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Detection of group a Streptococcus in pharyngitis by two rapid tests: comparison of the BD Veritor™ and the QuikRead go® Strep A.
Eur J Clin Microbiol Infect Dis 2019; 38(6):1179-1185EJ

Abstract

We compared the performance of two rapid antigen tests-QuikRead go® Strep A test (Orion Diagnostica, Espoo, Finland) and BD Veritor™ system (Becton, Dickinson and Company, Sparks, MD) with throat culture. Our aim was to evaluate each assay's performance and agreement compared to throat culture in order to choose one of the assays as a point-of-care test in the emergency room. One hundred throat samples were collected in triplicates from patients with suspected pharyngitis admitted to the emergency room. One throat swab was seeded for a throat culture. The other two throat swabs from each patient were analyzed at the emergency room by the QuikRead go® Strep A test, and by the BD Veritor™ system, according to each manufacturer's instructions. Agreement level between BD Veritor™ test and throat culture was 79%; sensitivity and specificity of this test were 80% and 78.7%, respectively. QuikRead go® Strep A test had an agreement level of 75% with throat culture; sensitivity and specificity of this test were 80% and 73.3%, respectively. Both tests have a good diagnostic performance. Other characteristics such as costs, size of instrument, and ease of implementation should be taken into consideration when choosing a point-of-care test.

Authors+Show Affiliations

Clinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, Israel.The Otolaryngology, Head and Neck Surgery Unit, The Baruch Padeh Medical Center, Poriya, Tiberias, Israel.The Otolaryngology, Head and Neck Surgery Unit, The Baruch Padeh Medical Center, Poriya, Tiberias, Israel. The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. Infectious Disease Unit, Poriya Medical Center, Poriya, Tiberias, Israel.Clinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, Israel. aperetz@poria.health.gov.il. The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. aperetz@poria.health.gov.il.

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article

Language

eng

PubMed ID

30852698

Citation

Azrad, Maya, et al. "Detection of Group a Streptococcus in Pharyngitis By Two Rapid Tests: Comparison of the BD Veritor™ and the QuikRead Go® Strep A." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 38, no. 6, 2019, pp. 1179-1185.
Azrad M, Danilov E, Goshen S, et al. Detection of group a Streptococcus in pharyngitis by two rapid tests: comparison of the BD Veritor™ and the QuikRead go® Strep A. Eur J Clin Microbiol Infect Dis. 2019;38(6):1179-1185.
Azrad, M., Danilov, E., Goshen, S., Nitzan, O., & Peretz, A. (2019). Detection of group a Streptococcus in pharyngitis by two rapid tests: comparison of the BD Veritor™ and the QuikRead go® Strep A. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 38(6), pp. 1179-1185. doi:10.1007/s10096-019-03527-w.
Azrad M, et al. Detection of Group a Streptococcus in Pharyngitis By Two Rapid Tests: Comparison of the BD Veritor™ and the QuikRead Go® Strep A. Eur J Clin Microbiol Infect Dis. 2019;38(6):1179-1185. PubMed PMID: 30852698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of group a Streptococcus in pharyngitis by two rapid tests: comparison of the BD Veritor™ and the QuikRead go® Strep A. AU - Azrad,Maya, AU - Danilov,Elena, AU - Goshen,Sivan, AU - Nitzan,Orna, AU - Peretz,Avi, Y1 - 2019/03/09/ PY - 2019/01/07/received PY - 2019/02/28/accepted PY - 2019/3/11/pubmed PY - 2019/3/11/medline PY - 2019/3/11/entrez KW - Antibiotic treatment KW - Group A Streptococcus KW - Pharyngitis KW - Rapid tests SP - 1179 EP - 1185 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur. J. Clin. Microbiol. Infect. Dis. VL - 38 IS - 6 N2 - We compared the performance of two rapid antigen tests-QuikRead go® Strep A test (Orion Diagnostica, Espoo, Finland) and BD Veritor™ system (Becton, Dickinson and Company, Sparks, MD) with throat culture. Our aim was to evaluate each assay's performance and agreement compared to throat culture in order to choose one of the assays as a point-of-care test in the emergency room. One hundred throat samples were collected in triplicates from patients with suspected pharyngitis admitted to the emergency room. One throat swab was seeded for a throat culture. The other two throat swabs from each patient were analyzed at the emergency room by the QuikRead go® Strep A test, and by the BD Veritor™ system, according to each manufacturer's instructions. Agreement level between BD Veritor™ test and throat culture was 79%; sensitivity and specificity of this test were 80% and 78.7%, respectively. QuikRead go® Strep A test had an agreement level of 75% with throat culture; sensitivity and specificity of this test were 80% and 73.3%, respectively. Both tests have a good diagnostic performance. Other characteristics such as costs, size of instrument, and ease of implementation should be taken into consideration when choosing a point-of-care test. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/30852698/Detection_of_group_a_Streptococcus_in_pharyngitis_by_two_rapid_tests:_comparison_of_the_BD_Veritor™_and_the_QuikRead_go®_Strep_A L2 - https://dx.doi.org/10.1007/s10096-019-03527-w DB - PRIME DP - Unbound Medicine ER -