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Prenatal exposure to benzophenones, parabens and triclosan and neurocognitive development at 2 years.
Environ Int. 2019 05; 126:413-421.EI

Abstract

BACKGROUND

Benzophenones (BPs), parabens, and triclosan (TCS) are widely used in personal care products and may be neurotoxic to children, but limited studies have estimated the associations between exposure to these potential endocrine disrupting chemicals during pregnancy and child neurocognitive development.

OBJECTIVE

Our aim was to evaluate the relationships of prenatal exposure to BPs, parabens and TCS with child neurocognitive development at age 2.

METHODS

From 2014 to 2015, 478 mother-child pairs from a longitudinal prenatal cohort in China were included in present study. We quantified BPs, parabens and TCS in three spot urine samples during pregnancy (in the first, second, and third trimester). The Bayley Scales of Infant Development (BSID) test to children was performed at 2 years. Multivariate linear regression models and generalized estimating equations were used to examine changes in mental developmental index (MDI) and psychomotor development index (PDI) per 2-fold increase in averaged and trimester-specific maternal urinary phenols, respectively.

RESULTS

In the adjusted models, each 2-fold increase in average prenatal paraben concentration was associated with lower MDI scores among girls [-1.08 (95% CI: -2.10, -0.06) and - 1.51 (95% CI: -2.69, -0.32) for methyl paraben (Mep) and Σparabens, respectively], but the association was not statistically significant among boys [-0.24 (95% CI: -1.46, 0.99), Psex-int = 0.37 and 0.18 (95% CI: -1.28, 1.64), Psex-int = 0.10 for Mep and Σparabens, respectively]. Increasing urinary 4-hydroxybenzophenone (4-OH-BP) concentration was associated with lower PDI scores among boys [-2.96 (95% CI: -4.48, -1.45)], not girls [-0.07 (95% CI: -1.57, 1.43)] and the association was significantly different in boys and girls (Psex-int = 0.01). No significant associations were observed between the average prenatal TCS exposure and BSID results. In trimester-specific analyses, increasing parabens was associated with lower girls' MDI only in the second trimester, while increasing 4-OH-BP was associated with lower boys' PDI in each trimester.

CONCLUSION

Our results suggest that prenatal exposure to BPs and parabens may be associated with impairment in child cognitive abilities at 2 years. Further human and animal studies are needed to verify our results and elucidate the biological mechanisms involved in these associations.

Authors+Show Affiliations

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, People's Republic of China.Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address: zwcai@hkbu.edu.hk.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: xust@hust.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30831476

Citation

Jiang, Yangqian, et al. "Prenatal Exposure to Benzophenones, Parabens and Triclosan and Neurocognitive Development at 2 Years." Environment International, vol. 126, 2019, pp. 413-421.
Jiang Y, Zhao H, Xia W, et al. Prenatal exposure to benzophenones, parabens and triclosan and neurocognitive development at 2 years. Environ Int. 2019;126:413-421.
Jiang, Y., Zhao, H., Xia, W., Li, Y., Liu, H., Hao, K., Chen, J., Sun, X., Liu, W., Li, J., Peng, Y., Hu, C., Li, C., Zhang, B., Lu, S., Cai, Z., & Xu, S. (2019). Prenatal exposure to benzophenones, parabens and triclosan and neurocognitive development at 2 years. Environment International, 126, 413-421. https://doi.org/10.1016/j.envint.2019.01.023
Jiang Y, et al. Prenatal Exposure to Benzophenones, Parabens and Triclosan and Neurocognitive Development at 2 Years. Environ Int. 2019;126:413-421. PubMed PMID: 30831476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to benzophenones, parabens and triclosan and neurocognitive development at 2 years. AU - Jiang,Yangqian, AU - Zhao,Hongzhi, AU - Xia,Wei, AU - Li,Yuanyuan, AU - Liu,Hongxiu, AU - Hao,Ke, AU - Chen,Jia, AU - Sun,Xiaojie, AU - Liu,Wenyu, AU - Li,Jiufeng, AU - Peng,Yang, AU - Hu,Chen, AU - Li,Chunhui, AU - Zhang,Bin, AU - Lu,Shi, AU - Cai,Zongwei, AU - Xu,Shunqing, Y1 - 2019/03/02/ PY - 2018/10/08/received PY - 2019/01/08/revised PY - 2019/01/09/accepted PY - 2019/3/5/pubmed PY - 2019/10/31/medline PY - 2019/3/5/entrez KW - Benzophenones KW - Child neurocognitive development KW - Parabens KW - Triclosan SP - 413 EP - 421 JF - Environment international JO - Environ Int VL - 126 N2 - BACKGROUND: Benzophenones (BPs), parabens, and triclosan (TCS) are widely used in personal care products and may be neurotoxic to children, but limited studies have estimated the associations between exposure to these potential endocrine disrupting chemicals during pregnancy and child neurocognitive development. OBJECTIVE: Our aim was to evaluate the relationships of prenatal exposure to BPs, parabens and TCS with child neurocognitive development at age 2. METHODS: From 2014 to 2015, 478 mother-child pairs from a longitudinal prenatal cohort in China were included in present study. We quantified BPs, parabens and TCS in three spot urine samples during pregnancy (in the first, second, and third trimester). The Bayley Scales of Infant Development (BSID) test to children was performed at 2 years. Multivariate linear regression models and generalized estimating equations were used to examine changes in mental developmental index (MDI) and psychomotor development index (PDI) per 2-fold increase in averaged and trimester-specific maternal urinary phenols, respectively. RESULTS: In the adjusted models, each 2-fold increase in average prenatal paraben concentration was associated with lower MDI scores among girls [-1.08 (95% CI: -2.10, -0.06) and - 1.51 (95% CI: -2.69, -0.32) for methyl paraben (Mep) and Σparabens, respectively], but the association was not statistically significant among boys [-0.24 (95% CI: -1.46, 0.99), Psex-int = 0.37 and 0.18 (95% CI: -1.28, 1.64), Psex-int = 0.10 for Mep and Σparabens, respectively]. Increasing urinary 4-hydroxybenzophenone (4-OH-BP) concentration was associated with lower PDI scores among boys [-2.96 (95% CI: -4.48, -1.45)], not girls [-0.07 (95% CI: -1.57, 1.43)] and the association was significantly different in boys and girls (Psex-int = 0.01). No significant associations were observed between the average prenatal TCS exposure and BSID results. In trimester-specific analyses, increasing parabens was associated with lower girls' MDI only in the second trimester, while increasing 4-OH-BP was associated with lower boys' PDI in each trimester. CONCLUSION: Our results suggest that prenatal exposure to BPs and parabens may be associated with impairment in child cognitive abilities at 2 years. Further human and animal studies are needed to verify our results and elucidate the biological mechanisms involved in these associations. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/30831476/Prenatal_exposure_to_benzophenones_parabens_and_triclosan_and_neurocognitive_development_at_2_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(18)32308-0 DB - PRIME DP - Unbound Medicine ER -