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Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks.
Fetal Diagn Ther. 2019; 46(6):353-359.FD

Abstract

OBJECTIVE

To evaluate the presence of maxillary gap (MG) and abnormal retronasal triangle (RT) as markers of cleft palate (CP) with and without cleft lip in the first trimester and to assess their association with the type of orofacial cleft (OC).

METHODS

The RT and the mid-sagittal view of the face were evaluated retrospectively by two operators in 26 fetuses with OC and in 80 normal controls to detect abnormal RT and/or MG. The agreement between operators was calculated.

RESULTS

Amongst the 26 fetuses, there were 15 cases of bilateral, 6 cases of unilateral, and 4 cases of median cleft lip and palate, and 1 case of CP alone. The MG was observed in 18 cases by operator 1 and in 17 cases by operator 2; an abnormal RT was detected in 21 cases by operator 1 and in 22 cases by operator 2. Great agreement between operators was obtained. In controls, MG or abnormal RT was suspected in 6 and 2-4% of cases, respectively.

CONCLUSIONS

RT seems to be more sensitive compared to MG; however, the latter showed an additional diagnostic ability when the secondary palate was involved. Both approaches in combination could be useful in detecting OC in the first trimester.

Authors+Show Affiliations

Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy, derobertis_v@libero.it.Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy.Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy.Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy.Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30852571

Citation

De Robertis, Valentina, et al. "Cleft Palate With or Without Cleft Lip: the Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks." Fetal Diagnosis and Therapy, vol. 46, no. 6, 2019, pp. 353-359.
De Robertis V, Rembouskos G, Fanelli T, et al. Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. Fetal Diagn Ther. 2019;46(6):353-359.
De Robertis, V., Rembouskos, G., Fanelli, T., Votino, C., & Volpe, P. (2019). Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. Fetal Diagnosis and Therapy, 46(6), 353-359. https://doi.org/10.1159/000496842
De Robertis V, et al. Cleft Palate With or Without Cleft Lip: the Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. Fetal Diagn Ther. 2019;46(6):353-359. PubMed PMID: 30852571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. AU - De Robertis,Valentina, AU - Rembouskos,Georgios, AU - Fanelli,Tiziana, AU - Votino,Carmela, AU - Volpe,Paolo, Y1 - 2019/03/08/ PY - 2018/08/28/received PY - 2019/01/09/accepted PY - 2019/3/11/pubmed PY - 2020/4/28/medline PY - 2019/3/11/entrez KW - Cleft palate KW - Fetal abnormalities KW - First trimester KW - Nuchal translucency KW - Prenatal diagnosis KW - Prenatal screening SP - 353 EP - 359 JF - Fetal diagnosis and therapy JO - Fetal Diagn Ther VL - 46 IS - 6 N2 - OBJECTIVE: To evaluate the presence of maxillary gap (MG) and abnormal retronasal triangle (RT) as markers of cleft palate (CP) with and without cleft lip in the first trimester and to assess their association with the type of orofacial cleft (OC). METHODS: The RT and the mid-sagittal view of the face were evaluated retrospectively by two operators in 26 fetuses with OC and in 80 normal controls to detect abnormal RT and/or MG. The agreement between operators was calculated. RESULTS: Amongst the 26 fetuses, there were 15 cases of bilateral, 6 cases of unilateral, and 4 cases of median cleft lip and palate, and 1 case of CP alone. The MG was observed in 18 cases by operator 1 and in 17 cases by operator 2; an abnormal RT was detected in 21 cases by operator 1 and in 22 cases by operator 2. Great agreement between operators was obtained. In controls, MG or abnormal RT was suspected in 6 and 2-4% of cases, respectively. CONCLUSIONS: RT seems to be more sensitive compared to MG; however, the latter showed an additional diagnostic ability when the secondary palate was involved. Both approaches in combination could be useful in detecting OC in the first trimester. SN - 1421-9964 UR - https://www.unboundmedicine.com/medline/citation/30852571/Cleft_Palate_with_or_without_Cleft_Lip:_The_Role_of_Retronasal_Triangle_View_and_Maxillary_Gap_at_11_14_Weeks_ L2 - https://www.karger.com?DOI=10.1159/000496842 DB - PRIME DP - Unbound Medicine ER -