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Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system.
Neurochem Int. 2019 06; 126:118-125.NI

Abstract

Hydrogen sulfide (H2S) is a signaling molecule used to modify neuronal transmission, regulate vascular tone, protect tissues from oxidative stress, sense oxygen, and generate ATP. Hydrogen polysulfides (H2Sn) have recently been identified as signaling molecules that mediate the activation of ion channels, regulation of tumor growth, and the transcriptional regulation of oxidative stress; some of which were previously ascribed to H2S. Cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) are known as H2S-producing enzymes. 3MST also produces H2Sn and other persulfurated molecules such as cysteine persulfide, glutathione persulfide, and persulfurated proteins. The chemical interaction of H2S and nitric oxide (NO) also produces H2Sn, which may be the mechanism underlying the synergistic effect of H2S and NO that was initially reported on vascular relaxation. H2Sn and other persulfurated molecules elicit their effect via S-sulfuration (S-sulfhydration) of specific cysteine residues of the target proteins. This review article focuses on the production and roles of H2Sn as well as H2S in the central nervous system.

Authors+Show Affiliations

National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan. Electronic address: kimura@ncnp.go.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30849397

Citation

Kimura, Hideo. "Signaling By Hydrogen Sulfide (H2S) and Polysulfides (H2Sn) in the Central Nervous System." Neurochemistry International, vol. 126, 2019, pp. 118-125.
Kimura H. Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system. Neurochem Int. 2019;126:118-125.
Kimura, H. (2019). Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system. Neurochemistry International, 126, 118-125. https://doi.org/10.1016/j.neuint.2019.01.027
Kimura H. Signaling By Hydrogen Sulfide (H2S) and Polysulfides (H2Sn) in the Central Nervous System. Neurochem Int. 2019;126:118-125. PubMed PMID: 30849397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system. A1 - Kimura,Hideo, Y1 - 2019/03/06/ PY - 2019/01/08/received PY - 2019/01/29/revised PY - 2019/01/31/accepted PY - 2019/3/9/pubmed PY - 2019/12/18/medline PY - 2019/3/9/entrez SP - 118 EP - 125 JF - Neurochemistry international JO - Neurochem Int VL - 126 N2 - Hydrogen sulfide (H2S) is a signaling molecule used to modify neuronal transmission, regulate vascular tone, protect tissues from oxidative stress, sense oxygen, and generate ATP. Hydrogen polysulfides (H2Sn) have recently been identified as signaling molecules that mediate the activation of ion channels, regulation of tumor growth, and the transcriptional regulation of oxidative stress; some of which were previously ascribed to H2S. Cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) are known as H2S-producing enzymes. 3MST also produces H2Sn and other persulfurated molecules such as cysteine persulfide, glutathione persulfide, and persulfurated proteins. The chemical interaction of H2S and nitric oxide (NO) also produces H2Sn, which may be the mechanism underlying the synergistic effect of H2S and NO that was initially reported on vascular relaxation. H2Sn and other persulfurated molecules elicit their effect via S-sulfuration (S-sulfhydration) of specific cysteine residues of the target proteins. This review article focuses on the production and roles of H2Sn as well as H2S in the central nervous system. SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/30849397/Signaling_by_hydrogen_sulfide__H2S__and_polysulfides__H2Sn__in_the_central_nervous_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(19)30022-1 DB - PRIME DP - Unbound Medicine ER -