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[Chemotherapy trial in the battle against Schistosoma haematobium in an irrigated sahelian zone in Niger].
Med Trop (Mars). 1986 Jan-Mar; 46(1):21-30.MT

Abstract

This study of S. haematobium infection in communities associated with irrigated schemes shows that prevalence rates are unusually high in adults, especially in men; and distribution disease is probably associated with at least the following three factors: (i) distance of the place of residence from the main transmission sites (ii) the dynamics of transmission in the waterbody and (iii) the human/water contact and contamination patterns. During this chemotherapy trial, at the first survey, only a little more than half (57.47%) of the people recorded in the census was present. Five visits of the survey team were necessary to obtain a compliance rate of 80.51% of the entire population. The indifference of the local people to seek diagnosis and treatment increased with succeeding surveys. It is only, during a subsequent treatment survey, carried out during the season of low agricultural activity and following an official written convocation, that a compliance rate similar to that of the first survey was recorded. If treatment is not given immediately after diagnosis as many as a fifth of positive cases do not appear for treatment. Oltipraz and praziquantel were administered. Their effectiveness could not be truly compared as there was a time lag of six months separating the administration of the treatments. However, based on the results of this trial both drugs gave good results especially in egg output intensity. But, a decrease of this parameter was also observed in non treated people. Seasonal variations of egg output or decrease of transmission could be involved.

Authors

Sellin B
No affiliation info available
Rey JL
No affiliation info available
Simonkovich E
No affiliation info available
Sellin E
No affiliation info available
Mouchet F
No affiliation info available

MeSH

Clinical Trials as TopicDemographyFemaleHumansMaleNigerPatient CompliancePraziquantelPyrazinesSchistosoma haematobiumSchistosomiasis haematobiaSchistosomicidesThionesThiophenesWater MicrobiologyWater Supply

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

3084903

Citation

Sellin, B, et al. "[Chemotherapy Trial in the Battle Against Schistosoma Haematobium in an Irrigated Sahelian Zone in Niger]." Medecine Tropicale : Revue Du Corps De Sante Colonial, vol. 46, no. 1, 1986, pp. 21-30.
Sellin B, Rey JL, Simonkovich E, et al. [Chemotherapy trial in the battle against Schistosoma haematobium in an irrigated sahelian zone in Niger]. Med Trop (Mars). 1986;46(1):21-30.
Sellin, B., Rey, J. L., Simonkovich, E., Sellin, E., & Mouchet, F. (1986). [Chemotherapy trial in the battle against Schistosoma haematobium in an irrigated sahelian zone in Niger]. Medecine Tropicale : Revue Du Corps De Sante Colonial, 46(1), 21-30.
Sellin B, et al. [Chemotherapy Trial in the Battle Against Schistosoma Haematobium in an Irrigated Sahelian Zone in Niger]. Med Trop (Mars). 1986 Jan-Mar;46(1):21-30. PubMed PMID: 3084903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemotherapy trial in the battle against Schistosoma haematobium in an irrigated sahelian zone in Niger]. AU - Sellin,B, AU - Rey,J L, AU - Simonkovich,E, AU - Sellin,E, AU - Mouchet,F, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 21 EP - 30 JF - Medecine tropicale : revue du Corps de sante colonial JO - Med Trop (Mars) VL - 46 IS - 1 N2 - This study of S. haematobium infection in communities associated with irrigated schemes shows that prevalence rates are unusually high in adults, especially in men; and distribution disease is probably associated with at least the following three factors: (i) distance of the place of residence from the main transmission sites (ii) the dynamics of transmission in the waterbody and (iii) the human/water contact and contamination patterns. During this chemotherapy trial, at the first survey, only a little more than half (57.47%) of the people recorded in the census was present. Five visits of the survey team were necessary to obtain a compliance rate of 80.51% of the entire population. The indifference of the local people to seek diagnosis and treatment increased with succeeding surveys. It is only, during a subsequent treatment survey, carried out during the season of low agricultural activity and following an official written convocation, that a compliance rate similar to that of the first survey was recorded. If treatment is not given immediately after diagnosis as many as a fifth of positive cases do not appear for treatment. Oltipraz and praziquantel were administered. Their effectiveness could not be truly compared as there was a time lag of six months separating the administration of the treatments. However, based on the results of this trial both drugs gave good results especially in egg output intensity. But, a decrease of this parameter was also observed in non treated people. Seasonal variations of egg output or decrease of transmission could be involved. SN - 0025-682X UR - https://www.unboundmedicine.com/medline/citation/3084903/[Chemotherapy_trial_in_the_battle_against_Schistosoma_haematobium_in_an_irrigated_sahelian_zone_in_Niger]_ DB - PRIME DP - Unbound Medicine ER -