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Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis.
Z Gastroenterol 2019; 57(3):312-316ZG

Abstract

The relevance of gastrointestinal manifestations of cystic fibrosis (CF) is increasing due to an improved life expectancy. We report on 2 adult patients with prior lung transplantation who presented with a severe inflammatory disorder of the ileocecal region. One patient underwent ileocecal resection; the second patient died after emergency surgery for intestinal perforation. Both cases did not show typical signs of CF-related distal intestinal obstruction syndrome or extensive fibrosing colonopathy. However, the clinical and histopathological findings revealed CF-induced inflammatory alterations of the intestinal mucosa. Thus, these cases illustrate a further CF-related bowel disorder, which can be especially relevant in long-term CF survivors.

Authors+Show Affiliations

University Hospital Leipzig, Division of Gastroenterology, Leipzig, Germany.University Hospital Leipzig, Division of Pulmonology, Leipzig, Germany.University Hospital Leipzig, Division of Pulmonology, Leipzig, Germany.University Hospital Leipzig, Division of Gastroenterology, Leipzig, Germany.University Hospital Leipzig, Institute of Pathology, Leipzig, Germany.University Hospital Leipzig, Division of Gastroenterology, Leipzig, Germany.University Hospital Leipzig, Division of Pulmonology, Leipzig, Germany.University Hospital Leipzig, Division of Gastroenterology, Leipzig, Germany.University Hospital Leipzig, Department of Visceral, Transplant, Thoracic and Vascular Surgery, Leipzig, Germany.University Hospital Leipzig, Division of Gastroenterology, Leipzig, Germany.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30861555

Citation

Henker, Robert, et al. "Severe Ileocecal Inflammatory Syndrome in Adult Patients With Cystic Fibrosis." Zeitschrift Fur Gastroenterologie, vol. 57, no. 3, 2019, pp. 312-316.
Henker R, Oltmanns A, Wald A, et al. Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis. Z Gastroenterol. 2019;57(3):312-316.
Henker, R., Oltmanns, A., Wald, A., Tuennemann, J., Opitz, S., Hoffmeister, A., ... Karlas, T. (2019). Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis. Zeitschrift Fur Gastroenterologie, 57(3), pp. 312-316. doi:10.1055/a-0829-7050.
Henker R, et al. Severe Ileocecal Inflammatory Syndrome in Adult Patients With Cystic Fibrosis. Z Gastroenterol. 2019;57(3):312-316. PubMed PMID: 30861555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis. AU - Henker,Robert, AU - Oltmanns,Annett, AU - Wald,Alexandra, AU - Tuennemann,Jan, AU - Opitz,Sabine, AU - Hoffmeister,Albrecht, AU - Wirtz,Hubert, AU - Mössner,Joachim, AU - Jansen-Winkeln,Boris, AU - Karlas,Thomas, Y1 - 2019/03/12/ PY - 2019/3/13/entrez PY - 2019/3/13/pubmed PY - 2019/8/30/medline SP - 312 EP - 316 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 57 IS - 3 N2 - The relevance of gastrointestinal manifestations of cystic fibrosis (CF) is increasing due to an improved life expectancy. We report on 2 adult patients with prior lung transplantation who presented with a severe inflammatory disorder of the ileocecal region. One patient underwent ileocecal resection; the second patient died after emergency surgery for intestinal perforation. Both cases did not show typical signs of CF-related distal intestinal obstruction syndrome or extensive fibrosing colonopathy. However, the clinical and histopathological findings revealed CF-induced inflammatory alterations of the intestinal mucosa. Thus, these cases illustrate a further CF-related bowel disorder, which can be especially relevant in long-term CF survivors. SN - 1439-7803 UR - https://www.unboundmedicine.com/medline/citation/30861555/Severe_ileocecal_inflammatory_syndrome_in_adult_patients_with_cystic_fibrosis L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0829-7050 DB - PRIME DP - Unbound Medicine ER -