Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group.Org Lett. 2019 04 05; 21(7):2085-2089.OL
Abstract
This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino- N-isopropylpropionamide was more beneficial to the β-arylation of aliphatic aldehydes than other TDGs under relatively mild conditions.
Links
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
30859828
Citation
Dong, Cong, et al. "Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group." Organic Letters, vol. 21, no. 7, 2019, pp. 2085-2089.
Dong C, Wu L, Yao J, et al. Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group. Org Lett. 2019;21(7):2085-2089.
Dong, C., Wu, L., Yao, J., & Wei, K. (2019). Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group. Organic Letters, 21(7), 2085-2089. https://doi.org/10.1021/acs.orglett.9b00366
Dong C, et al. Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group. Org Lett. 2019 04 5;21(7):2085-2089. PubMed PMID: 30859828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group.
AU - Dong,Cong,
AU - Wu,Liangfei,
AU - Yao,Jianwei,
AU - Wei,Kun,
Y1 - 2019/03/12/
PY - 2019/3/13/pubmed
PY - 2019/3/13/medline
PY - 2019/3/13/entrez
SP - 2085
EP - 2089
JF - Organic letters
JO - Org Lett
VL - 21
IS - 7
N2 - This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino- N-isopropylpropionamide was more beneficial to the β-arylation of aliphatic aldehydes than other TDGs under relatively mild conditions.
SN - 1523-7052
UR - https://www.unboundmedicine.com/medline/citation/30859828/Palladium_Catalyzed_β_C_H_Arylation_of_Aliphatic_Aldehydes_and_Ketones_Using_Amino_Amide_as_a_Transient_Directing_Group_
L2 - https://doi.org/10.1021/acs.orglett.9b00366
DB - PRIME
DP - Unbound Medicine
ER -
