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Five years' experience with levonorgestrel-releasing IUDs.
Contraception. 1986 Feb; 33(2):139-48.C

Abstract

Two levonorgestrel-releasing IUDs and a copper-releasing IUD of the same shape were studied in a randomized comparative study over five years. The levonorgestrel-releasing IUDs released 20 micrograms or 30 micrograms per day. The Pearl index during the 10,600 woman-months of LNG-IUD use was 0.11. The control device releasing copper had a Pearl index of 1.6. The amount and duration of menstrual bleeding was greatly reduced, leading to a high incidence of oligo- or amenorrhea. The continuation rate in this pioneer trial was 53 per 100 users for the levonorgestrel-releasing IUD (LNG-IUDs) and 50 per 100 users for the copper-releasing IUD (Nova T). The removal rates for reasons other than amenorrhea were not significantly different. Discontinuation because of amenorrhea occurred during the first two years, the cumulative termination rate for this reason was 11.6 per 100 users at five years. The LNG-IUDs removed for investigation after five years of use revealed that the devices contained about 40 percent of the original load. The effective lifespan of the device has been demonstrated by this study to be five years; the residual steroid gives an additional safety period of two more years. The LNG-IUD is a highly effective reversible contraceptive method, which strongly reduced the amount and duration of bleeding. During the first two months there is scanty but frequent spotting which, like the high incidence of oligo- and/or amenorrhea, requires counselling of health personnel and women using LNG-IUDs.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

3084167

Citation

Luukkainen, T, et al. "Five Years' Experience With Levonorgestrel-releasing IUDs." Contraception, vol. 33, no. 2, 1986, pp. 139-48.
Luukkainen T, Allonen H, Haukkamaa M, et al. Five years' experience with levonorgestrel-releasing IUDs. Contraception. 1986;33(2):139-48.
Luukkainen, T., Allonen, H., Haukkamaa, M., Lähteenmäki, P., Nilsson, C. G., & Toivonen, J. (1986). Five years' experience with levonorgestrel-releasing IUDs. Contraception, 33(2), 139-48.
Luukkainen T, et al. Five Years' Experience With Levonorgestrel-releasing IUDs. Contraception. 1986;33(2):139-48. PubMed PMID: 3084167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five years' experience with levonorgestrel-releasing IUDs. AU - Luukkainen,T, AU - Allonen,H, AU - Haukkamaa,M, AU - Lähteenmäki,P, AU - Nilsson,C G, AU - Toivonen,J, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez KW - Age Distribution KW - Age Factors KW - Biology KW - Comparative Studies KW - Contraception KW - Contraception Termination KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Effectiveness KW - Contraceptive Methods KW - Data Analysis KW - Demographic Analysis KW - Developed Countries KW - Endocrine System KW - Europe KW - Evaluation KW - Examinations And Diagnoses KW - Family Planning KW - Fertility Measurements KW - Finland KW - Hormones KW - Incidence KW - Iud KW - Iud, Copper Releasing KW - Levonorgestrel--administraction and dosage KW - Life Table Method KW - Life Tables KW - Measurement KW - Northern Europe KW - Parity KW - Physical Examinations And Diagnoses KW - Physiology KW - Population KW - Population Characteristics KW - Qualitative Evaluation KW - Reproductive Control Agents KW - Research Methodology KW - Scandinavia KW - Studies KW - Use-effectiveness SP - 139 EP - 48 JF - Contraception JO - Contraception VL - 33 IS - 2 N2 - Two levonorgestrel-releasing IUDs and a copper-releasing IUD of the same shape were studied in a randomized comparative study over five years. The levonorgestrel-releasing IUDs released 20 micrograms or 30 micrograms per day. The Pearl index during the 10,600 woman-months of LNG-IUD use was 0.11. The control device releasing copper had a Pearl index of 1.6. The amount and duration of menstrual bleeding was greatly reduced, leading to a high incidence of oligo- or amenorrhea. The continuation rate in this pioneer trial was 53 per 100 users for the levonorgestrel-releasing IUD (LNG-IUDs) and 50 per 100 users for the copper-releasing IUD (Nova T). The removal rates for reasons other than amenorrhea were not significantly different. Discontinuation because of amenorrhea occurred during the first two years, the cumulative termination rate for this reason was 11.6 per 100 users at five years. The LNG-IUDs removed for investigation after five years of use revealed that the devices contained about 40 percent of the original load. The effective lifespan of the device has been demonstrated by this study to be five years; the residual steroid gives an additional safety period of two more years. The LNG-IUD is a highly effective reversible contraceptive method, which strongly reduced the amount and duration of bleeding. During the first two months there is scanty but frequent spotting which, like the high incidence of oligo- and/or amenorrhea, requires counselling of health personnel and women using LNG-IUDs. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/3084167/Five_years'_experience_with_levonorgestrel_releasing_IUDs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(86)90080-6 DB - PRIME DP - Unbound Medicine ER -