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Vaginal microbiome.
Ceska Gynekol. Winter 2018; 83(5):371-379.CG

Abstract

OBJECTIVE

Presentation of complex information about the vaginal microbiota from historical view to current concepts with focus on latest findings on the structure and functioning of the vaginal microbiome.

DESIGN

Review article.

SETTING

Department of Clinical Microbiology, University Hospital and Faculty of Medicine in Hradci Králové, Charles University in Prague.

METHODS

Literature review using the databases (PubMed, Web of Science, Ovid, etc.) with keywords (vaginal microbiota/ microbiom; vaginal discharge; bacterial vaginosis; vulvovaginitis; vaginal Lactobacillus).

RESULTS

The vaginal microbiome is a specific compartment of the human microbiome. Unique conditions of the vagina are characterized by a few microbial species, usually lactobacilli, which are able to utilize glycogen, which is under control of estrogens. Lactobacilli and other fermentative bacteria together with vaginal epithelial cells produce lactic acid and are responsible for acidifying vaginal milieu. Lactic acid occurs in two isomeric forms, and their relative ratio is likely to give the vaginal microbiota a certain degree of stability and ability to withstand some infections. This microbiota is manifested by a low degree of diversity and by the high dynamics of changes of its composition under the influence of various exogenous and endogenous factors. Increase in diversity can be paradoxically associated with a dysbiosis such as bacterial vaginosis. Individual species of lactobacilli mainly Lactobacillus crispatus characterize the main community state types in the vagina. Apart from lactobacilli, healthy women may be colonized with a non-lactobacillary microbiota whose rate is dependent on ethnicity.

CONCLUSION

The definition of vaginal microbiota cannot be only related to the presence or absence of individual microorganisms, although the incidence of some of them can be correlated with dysbiosis or eubiosis. The composition of microbiota is important, but it is only one of the basic attributes of normal vaginal microbiota, but not sufficient; that is the functional definition of vaginal microbiota in relation to its structure and dynamics, including the influence of ethnicity, physiological status of the vagina, and genetic disposition of woman.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30848142

Citation

Buchta, V. "Vaginal Microbiome." Ceska Gynekologie, vol. 83, no. 5, 2018, pp. 371-379.
Buchta V. Vaginal microbiome. Ceska Gynekol. 2018;83(5):371-379.
Buchta, V. (2018). Vaginal microbiome. Ceska Gynekologie, 83(5), 371-379.
Buchta V. Vaginal Microbiome. Ceska Gynekol. Winter 2018;83(5):371-379. PubMed PMID: 30848142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaginal microbiome. A1 - Buchta,V, PY - 2019/3/9/entrez PY - 2018/1/1/pubmed PY - 2019/5/29/medline KW - (vaginal microbiota/ microbiom; vaginal discharge; bacterial vaginosis; vulvovaginitis; vaginal Lactobacillus). Results: The vaginal microbiome is a specific compartment of the human microbiome. Unique conditions of the vagina are characterized by a few microbial species KW - H2O2 KW - Lactobacillus KW - although the incidence of some of them can be correlated with dysbiosis or eubiosis. The composition of microbiota is important KW - and genetic disposition of woman. Keywords: vaginal microbiome KW - and their relative ratio is likely to give the vaginal microbiota a certain degree of stability and ability to withstand some infections. This microbiota is manifested by a low degree of diversity and by the high dynamics of changes of its composition under the influence of various exogenous and endogenous factors. Increase in diversity can be paradoxically associated with a dysbiosis such as bacterial vaginosis. Individual species of lactobacilli mainly Lactobacillus crispatus characterize the main community state types in the vagina. Apart from lactobacilli KW - but it is only one of the basic attributes of normal vaginal microbiota KW - but not sufficient; that is the functional definition of vaginal microbiota in relation to its structure and dynamics KW - community state types KW - dysbiosis KW - healthy women may be colonized with a non-lactobacillary microbiota whose rate is dependent on ethnicity. Conclusion: The definition of vaginal microbiota cannot be only related to the presence or absence of individual microorganisms KW - historical and recent concept KW - including the influence of ethnicity KW - lactic acid KW - pH KW - physiological status of the vagina KW - sexual hormones KW - sexual hormones historical and recent concept. KW - usually lactobacilli KW - vaginal microbiome KW - which are able to utilize glycogen KW - which is under control of estrogens. Lactobacilli and other fermentative bacteria together with vaginal epithelial cells produce lactic acid and are responsible for acidifying vaginal milieu. Lactic acid occurs in two isomeric forms SP - 371 EP - 379 JF - Ceska gynekologie JO - Ceska Gynekol VL - 83 IS - 5 N2 - OBJECTIVE: Presentation of complex information about the vaginal microbiota from historical view to current concepts with focus on latest findings on the structure and functioning of the vaginal microbiome. DESIGN: Review article. SETTING: Department of Clinical Microbiology, University Hospital and Faculty of Medicine in Hradci Králové, Charles University in Prague. METHODS: Literature review using the databases (PubMed, Web of Science, Ovid, etc.) with keywords (vaginal microbiota/ microbiom; vaginal discharge; bacterial vaginosis; vulvovaginitis; vaginal Lactobacillus). RESULTS: The vaginal microbiome is a specific compartment of the human microbiome. Unique conditions of the vagina are characterized by a few microbial species, usually lactobacilli, which are able to utilize glycogen, which is under control of estrogens. Lactobacilli and other fermentative bacteria together with vaginal epithelial cells produce lactic acid and are responsible for acidifying vaginal milieu. Lactic acid occurs in two isomeric forms, and their relative ratio is likely to give the vaginal microbiota a certain degree of stability and ability to withstand some infections. This microbiota is manifested by a low degree of diversity and by the high dynamics of changes of its composition under the influence of various exogenous and endogenous factors. Increase in diversity can be paradoxically associated with a dysbiosis such as bacterial vaginosis. Individual species of lactobacilli mainly Lactobacillus crispatus characterize the main community state types in the vagina. Apart from lactobacilli, healthy women may be colonized with a non-lactobacillary microbiota whose rate is dependent on ethnicity. CONCLUSION: The definition of vaginal microbiota cannot be only related to the presence or absence of individual microorganisms, although the incidence of some of them can be correlated with dysbiosis or eubiosis. The composition of microbiota is important, but it is only one of the basic attributes of normal vaginal microbiota, but not sufficient; that is the functional definition of vaginal microbiota in relation to its structure and dynamics, including the influence of ethnicity, physiological status of the vagina, and genetic disposition of woman. SN - 1210-7832 UR - https://www.unboundmedicine.com/medline/citation/30848142/Vaginal_microbiome_ L2 - https://www.prolekare.cz/linkout/107331 DB - PRIME DP - Unbound Medicine ER -
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