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Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study.
Br J Nutr. 2019 06; 121(11):1223-1234.BJ

Abstract

Studies have shown that the reduction in serum TAG concentrations with long-chain n-3 fatty acid supplementation is highly variable among individuals. The objectives of the present study were to compare the proportions of individuals whose TAG concentrations lowered after high-dose DHA and EPA, and to identify the predictors of response to both modalities. In a double-blind, controlled, crossover study, 154 men and women were randomised to three supplemented phases of 10 weeks each: (1) 2·7 g/d of DHA, (2) 2·7 g/d of EPA and (3) 3 g/d of maize oil, separated by 9-week washouts. As secondary analyses, the mean intra-individual variation in TAG was calculated using the standard deviation from the mean of four off-treatment samples. The response remained within the intra-individual variation (±0·25 mmol/l) in 47 and 57 % of participants after DHA and EPA, respectively. Although there was a greater proportion of participants with a reduction >0·25 mmol/l after DHA than after EPA (45 υ. 32 %; P 0·25 mmol/l after both DHA and EPA had higher non-HDL-cholesterol, TAG and insulin concentrations compared with other responders at baseline (all P < 0·05). In conclusion, supplementation with 2·7 g/d DHA or EPA had no meaningful effect on TAG concentrations in a large proportion of individuals with normal mean TAG concentrations at baseline. Although DHA lowered TAG in a greater proportion of individuals compared with EPA, the magnitude of TAG lowering among them was similar.

Authors+Show Affiliations

Institut sur la nutrition et les aliments fonctionnels (INAF), Pavillon des Services,Université Laval,Québec,Canada.Institut sur la nutrition et les aliments fonctionnels (INAF), Pavillon des Services,Université Laval,Québec,Canada.Sanford School of Medicine,The University of South Dakota,Sioux Falls, SD,USA.OmegaQuant Analytics,LLC,Sioux Falls, SD,USA.Institut sur la nutrition et les aliments fonctionnels (INAF), Pavillon des Services,Université Laval,Québec,Canada.Institut sur la nutrition et les aliments fonctionnels (INAF), Pavillon des Services,Université Laval,Québec,Canada.Institut sur la nutrition et les aliments fonctionnels (INAF), Pavillon des Services,Université Laval,Québec,Canada.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30854986

Citation

Allaire, Janie, et al. "Comparing the Serum TAG Response to High-dose Supplementation of Either DHA or EPA Among Individuals With Increased Cardiovascular Risk: the ComparED Study." The British Journal of Nutrition, vol. 121, no. 11, 2019, pp. 1223-1234.
Allaire J, Vors C, Harris WS, et al. Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study. Br J Nutr. 2019;121(11):1223-1234.
Allaire, J., Vors, C., Harris, W. S., Jackson, K. H., Tchernof, A., Couture, P., & Lamarche, B. (2019). Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study. The British Journal of Nutrition, 121(11), 1223-1234. https://doi.org/10.1017/S0007114519000552
Allaire J, et al. Comparing the Serum TAG Response to High-dose Supplementation of Either DHA or EPA Among Individuals With Increased Cardiovascular Risk: the ComparED Study. Br J Nutr. 2019;121(11):1223-1234. PubMed PMID: 30854986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study. AU - Allaire,Janie, AU - Vors,Cécile, AU - Harris,William S, AU - Jackson,Kristina Harris, AU - Tchernof,André, AU - Couture,Patrick, AU - Lamarche,Benoît, Y1 - 2019/03/11/ PY - 2019/3/12/pubmed PY - 2020/5/8/medline PY - 2019/3/12/entrez KW - Apo B total apo B100 KW - CRP C-reactive protein KW - FADS1 fatty acid desaturase 1 or delta-5 fatty acid desaturase KW - FADS2 fatty acid desaturase 2 or delta-6 fatty acid desaturase KW - GAPDH glyceraldehyde 3-phosphate dehydrogenase KW - HDL-C HDL-cholesterol KW - HMG-CoA reductase 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase KW - LCn3-PUFA long-chain n-3 PUFA KW - LDL-C LDL-cholesterol KW - LDL-R LDL receptor KW - PCSK9 proprotein convertase subtilisin/kexin type 9 KW - REDUCE-IT Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial KW - SREBP sterol regulatory element-binding protein KW - DHA KW - EPA KW - Intra-individual variations KW - TAG KW - Variability SP - 1223 EP - 1234 JF - The British journal of nutrition JO - Br J Nutr VL - 121 IS - 11 N2 - Studies have shown that the reduction in serum TAG concentrations with long-chain n-3 fatty acid supplementation is highly variable among individuals. The objectives of the present study were to compare the proportions of individuals whose TAG concentrations lowered after high-dose DHA and EPA, and to identify the predictors of response to both modalities. In a double-blind, controlled, crossover study, 154 men and women were randomised to three supplemented phases of 10 weeks each: (1) 2·7 g/d of DHA, (2) 2·7 g/d of EPA and (3) 3 g/d of maize oil, separated by 9-week washouts. As secondary analyses, the mean intra-individual variation in TAG was calculated using the standard deviation from the mean of four off-treatment samples. The response remained within the intra-individual variation (±0·25 mmol/l) in 47 and 57 % of participants after DHA and EPA, respectively. Although there was a greater proportion of participants with a reduction >0·25 mmol/l after DHA than after EPA (45 υ. 32 %; P 0·25 mmol/l after both DHA and EPA had higher non-HDL-cholesterol, TAG and insulin concentrations compared with other responders at baseline (all P < 0·05). In conclusion, supplementation with 2·7 g/d DHA or EPA had no meaningful effect on TAG concentrations in a large proportion of individuals with normal mean TAG concentrations at baseline. Although DHA lowered TAG in a greater proportion of individuals compared with EPA, the magnitude of TAG lowering among them was similar. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/30854986/Comparing_the_serum_TAG_response_to_high_dose_supplementation_of_either_DHA_or_EPA_among_individuals_with_increased_cardiovascular_risk:_the_ComparED_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114519000552/type/journal_article DB - PRIME DP - Unbound Medicine ER -