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Characteristics of coronary artery disease in chronic kidney disease.
Clin Exp Nephrol. 2019 Jun; 23(6):725-732.CE

Abstract

Patients with chronic kidney disease (CKD) commonly experience cardiovascular disease (CVD), and a major cause of death in these patients is CVD. Therefore, the prevention of CVD progression is very crucial in patients with CKD. Recently, this relationship between CKD and CVD has increasingly been examined, and a concept termed "cardiorenal syndrome" has been advocated. Coronary artery disease (CAD) and myocardial injury are crucial factors that contribute to the occurrence of CVD. The initial step CAD is endothelial dysfunction that can be detected as a decrease in the coronary flow reserve (CFR). The previous studies have reported that decreased CFR is significantly correlated to coronary events and mortality. Furthermore, CFR reduces with a decline in the kidney function. Another important presentation of CAD is coronary artery calcification. Vascular calcification is a crucial pathophysiological state, particularly in patients with CKD, and it affects the stability of coronary atherosclerotic plaque. In CKD, not only the traditional risk factors but also CKD-related non-traditional risk factors play key roles in CVD progression. Therefore, the mechanisms responsible for CVD progression are very complex; however, their clarification is crucial to improve the prognosis in patients with CKD.

Authors+Show Affiliations

Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan. fhideki@med.kobe-u.ac.jp.Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30830548

Citation

Fujii, Hideki, et al. "Characteristics of Coronary Artery Disease in Chronic Kidney Disease." Clinical and Experimental Nephrology, vol. 23, no. 6, 2019, pp. 725-732.
Fujii H, Kono K, Nishi S. Characteristics of coronary artery disease in chronic kidney disease. Clin Exp Nephrol. 2019;23(6):725-732.
Fujii, H., Kono, K., & Nishi, S. (2019). Characteristics of coronary artery disease in chronic kidney disease. Clinical and Experimental Nephrology, 23(6), 725-732. https://doi.org/10.1007/s10157-019-01718-5
Fujii H, Kono K, Nishi S. Characteristics of Coronary Artery Disease in Chronic Kidney Disease. Clin Exp Nephrol. 2019;23(6):725-732. PubMed PMID: 30830548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of coronary artery disease in chronic kidney disease. AU - Fujii,Hideki, AU - Kono,Keiji, AU - Nishi,Shinichi, Y1 - 2019/03/04/ PY - 2018/12/01/received PY - 2019/02/07/accepted PY - 2019/3/5/pubmed PY - 2019/12/18/medline PY - 2019/3/5/entrez KW - Cardiovascular disease KW - Chronic kidney disease KW - Coronary artery disease SP - 725 EP - 732 JF - Clinical and experimental nephrology JO - Clin Exp Nephrol VL - 23 IS - 6 N2 - Patients with chronic kidney disease (CKD) commonly experience cardiovascular disease (CVD), and a major cause of death in these patients is CVD. Therefore, the prevention of CVD progression is very crucial in patients with CKD. Recently, this relationship between CKD and CVD has increasingly been examined, and a concept termed "cardiorenal syndrome" has been advocated. Coronary artery disease (CAD) and myocardial injury are crucial factors that contribute to the occurrence of CVD. The initial step CAD is endothelial dysfunction that can be detected as a decrease in the coronary flow reserve (CFR). The previous studies have reported that decreased CFR is significantly correlated to coronary events and mortality. Furthermore, CFR reduces with a decline in the kidney function. Another important presentation of CAD is coronary artery calcification. Vascular calcification is a crucial pathophysiological state, particularly in patients with CKD, and it affects the stability of coronary atherosclerotic plaque. In CKD, not only the traditional risk factors but also CKD-related non-traditional risk factors play key roles in CVD progression. Therefore, the mechanisms responsible for CVD progression are very complex; however, their clarification is crucial to improve the prognosis in patients with CKD. SN - 1437-7799 UR - https://www.unboundmedicine.com/medline/citation/30830548/Characteristics_of_coronary_artery_disease_in_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s10157-019-01718-5 DB - PRIME DP - Unbound Medicine ER -