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Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study.
Am J Clin Nutr. 2019 03 01; 109(3):535-543.AJ

Abstract

BACKGROUND

A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia.

OBJECTIVES

We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561).

METHODS

Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass.

RESULTS

Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95% CI) 5-y change in muscle CSA was -9.8 (-10.6, -8.9) cm2. No association was observed between energy-adjusted total (β = -0.00; 95% CI: -0.06, 0.06 cm2; P = 0.982), animal (β = -0.00; 95% CI: -0.06, 0.05 cm2; P = 0.923), or plant (β = +0.07; 95% CI: -0.06, 0.21 cm2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders.

CONCLUSIONS

This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

Authors+Show Affiliations

Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, Netherlands.Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, Netherlands.Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC.Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.California Pacific Medical Center Research Institute, San Francisco, CA. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.Health Science Center, Preventive Medicine, University of Tennessee, Memphis, TN.National Institute on Aging, Bethesda, MD.Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, Netherlands. Nutrition and Dietetics, Department of Internal Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30850837

Citation

Verreijen, Amely M., et al. "Dietary Protein Intake Is Not Associated With 5-y Change in Mid-thigh Muscle Cross-sectional Area By Computed Tomography in Older Adults: the Health, Aging, and Body Composition (Health ABC) Study." The American Journal of Clinical Nutrition, vol. 109, no. 3, 2019, pp. 535-543.
Verreijen AM, Engberink MF, Houston DK, et al. Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2019;109(3):535-543.
Verreijen, A. M., Engberink, M. F., Houston, D. K., Brouwer, I. A., Cawthon, P. M., Newman, A. B., Tylavsky, F. A., Harris, T. B., Weijs, P. J. M., & Visser, M. (2019). Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. The American Journal of Clinical Nutrition, 109(3), 535-543. https://doi.org/10.1093/ajcn/nqy341
Verreijen AM, et al. Dietary Protein Intake Is Not Associated With 5-y Change in Mid-thigh Muscle Cross-sectional Area By Computed Tomography in Older Adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2019 03 1;109(3):535-543. PubMed PMID: 30850837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. AU - Verreijen,Amely M, AU - Engberink,Mariëlle F, AU - Houston,Denise K, AU - Brouwer,Ingeborg A, AU - Cawthon,Peggy M, AU - Newman,Ann B, AU - Tylavsky,Frances A, AU - Harris,Tamara B, AU - Weijs,Peter J M, AU - Visser,Marjolein, PY - 2018/08/09/received PY - 2018/09/06/revised PY - 2018/10/29/accepted PY - 2019/3/10/entrez PY - 2019/3/10/pubmed PY - 2020/1/22/medline KW - age-related muscle loss KW - computed tomography KW - cross-sectional muscle area KW - dietary protein intake KW - older adults SP - 535 EP - 543 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 109 IS - 3 N2 - BACKGROUND: A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia. OBJECTIVES: We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561). METHODS: Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass. RESULTS: Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95% CI) 5-y change in muscle CSA was -9.8 (-10.6, -8.9) cm2. No association was observed between energy-adjusted total (β = -0.00; 95% CI: -0.06, 0.06 cm2; P = 0.982), animal (β = -0.00; 95% CI: -0.06, 0.05 cm2; P = 0.923), or plant (β = +0.07; 95% CI: -0.06, 0.21 cm2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders. CONCLUSIONS: This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/30850837/Dietary_protein_intake_is_not_associated_with_5_y_change_in_mid_thigh_muscle_cross_sectional_area_by_computed_tomography_in_older_adults:_the_Health_Aging_and_Body_Composition__Health_ABC__Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/nqy341 DB - PRIME DP - Unbound Medicine ER -