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Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review.
J Clin Lab Anal. 2019 Jun; 33(5):e22876.JC

Abstract

BACKGROUND

Hepatitis C virus (HCV) infection is a global health problem especially for its increasing level of mortality. Detailed knowledge of HCV genotypes prevalence has clinical relevance since the efficacy of therapies is impacted by genotypes and subtypes distribution. Moreover, HCV exhibits a great genetic variability regionally. To date, there are no published studies assessing HCV genotypes distribution in specific countries of the Mediterranean basin. The aim of this study was to review data published from 2000 to 2017 with the purpose to estimate genotypes distribution of HCV infection in nine European countries all located in the Mediterranean basin.

METHODS

A systematic research of peer-reviewed journals indexed in PubMed, Scopus, and EMBASE databases selected if containing data regarding distribution of HCV genotypes in nine selected European countries (Albania, Bosnia, Croatia, France, Greece, Italy, Montenegro, Slovenia, and Spain) was performed.

RESULTS

Genotype 1 is the most common (61.0%), ranging from 80.0% in Croatia to 46.0% in Greece, followed by genotype 3 (20.0%), varying from 38.0% in Slovenia to 7.0% and 8.0%, respectively, in Italy and in Albania and by genotype 4 (10.0%) that shows an increase of 1.1% with respect to data obtained till 2014 probably due to the increasing migrants arrivals to Southern Europe. G2, the fourth most frequent genotype (8.5%), particularly common in Italy (27.0%) and Albania (18.0%) might be probably introduced in Southern Italy as a result of Albanian campaign during Second World War and more and more increased by the migration flows from Albania to Italy in the 90s.

CONCLUSION

Epidemiology of HCV infection shows a high variability across the European countries that border the Mediterranean Sea. HCV genotyping is a relevant tool to monitor the dynamic process influenced by both evolving transmission trends and new migration flows on HCV scenario.

Authors+Show Affiliations

UOC Clinical Pathology, AORN Sant'Anna e San Sebastiano, Caserta, Italy.SSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.SSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.Carol Davila" University of Medicine and Pharmacy, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania.Institute of Biotechnology and Genetic Engineering (Health Davison), The University of Agriculture, Peshawar, Pakistan.Hepatobiliar and Pancreatic Unit, Department of Surgical Oncology, Istituto Nazionale Tumori-Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.Gastroenterology Service, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain.SSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.SSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.SSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.Scientific Director, IRCCS Fondazione Pascale, Naples, Italy.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

30843304

Citation

Petruzziello, Arnolfo, et al. "Prevalence of Hepatitis C Virus Genotypes in Nine Selected European Countries: a Systematic Review." Journal of Clinical Laboratory Analysis, vol. 33, no. 5, 2019, pp. e22876.
Petruzziello A, Loquercio G, Sabatino R, et al. Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review. J Clin Lab Anal. 2019;33(5):e22876.
Petruzziello, A., Loquercio, G., Sabatino, R., Balaban, D. V., Ullah Khan, N., Piccirillo, M., Rodrigo, L., di Capua, L., Guzzo, A., Labonia, F., & Botti, G. (2019). Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review. Journal of Clinical Laboratory Analysis, 33(5), e22876. https://doi.org/10.1002/jcla.22876
Petruzziello A, et al. Prevalence of Hepatitis C Virus Genotypes in Nine Selected European Countries: a Systematic Review. J Clin Lab Anal. 2019;33(5):e22876. PubMed PMID: 30843304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review. AU - Petruzziello,Arnolfo, AU - Loquercio,Giovanna, AU - Sabatino,Rocco, AU - Balaban,Daniel Vasile, AU - Ullah Khan,Najeeb, AU - Piccirillo,Mauro, AU - Rodrigo,Luis, AU - di Capua,Lucia, AU - Guzzo,Annunziata, AU - Labonia,Francesco, AU - Botti,Gerardo, Y1 - 2019/03/07/ PY - 2018/09/24/received PY - 2019/02/08/revised PY - 2019/02/11/accepted PY - 2019/3/8/pubmed PY - 2019/3/8/medline PY - 2019/3/8/entrez KW - HCV genotype KW - HCV infection KW - HCV prevalence KW - Hepatitis C virus KW - epidemiology SP - e22876 EP - e22876 JF - Journal of clinical laboratory analysis JO - J. Clin. Lab. Anal. VL - 33 IS - 5 N2 - BACKGROUND: Hepatitis C virus (HCV) infection is a global health problem especially for its increasing level of mortality. Detailed knowledge of HCV genotypes prevalence has clinical relevance since the efficacy of therapies is impacted by genotypes and subtypes distribution. Moreover, HCV exhibits a great genetic variability regionally. To date, there are no published studies assessing HCV genotypes distribution in specific countries of the Mediterranean basin. The aim of this study was to review data published from 2000 to 2017 with the purpose to estimate genotypes distribution of HCV infection in nine European countries all located in the Mediterranean basin. METHODS: A systematic research of peer-reviewed journals indexed in PubMed, Scopus, and EMBASE databases selected if containing data regarding distribution of HCV genotypes in nine selected European countries (Albania, Bosnia, Croatia, France, Greece, Italy, Montenegro, Slovenia, and Spain) was performed. RESULTS: Genotype 1 is the most common (61.0%), ranging from 80.0% in Croatia to 46.0% in Greece, followed by genotype 3 (20.0%), varying from 38.0% in Slovenia to 7.0% and 8.0%, respectively, in Italy and in Albania and by genotype 4 (10.0%) that shows an increase of 1.1% with respect to data obtained till 2014 probably due to the increasing migrants arrivals to Southern Europe. G2, the fourth most frequent genotype (8.5%), particularly common in Italy (27.0%) and Albania (18.0%) might be probably introduced in Southern Italy as a result of Albanian campaign during Second World War and more and more increased by the migration flows from Albania to Italy in the 90s. CONCLUSION: Epidemiology of HCV infection shows a high variability across the European countries that border the Mediterranean Sea. HCV genotyping is a relevant tool to monitor the dynamic process influenced by both evolving transmission trends and new migration flows on HCV scenario. SN - 1098-2825 UR - https://www.unboundmedicine.com/medline/citation/30843304/Prevalence_of_Hepatitis_C_virus_genotypes_in_nine_selected_European_countries:_A_systematic_review_ L2 - https://doi.org/10.1002/jcla.22876 DB - PRIME DP - Unbound Medicine ER -