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Simultaneous regeneration of calcium lactate and cellulose into PCL nanofiber for biomedical application.
Carbohydr Polym 2019; 212:21-29CP

Abstract

Synthetic polymers are easy to process and have excellent mechanical properties but low wettability and poor cell compatibility limit their applications in tissue scaffolding. In this study, a facile procedure was established to regenerate cellulose and calcium lactate (CaL) into a polycaprolactone (PCL) nanofibrous scaffold for tissue engineering applications. Briefly, varying amounts of lactic acid (LA) was mixed with the blend of PCL and cellulose acetate (CA) solutions and electrospun to fabricate an optimal composite PCL/CA/LA fibrous membrane. Later on, as-prepared membranes were treated with calcium hydroxide solution. This process simultaneously converted CA and LA contents into Cellulose and CaL, respectively. In situ regeneration of Cellulose and CaL into the composite fiber remarkably enhanced the biological and physicochemical properties of the composite fiber. This work provides a novel dual-channel strategy for simultaneous regeneration of biopolymer and bioactive molecule into the PCL nanofiber for regenerative medicine and tissue engineering applications.

Authors+Show Affiliations

Department of Bionanosystem Engineering, Chonbuk National University, Jeonju, Jeonbuk, South Korea; Department of Medical Practicing, Woori Convalescent Hospital, Jeonju, Jeonbuk, South Korea.Department of Bionanosystem Engineering, Chonbuk National University, Jeonju, Jeonbuk, South Korea.Department of Chemistry, Tribhuvan University, Tri-Chandra Multiple Campus, Kathmandu, Nepal. Electronic address: joshimj@jbnu.ac.kr.Department of Bionanosystem Engineering, Chonbuk National University, Jeonju, Jeonbuk, South Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk, South Korea. Electronic address: biochan@jbnu.ac.kr.Department of Bionanosystem Engineering, Chonbuk National University, Jeonju, Jeonbuk, South Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk, South Korea. Electronic address: chskim@jbnu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30832849

Citation

Hwang, T I., et al. "Simultaneous Regeneration of Calcium Lactate and Cellulose Into PCL Nanofiber for Biomedical Application." Carbohydrate Polymers, vol. 212, 2019, pp. 21-29.
Hwang TI, Kim JI, Joshi MK, et al. Simultaneous regeneration of calcium lactate and cellulose into PCL nanofiber for biomedical application. Carbohydr Polym. 2019;212:21-29.
Hwang, T. I., Kim, J. I., Joshi, M. K., Park, C. H., & Kim, C. S. (2019). Simultaneous regeneration of calcium lactate and cellulose into PCL nanofiber for biomedical application. Carbohydrate Polymers, 212, pp. 21-29. doi:10.1016/j.carbpol.2019.01.085.
Hwang TI, et al. Simultaneous Regeneration of Calcium Lactate and Cellulose Into PCL Nanofiber for Biomedical Application. Carbohydr Polym. 2019 May 15;212:21-29. PubMed PMID: 30832849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous regeneration of calcium lactate and cellulose into PCL nanofiber for biomedical application. AU - Hwang,T I, AU - Kim,J I, AU - Joshi,Mahesh Kumar, AU - Park,Chan Hee, AU - Kim,Cheol Sang, Y1 - 2019/02/11/ PY - 2018/09/10/received PY - 2019/01/07/revised PY - 2019/01/24/accepted PY - 2019/3/6/entrez PY - 2019/3/6/pubmed PY - 2019/6/21/medline KW - Biofabrication KW - Bone tissue engineering KW - Calcium lactate KW - Cellulose nanofiber KW - Post-electrospinning process KW - Simultaneous in-situ synthesis SP - 21 EP - 29 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 212 N2 - Synthetic polymers are easy to process and have excellent mechanical properties but low wettability and poor cell compatibility limit their applications in tissue scaffolding. In this study, a facile procedure was established to regenerate cellulose and calcium lactate (CaL) into a polycaprolactone (PCL) nanofibrous scaffold for tissue engineering applications. Briefly, varying amounts of lactic acid (LA) was mixed with the blend of PCL and cellulose acetate (CA) solutions and electrospun to fabricate an optimal composite PCL/CA/LA fibrous membrane. Later on, as-prepared membranes were treated with calcium hydroxide solution. This process simultaneously converted CA and LA contents into Cellulose and CaL, respectively. In situ regeneration of Cellulose and CaL into the composite fiber remarkably enhanced the biological and physicochemical properties of the composite fiber. This work provides a novel dual-channel strategy for simultaneous regeneration of biopolymer and bioactive molecule into the PCL nanofiber for regenerative medicine and tissue engineering applications. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/30832849/Simultaneous_regeneration_of_calcium_lactate_and_cellulose_into_PCL_nanofiber_for_biomedical_application_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(19)30097-9 DB - PRIME DP - Unbound Medicine ER -