sci. 2019; 8:e7.JN

Abstract

Studies on the nutritional status of vegetarians in Spain are lacking. Prevention of vitamin B12 deficiency is the main concern, as dietary sources are of animal origin. The present study aimed to evaluate vitamin B12 and folate status of Spanish vegetarians using classical markers and functional markers. Participants were adult and healthy lacto-ovo vegetarians (forty-nine subjects) and vegans (fifty-four subjects) who underwent blood analyses and completed a FFQ. Serum vitamin B12, homocysteine (Hcy), methylmalonic acid (MMA), erythrocyte folate and haematological parameters were determined. The effects of the type of plant-based diet, and the intake of supplements and foods were studied by a FFQ. Mean erythrocyte folate was 1704 (sd 609) nmol/l. Clinical or subclinical vitamin B12 deficiency was detected in 11 % of the subjects (MMA>271 nmol/l) and 33 % of the participants showed hyperhomocysteinaemia (Hcy>15 µmol/l). Regarding plant-based diet type, significantly higher Hcy was observed in lacto-ovo vegetarians compared with vegans (P = 0·019). Moreover, use of vitamin B12 supplements involved an improvement of vitamin B12 status but further increase in erythrocyte folate (P = 0·024). Consumption of yoghurts was weakly associated with serum vitamin B12 adequacy (P = 0·049) and that of eggs with lower Hcy (P = 0·030). In conclusion, Spanish vegetarians present high folate status but vitamin B12 subclinical deficiency was demonstrated using functional markers. The lack of influence of dietary sources on functional markers and the strong effect of vitamin B12 supplement intake emphasise the need of cobalamin supplementation in both lacto-ovo vegetarians and vegans.

Authors+Show Affiliations

Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040 Madrid, Spain.Statistics Department, Computing Center (SGAI-CSIC), Pinar 19, 28006 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040 Madrid, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30828450

Citation

Gallego-Narbón, Angélica, et al. "Vitamin B12 and Folate Status in Spanish Lacto-ovo Vegetarians and Vegans." Journal of Nutritional Science, vol. 8, 2019, pp. e7.
Gallego-Narbón A, Zapatera B, Barrios L, et al. Vitamin B12 and folate status in Spanish lacto-ovo vegetarians and vegans. J Nutr Sci. 2019;8:e7.
Gallego-Narbón, A., Zapatera, B., Barrios, L., & Vaquero, M. P. (2019). Vitamin B12 and folate status in Spanish lacto-ovo vegetarians and vegans. Journal of Nutritional Science, 8, e7. https://doi.org/10.1017/jns.2019.2
Gallego-Narbón A, et al. Vitamin B12 and Folate Status in Spanish Lacto-ovo Vegetarians and Vegans. J Nutr Sci. 2019;8:e7. PubMed PMID: 30828450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 and folate status in Spanish lacto-ovo vegetarians and vegans. AU - Gallego-Narbón,Angélica, AU - Zapatera,Belén, AU - Barrios,Laura, AU - Vaquero,M Pilar, Y1 - 2019/02/26/ PY - 2018/12/10/received PY - 2019/01/16/accepted PY - 2019/3/5/entrez PY - 2019/3/5/pubmed PY - 2019/3/5/medline KW - Folate KW - HHcy, hyperhomocysteinaemia KW - Hcy, homocysteine KW - MCH, mean corpuscular Hb KW - MCV, mean corpuscular erythrocyte volume KW - MMA, methylmalonic acid KW - Supplementation KW - Vegans KW - Vegetarians KW - Vitamin B12 SP - e7 EP - e7 JF - Journal of nutritional science JO - J Nutr Sci VL - 8 N2 - Studies on the nutritional status of vegetarians in Spain are lacking. Prevention of vitamin B12 deficiency is the main concern, as dietary sources are of animal origin. The present study aimed to evaluate vitamin B12 and folate status of Spanish vegetarians using classical markers and functional markers. Participants were adult and healthy lacto-ovo vegetarians (forty-nine subjects) and vegans (fifty-four subjects) who underwent blood analyses and completed a FFQ. Serum vitamin B12, homocysteine (Hcy), methylmalonic acid (MMA), erythrocyte folate and haematological parameters were determined. The effects of the type of plant-based diet, and the intake of supplements and foods were studied by a FFQ. Mean erythrocyte folate was 1704 (sd 609) nmol/l. Clinical or subclinical vitamin B12 deficiency was detected in 11 % of the subjects (MMA>271 nmol/l) and 33 % of the participants showed hyperhomocysteinaemia (Hcy>15 µmol/l). Regarding plant-based diet type, significantly higher Hcy was observed in lacto-ovo vegetarians compared with vegans (P = 0·019). Moreover, use of vitamin B12 supplements involved an improvement of vitamin B12 status but further increase in erythrocyte folate (P = 0·024). Consumption of yoghurts was weakly associated with serum vitamin B12 adequacy (P = 0·049) and that of eggs with lower Hcy (P = 0·030). In conclusion, Spanish vegetarians present high folate status but vitamin B12 subclinical deficiency was demonstrated using functional markers. The lack of influence of dietary sources on functional markers and the strong effect of vitamin B12 supplement intake emphasise the need of cobalamin supplementation in both lacto-ovo vegetarians and vegans. SN - 2048-6790 UR - https://www.unboundmedicine.com/medline/citation/30828450/Vitamin_B12_and_folate_status_in_Spanish_lacto_ovo_vegetarians_and_vegans_ L2 - https://www.cambridge.org/core/product/identifier/00002/type/journal_article DB - PRIME DP - Unbound Medicine ER -