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Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation.
J Toxicol Sci. 2019; 44(3):177-189.JT

Abstract

Recent studies have shown that sevoflurane can cause long-term neurotoxicity and learning and memory impairment in developing and progressively neurodegenerative brains. Sevoflurane is a widely used volatile anesthetic in clinical practice. Late gestation is a rapidly developing period in the fetal brain, but whether sevoflurane anesthesia during late gestation affects learning and memory of offspring is not fully elucidated. Histone deacetylase 2 (HDAC2) plays an important regulatory role in learning and memory. This study examined the effect of maternal sevoflurane exposure on learning and memory in offspring and the underlying role of HDAC2. The Morris water maze (MWM) test was used to evaluate learning and memory function. Q-PCR and immunofluorescence staining were used to measure the expression levels of genes related to learning and memory. The results showed that sevoflurane anesthesia during late gestation impaired learning and memory in offspring rats (e.g., showing increase of the escape latency and decrease of the platform-crossing times and target quadrant traveling time in behavior tests) and upregulated the expression of HDAC2, while downregulating the expression of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the N-methyl-D-aspartate receptor 2 subunit B (NR2B) mRNA and protein in the hippocampus of offspring in a time-dependent manner. HDAC2 inhibitor suberoylanilide hydroxamic acid (SAHA) treatment alleviated all of these changes in offspring rats. Therefore, the present study indicates that sevoflurane exposure during late gestation impairs offspring rat's learning and memory via upregulation of the expression of HDAC2 and downregulation of the expression of CREB and NR2B. SAHA can alleviate these impairments.

Authors+Show Affiliations

Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, Jiangxi Province Traditional Chinese Medicine Hospital, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, China.Department of Anesthesiology, Jiangxi Province Tumor Hospital, China.Department of Immunology, Jiangxi Medical College, Nanchang University, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30842370

Citation

Yu, Qi, et al. "Suberoylanilide Hydroxamic Acid (SAHA) Alleviates the Learning and Memory Impairment in Rat Offspring Caused By Maternal Sevoflurane Exposure During Late Gestation." The Journal of Toxicological Sciences, vol. 44, no. 3, 2019, pp. 177-189.
Yu Q, Feng N, Hu Y, et al. Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation. J Toxicol Sci. 2019;44(3):177-189.
Yu, Q., Feng, N., Hu, Y., Luo, F., Zhao, W., Zhao, W., Liu, Z., Li, M., Xu, L., Wu, L., & Liu, Y. (2019). Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation. The Journal of Toxicological Sciences, 44(3), 177-189. https://doi.org/10.2131/jts.44.177
Yu Q, et al. Suberoylanilide Hydroxamic Acid (SAHA) Alleviates the Learning and Memory Impairment in Rat Offspring Caused By Maternal Sevoflurane Exposure During Late Gestation. J Toxicol Sci. 2019;44(3):177-189. PubMed PMID: 30842370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation. AU - Yu,Qi, AU - Feng,Namin, AU - Hu,Yan, AU - Luo,Foquan, AU - Zhao,Weihong, AU - Zhao,Weilu, AU - Liu,Zhiyi, AU - Li,Mengyuan, AU - Xu,Lin, AU - Wu,Liuqing, AU - Liu,Yulin, PY - 2019/3/8/entrez PY - 2019/3/8/pubmed PY - 2019/3/29/medline KW - Histone deacetylase 2 (HDAC2) KW - Learning and memory KW - Offspring KW - Sevoflurane KW - Suberoylanilide hydroxamic acid (SAHA) KW - Third trimester SP - 177 EP - 189 JF - The Journal of toxicological sciences JO - J Toxicol Sci VL - 44 IS - 3 N2 - Recent studies have shown that sevoflurane can cause long-term neurotoxicity and learning and memory impairment in developing and progressively neurodegenerative brains. Sevoflurane is a widely used volatile anesthetic in clinical practice. Late gestation is a rapidly developing period in the fetal brain, but whether sevoflurane anesthesia during late gestation affects learning and memory of offspring is not fully elucidated. Histone deacetylase 2 (HDAC2) plays an important regulatory role in learning and memory. This study examined the effect of maternal sevoflurane exposure on learning and memory in offspring and the underlying role of HDAC2. The Morris water maze (MWM) test was used to evaluate learning and memory function. Q-PCR and immunofluorescence staining were used to measure the expression levels of genes related to learning and memory. The results showed that sevoflurane anesthesia during late gestation impaired learning and memory in offspring rats (e.g., showing increase of the escape latency and decrease of the platform-crossing times and target quadrant traveling time in behavior tests) and upregulated the expression of HDAC2, while downregulating the expression of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the N-methyl-D-aspartate receptor 2 subunit B (NR2B) mRNA and protein in the hippocampus of offspring in a time-dependent manner. HDAC2 inhibitor suberoylanilide hydroxamic acid (SAHA) treatment alleviated all of these changes in offspring rats. Therefore, the present study indicates that sevoflurane exposure during late gestation impairs offspring rat's learning and memory via upregulation of the expression of HDAC2 and downregulation of the expression of CREB and NR2B. SAHA can alleviate these impairments. SN - 1880-3989 UR - https://www.unboundmedicine.com/medline/citation/30842370/Suberoylanilide_hydroxamic_acid__SAHA__alleviates_the_learning_and_memory_impairment_in_rat_offspring_caused_by_maternal_sevoflurane_exposure_during_late_gestation_ L2 - https://dx.doi.org/10.2131/jts.44.177 DB - PRIME DP - Unbound Medicine ER -