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Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis and low vitamin D status.

Abstract

BACKGROUND

Both exogenous vitamin D and selenium reduce thyroid antibody titers. The aim of the study was to investigate whether the impact of vitamin D on thyroid autoimmunity is affected by selenium intake.

METHODS

The study included 47 euthyroid women with Hashimoto's thyroiditis and low vitamin D status, 23 of whom had been treated with selenomethionine (200 μg daily) for at least 12 months before the beginning of the study. During the study, all patients were treated with vitamin D preparations (4000 IU daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as circulating levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D were measured before vitamin D supplementation and 6 months later. Moreover, at the beginning and at the end of the study, we calculated Jostel's thyrotropin index, the SPINA-GT index and the SPINA-GD index.

RESULTS

With the exception of the free triiodothyronine/free thyroxine ratio and the SPINA-GD index, there were no differences between the study groups. In both groups, vitamin D increased 25-hydroxyvitamin D levels, reduced thyroid peroxidase and thyroglobulin antibody titers, as well as increased the SPINA-GT index. The effects on antibody titers and the SPINA-GT index were more pronounced in women receiving selenomethionine. Neither in selenomethionine-treated nor in selenomethionine-naïve women vitamin D affected serum hormone levels, Jostel's index and the SPINA-GD index.

CONCLUSIONS

The results of the study suggest that selenium intake enhances the effect of vitamin D on thyroid autoimmunity.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.

    ,

    Department of Paediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

    Source

    Pharmacological reports : PR 71:2 2019 Apr pg 367-373

    MeSH

    Adult
    Autoantibodies
    Autoantigens
    Autoimmunity
    Female
    Hashimoto Disease
    Humans
    Iodide Peroxidase
    Iron-Binding Proteins
    Middle Aged
    Selenomethionine
    Thyroglobulin
    Thyroid Hormones
    Vitamin D
    Young Adult

    Pub Type(s)

    Comparative Study
    Controlled Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    30844687

    Citation

    Krysiak, Robert, et al. "Selenomethionine Potentiates the Impact of Vitamin D On Thyroid Autoimmunity in Euthyroid Women With Hashimoto's Thyroiditis and Low Vitamin D Status." Pharmacological Reports : PR, vol. 71, no. 2, 2019, pp. 367-373.
    Krysiak R, Kowalcze K, Okopień B. Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis and low vitamin D status. Pharmacol Rep. 2019;71(2):367-373.
    Krysiak, R., Kowalcze, K., & Okopień, B. (2019). Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis and low vitamin D status. Pharmacological Reports : PR, 71(2), pp. 367-373. doi:10.1016/j.pharep.2018.12.006.
    Krysiak R, Kowalcze K, Okopień B. Selenomethionine Potentiates the Impact of Vitamin D On Thyroid Autoimmunity in Euthyroid Women With Hashimoto's Thyroiditis and Low Vitamin D Status. Pharmacol Rep. 2019;71(2):367-373. PubMed PMID: 30844687.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis and low vitamin D status. AU - Krysiak,Robert, AU - Kowalcze,Karolina, AU - Okopień,Bogusław, Y1 - 2018/12/14/ PY - 2018/08/30/received PY - 2018/11/14/revised PY - 2018/12/14/accepted PY - 2019/3/8/pubmed PY - 2019/6/18/medline PY - 2019/3/8/entrez KW - 25-hydroxyvitamin D KW - Selenium KW - Thyroid autoimmunity KW - Vitamin D status SP - 367 EP - 373 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 71 IS - 2 N2 - BACKGROUND: Both exogenous vitamin D and selenium reduce thyroid antibody titers. The aim of the study was to investigate whether the impact of vitamin D on thyroid autoimmunity is affected by selenium intake. METHODS: The study included 47 euthyroid women with Hashimoto's thyroiditis and low vitamin D status, 23 of whom had been treated with selenomethionine (200 μg daily) for at least 12 months before the beginning of the study. During the study, all patients were treated with vitamin D preparations (4000 IU daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as circulating levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D were measured before vitamin D supplementation and 6 months later. Moreover, at the beginning and at the end of the study, we calculated Jostel's thyrotropin index, the SPINA-GT index and the SPINA-GD index. RESULTS: With the exception of the free triiodothyronine/free thyroxine ratio and the SPINA-GD index, there were no differences between the study groups. In both groups, vitamin D increased 25-hydroxyvitamin D levels, reduced thyroid peroxidase and thyroglobulin antibody titers, as well as increased the SPINA-GT index. The effects on antibody titers and the SPINA-GT index were more pronounced in women receiving selenomethionine. Neither in selenomethionine-treated nor in selenomethionine-naïve women vitamin D affected serum hormone levels, Jostel's index and the SPINA-GD index. CONCLUSIONS: The results of the study suggest that selenium intake enhances the effect of vitamin D on thyroid autoimmunity. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/30844687/Selenomethionine_potentiates_the_impact_of_vitamin_D_on_thyroid_autoimmunity_in_euthyroid_women_with_Hashimoto's_thyroiditis_and_low_vitamin_D_status_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(18)30532-2 DB - PRIME DP - Unbound Medicine ER -