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[Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine].
Arzneimittelforschung. 1986 Feb; 36(2):265-8.A

Abstract

The deleterious effects of acetylsalicylic acid (ASA) on gastric mucosa have been well documented in experimental and clinical studies. With a direct endoscopic assay system we evaluated in healthy volunteers whether pretreatment with prostaglandin analogues (misoprostol, rioprostil), omeprazole and ranitidine prevented ASA-induced gastric mucosal injuries. Ranitidine (2 X 150 mg/d) in large antisecretory doses almost completely abolished these changes (p less than 0.05). By contrast, misoprostol (4 X 50 micrograms/d and 4 X 200 micrograms/d), rioprostil (3 X 100 micrograms/d), omeprazole (5 mg and 10 mg/d) as well as ranitidine in non-antisecretory doses (2 X 25 mg/d) did not reduce gastric mucosal injury after single-dose ASA administration. The results of this trial indicate that socalled cytoprotective doses of prostaglandins, omeprazole and ranitidine in contrast to animal findings are not effective in preventing acute ASA-induced mucosal damage.

Authors

Müller P
No affiliation info available
Dammann HG
No affiliation info available
Simon B
No affiliation info available

MeSH

AdultAlprostadilAnti-Ulcer AgentsAspirinBenzimidazolesClinical Trials as TopicDouble-Blind MethodGastric MucosaGastroscopyHumansMisoprostolOmeprazoleProstaglandins EProstaglandins, SyntheticRandom AllocationRanitidineRioprostilStomach Ulcer

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
English Abstract
Journal Article

Language

ger

PubMed ID

3083829

Citation

Müller, P, et al. "[Acute Injury to the Gastric Mucosa By Acetylsalicylic Acid. a Comparative Endoscopic Study in Man With Oral Prostaglandin Analogs, Omeprazole and Ranitidine]." Arzneimittel-Forschung, vol. 36, no. 2, 1986, pp. 265-8.
Müller P, Dammann HG, Simon B. [Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. Arzneimittelforschung. 1986;36(2):265-8.
Müller, P., Dammann, H. G., & Simon, B. (1986). [Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. Arzneimittel-Forschung, 36(2), 265-8.
Müller P, Dammann HG, Simon B. [Acute Injury to the Gastric Mucosa By Acetylsalicylic Acid. a Comparative Endoscopic Study in Man With Oral Prostaglandin Analogs, Omeprazole and Ranitidine]. Arzneimittelforschung. 1986;36(2):265-8. PubMed PMID: 3083829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. AU - Müller,P, AU - Dammann,H G, AU - Simon,B, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 265 EP - 8 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 36 IS - 2 N2 - The deleterious effects of acetylsalicylic acid (ASA) on gastric mucosa have been well documented in experimental and clinical studies. With a direct endoscopic assay system we evaluated in healthy volunteers whether pretreatment with prostaglandin analogues (misoprostol, rioprostil), omeprazole and ranitidine prevented ASA-induced gastric mucosal injuries. Ranitidine (2 X 150 mg/d) in large antisecretory doses almost completely abolished these changes (p less than 0.05). By contrast, misoprostol (4 X 50 micrograms/d and 4 X 200 micrograms/d), rioprostil (3 X 100 micrograms/d), omeprazole (5 mg and 10 mg/d) as well as ranitidine in non-antisecretory doses (2 X 25 mg/d) did not reduce gastric mucosal injury after single-dose ASA administration. The results of this trial indicate that socalled cytoprotective doses of prostaglandins, omeprazole and ranitidine in contrast to animal findings are not effective in preventing acute ASA-induced mucosal damage. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3083829/[Acute_injury_to_the_gastric_mucosa_by_acetylsalicylic_acid__A_comparative_endoscopic_study_in_man_with_oral_prostaglandin_analogs_omeprazole_and_ranitidine]_ DB - PRIME DP - Unbound Medicine ER -