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CdTe QD-CeO2 Complex as a Strong Photoelectrochemical Signal Indicator for the Ultrasensitive microRNA Assay.
ACS Appl Mater Interfaces. 2019 Mar 27; 11(12):11834-11840.AA

Abstract

The photoelectrochemical (PEC) signal can be enhanced by constructing sensitization structures containing photoactive materials and appropriate sensitizers. However, usually, the photoactive materials and sensitizers were separated in independent nanostructures, thereby producing long electron-transfer path and large energy loss, which could further result in limited photoelectric conversion efficiency and PEC signals. Herein, we designed a novel sensitization nanostructure simultaneously containing the photoactive material cerium dioxide (CeO2) and its sensitizer CdTe quantum dots (QDs) as the strong PEC signal indicator (CdTe QD-CeO2 complex), which prominently enhanced photoelectric conversion efficiency because of the shortened electron-transfer path and reduced energy loss. The proposed CdTe QD-CeO2 complex was used to construct a PEC biosensor for achieving ultrasensitive determination of microRNA-141 (miRNA-141) coupling with target converting amplification and DNA supersandwich structure amplification. The designed PEC biosensor demonstrated a wide linear range from 0.5 fM to 5 nM with a detection limit of 0.17 fM for miRNA-141. Impressively, this work provided a new and strong PEC signal indicator for the construction of PEC sensing platform and would extend the application of PEC sensors in bioanalysis and early disease diagnosis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li M
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China.
Liang W
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China.
Yuan R
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China.
Chai Y
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China.

MeSH

Biosensing TechniquesCadmium CompoundsCeriumElectrochemical TechniquesElectrodesFerrosoferric OxideGoldHumansLimit of DetectionMicroRNAsNanostructuresQuantum DotsTellurium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30855130

Citation

Li, Mengjie, et al. "CdTe QD-CeO2 Complex as a Strong Photoelectrochemical Signal Indicator for the Ultrasensitive microRNA Assay." ACS Applied Materials & Interfaces, vol. 11, no. 12, 2019, pp. 11834-11840.
Li M, Liang W, Yuan R, et al. CdTe QD-CeO2 Complex as a Strong Photoelectrochemical Signal Indicator for the Ultrasensitive microRNA Assay. ACS Appl Mater Interfaces. 2019;11(12):11834-11840.
Li, M., Liang, W., Yuan, R., & Chai, Y. (2019). CdTe QD-CeO2 Complex as a Strong Photoelectrochemical Signal Indicator for the Ultrasensitive microRNA Assay. ACS Applied Materials & Interfaces, 11(12), 11834-11840. https://doi.org/10.1021/acsami.9b02189
Li M, et al. CdTe QD-CeO2 Complex as a Strong Photoelectrochemical Signal Indicator for the Ultrasensitive microRNA Assay. ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11834-11840. PubMed PMID: 30855130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CdTe QD-CeO2 Complex as a Strong Photoelectrochemical Signal Indicator for the Ultrasensitive microRNA Assay. AU - Li,Mengjie, AU - Liang,Wenbin, AU - Yuan,Ruo, AU - Chai,Yaqin, Y1 - 2019/03/19/ PY - 2019/3/12/pubmed PY - 2019/7/13/medline PY - 2019/3/12/entrez KW - CdTe QD−CeO2 complex KW - dual signal amplification KW - microRNA assay KW - photoelectrochemical sensing KW - signal indicator SP - 11834 EP - 11840 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 11 IS - 12 N2 - The photoelectrochemical (PEC) signal can be enhanced by constructing sensitization structures containing photoactive materials and appropriate sensitizers. However, usually, the photoactive materials and sensitizers were separated in independent nanostructures, thereby producing long electron-transfer path and large energy loss, which could further result in limited photoelectric conversion efficiency and PEC signals. Herein, we designed a novel sensitization nanostructure simultaneously containing the photoactive material cerium dioxide (CeO2) and its sensitizer CdTe quantum dots (QDs) as the strong PEC signal indicator (CdTe QD-CeO2 complex), which prominently enhanced photoelectric conversion efficiency because of the shortened electron-transfer path and reduced energy loss. The proposed CdTe QD-CeO2 complex was used to construct a PEC biosensor for achieving ultrasensitive determination of microRNA-141 (miRNA-141) coupling with target converting amplification and DNA supersandwich structure amplification. The designed PEC biosensor demonstrated a wide linear range from 0.5 fM to 5 nM with a detection limit of 0.17 fM for miRNA-141. Impressively, this work provided a new and strong PEC signal indicator for the construction of PEC sensing platform and would extend the application of PEC sensors in bioanalysis and early disease diagnosis. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/30855130/CdTe_QD_CeO2_Complex_as_a_Strong_Photoelectrochemical_Signal_Indicator_for_the_Ultrasensitive_microRNA_Assay_ L2 - https://doi.org/10.1021/acsami.9b02189 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓2]

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