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Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation.
Am J Dermatopathol. 2019 Nov; 41(11):810-818.AJ

Abstract

INTRODUCTION

Benign cutaneous tumors with follicular differentiation are alleged to differentiate toward parts of the hair follicle. Connexin 43 (Cx43) is a gap junction protein, the tumoral role of which has been investigated in several types of tumors.

OBJECTIVE

To study the pattern of expression of Cx43 in benign cutaneous tumors with follicular differentiation and to compare it with that shown by their alleged anatomical counterparts of the hair follicle.

MATERIALS AND METHODS

Five cases each of trichofolliculoma, trichilemmoma, fibrofolliculoma/trichodiscoma, trichoblastoma, trichoepithelioma, pilomatrixoma, and proliferating trichilemmal tumor, 3 cases of pilar sheath acanthoma, and 1 case of tumor of the follicular infundibulum were examined. Anti-Cx43 antibody was used.

RESULTS

Cx43 was expressed by all follicular tumors studied. Comparisons between trichoblastoma and trichoepithelioma and their respective normal counterparts could not be made. In 3 tumors (trichofolliculoma, pilomatrixoma, and the spectrum fibrofolliculoma/trichodiscoma), there was a parallelism between their Cx43 expression pattern and that of their alleged anatomical counterparts. In pilar sheath acanthoma, trichilemmoma, and the tumor of the follicular infundibulum, we only found partial similarities in Cx43 expression. Only the proliferating trichilemmal tumor showed a discordant pattern of expression.

CONCLUSIONS

Cx43 expression is preserved in benign cutaneous tumors with follicular differentiation and the patterns of Cx43 expression in benign cutaneous tumors with follicular differentiation parallel those of their alleged anatomical counterparts in 5 types (either totally or partially). This preservation might be related to the good behavior of the entities studied.

Authors+Show Affiliations

Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain. CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain. Department of Dermatology, Universitary Hospital of A Coruña, A Coruña, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30839347

Citation

Fernandez-Flores, Angel, et al. "Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation." The American Journal of Dermatopathology, vol. 41, no. 11, 2019, pp. 810-818.
Fernandez-Flores A, Varela-Vazquez A, Mayan MD, et al. Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. Am J Dermatopathol. 2019;41(11):810-818.
Fernandez-Flores, A., Varela-Vazquez, A., Mayan, M. D., & Fonseca, E. (2019). Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. The American Journal of Dermatopathology, 41(11), 810-818. https://doi.org/10.1097/DAD.0000000000001395
Fernandez-Flores A, et al. Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. Am J Dermatopathol. 2019;41(11):810-818. PubMed PMID: 30839347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. AU - Fernandez-Flores,Angel, AU - Varela-Vazquez,Adrian, AU - Mayan,Maria D, AU - Fonseca,Eduardo, PY - 2019/3/7/pubmed PY - 2020/3/17/medline PY - 2019/3/7/entrez SP - 810 EP - 818 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 41 IS - 11 N2 - INTRODUCTION: Benign cutaneous tumors with follicular differentiation are alleged to differentiate toward parts of the hair follicle. Connexin 43 (Cx43) is a gap junction protein, the tumoral role of which has been investigated in several types of tumors. OBJECTIVE: To study the pattern of expression of Cx43 in benign cutaneous tumors with follicular differentiation and to compare it with that shown by their alleged anatomical counterparts of the hair follicle. MATERIALS AND METHODS: Five cases each of trichofolliculoma, trichilemmoma, fibrofolliculoma/trichodiscoma, trichoblastoma, trichoepithelioma, pilomatrixoma, and proliferating trichilemmal tumor, 3 cases of pilar sheath acanthoma, and 1 case of tumor of the follicular infundibulum were examined. Anti-Cx43 antibody was used. RESULTS: Cx43 was expressed by all follicular tumors studied. Comparisons between trichoblastoma and trichoepithelioma and their respective normal counterparts could not be made. In 3 tumors (trichofolliculoma, pilomatrixoma, and the spectrum fibrofolliculoma/trichodiscoma), there was a parallelism between their Cx43 expression pattern and that of their alleged anatomical counterparts. In pilar sheath acanthoma, trichilemmoma, and the tumor of the follicular infundibulum, we only found partial similarities in Cx43 expression. Only the proliferating trichilemmal tumor showed a discordant pattern of expression. CONCLUSIONS: Cx43 expression is preserved in benign cutaneous tumors with follicular differentiation and the patterns of Cx43 expression in benign cutaneous tumors with follicular differentiation parallel those of their alleged anatomical counterparts in 5 types (either totally or partially). This preservation might be related to the good behavior of the entities studied. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/30839347/Expression_of_Connexin_43_(Cx43)_in_Benign_Cutaneous_Tumors_With_Follicular_Differentiation L2 - http://dx.doi.org/10.1097/DAD.0000000000001395 DB - PRIME DP - Unbound Medicine ER -