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[Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine].
Arzneimittelforschung. 1986 Feb; 36(2):265-8.A

Abstract

The deleterious effects of acetylsalicylic acid (ASA) on gastric mucosa have been well documented in experimental and clinical studies. With a direct endoscopic assay system we evaluated in healthy volunteers whether pretreatment with prostaglandin analogues (misoprostol, rioprostil), omeprazole and ranitidine prevented ASA-induced gastric mucosal injuries. Ranitidine (2 X 150 mg/d) in large antisecretory doses almost completely abolished these changes (p less than 0.05). By contrast, misoprostol (4 X 50 micrograms/d and 4 X 200 micrograms/d), rioprostil (3 X 100 micrograms/d), omeprazole (5 mg and 10 mg/d) as well as ranitidine in non-antisecretory doses (2 X 25 mg/d) did not reduce gastric mucosal injury after single-dose ASA administration. The results of this trial indicate that socalled cytoprotective doses of prostaglandins, omeprazole and ranitidine in contrast to animal findings are not effective in preventing acute ASA-induced mucosal damage.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
English Abstract
Journal Article

Language

ger

PubMed ID

3083829

Citation

Müller, P, et al. "[Acute Injury to the Gastric Mucosa By Acetylsalicylic Acid. a Comparative Endoscopic Study in Man With Oral Prostaglandin Analogs, Omeprazole and Ranitidine]." Arzneimittel-Forschung, vol. 36, no. 2, 1986, pp. 265-8.
Müller P, Dammann HG, Simon B. [Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. Arzneimittelforschung. 1986;36(2):265-8.
Müller, P., Dammann, H. G., & Simon, B. (1986). [Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. Arzneimittel-Forschung, 36(2), 265-8.
Müller P, Dammann HG, Simon B. [Acute Injury to the Gastric Mucosa By Acetylsalicylic Acid. a Comparative Endoscopic Study in Man With Oral Prostaglandin Analogs, Omeprazole and Ranitidine]. Arzneimittelforschung. 1986;36(2):265-8. PubMed PMID: 3083829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. AU - Müller,P, AU - Dammann,H G, AU - Simon,B, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 265 EP - 8 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 36 IS - 2 N2 - The deleterious effects of acetylsalicylic acid (ASA) on gastric mucosa have been well documented in experimental and clinical studies. With a direct endoscopic assay system we evaluated in healthy volunteers whether pretreatment with prostaglandin analogues (misoprostol, rioprostil), omeprazole and ranitidine prevented ASA-induced gastric mucosal injuries. Ranitidine (2 X 150 mg/d) in large antisecretory doses almost completely abolished these changes (p less than 0.05). By contrast, misoprostol (4 X 50 micrograms/d and 4 X 200 micrograms/d), rioprostil (3 X 100 micrograms/d), omeprazole (5 mg and 10 mg/d) as well as ranitidine in non-antisecretory doses (2 X 25 mg/d) did not reduce gastric mucosal injury after single-dose ASA administration. The results of this trial indicate that socalled cytoprotective doses of prostaglandins, omeprazole and ranitidine in contrast to animal findings are not effective in preventing acute ASA-induced mucosal damage. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3083829/[Acute_injury_to_the_gastric_mucosa_by_acetylsalicylic_acid__A_comparative_endoscopic_study_in_man_with_oral_prostaglandin_analogs_omeprazole_and_ranitidine]_ DB - PRIME DP - Unbound Medicine ER -