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Combined effect of conventional antimicrobials with essential oils and their main components against resistant Streptococcus suis strains.
Lett Appl Microbiol. 2019 Jun; 68(6):562-572.LA

Abstract

Streptococcus suis is a major swine pathogen. Different strategies to reduce the antimicrobial resistance to conventional antimicrobials (AMBs) have been proposed, including the combined use with essential oils (EOs). The objective of this work was to evaluate the effectiveness of the combination of cinnamon, oregano, common thyme and red thyme EOs and their main components (cinnamaldehyde, carvacrol and thymol) with conventional AMBs (oxytetracycline, trimethoprim-sulfamethoxazole, gentamicin and penicillin) against field resistant S. suis strains. The checkerboard method was used to assess the interaction, by the fractional inhibitory concentration index (FICindex) determination. All the AMBs showed synergistic (FICindex ≤ 0·5) or additive (0·5 < FICindex ≤ 1) effect with at least one of the four essential oils. In general, the combination of the AMBs with the EOs showed better results than combination the AMBs with the main components, although no antagonist effects were detected in any case. The results obtained would support the combined use of AMBs agents with EOs for the treatment of S. suis. SIGNIFICANCE AND IMPACT OF THE STUDY: Streptococcus suis is an important pig pathogen and a zoonosis. Control is based on antimicrobials; however, there is pressure to reduce the use of antimicrobials and new products or combination therapies are of considerable interest. We have evaluated the combined interaction of four essential oils or their main components with conventional antimicrobials against resistant S. suis strains. A positive interaction between gentamicin and oxytetracycline with cinnamon, oregano or thyme was observed, suggesting that a combination of conventional antimicrobials with EOs is a promising alternative for the control of S. suis infections.

Authors+Show Affiliations

Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain.Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain. Medicine Faculty, University Cooperative of Colombia, Pasto, Colombia.Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain.Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain.Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain.Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain.Departamento de Sanidad Animal, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Córdoba, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30861569

Citation

de Aguiar, F C., et al. "Combined Effect of Conventional Antimicrobials With Essential Oils and Their Main Components Against Resistant Streptococcus Suis Strains." Letters in Applied Microbiology, vol. 68, no. 6, 2019, pp. 562-572.
de Aguiar FC, Solarte AL, Tarradas C, et al. Combined effect of conventional antimicrobials with essential oils and their main components against resistant Streptococcus suis strains. Lett Appl Microbiol. 2019;68(6):562-572.
de Aguiar, F. C., Solarte, A. L., Tarradas, C., Gómez-Gascón, L., Astorga, R., Maldonado, A., & Huerta, B. (2019). Combined effect of conventional antimicrobials with essential oils and their main components against resistant Streptococcus suis strains. Letters in Applied Microbiology, 68(6), 562-572. https://doi.org/10.1111/lam.13151
de Aguiar FC, et al. Combined Effect of Conventional Antimicrobials With Essential Oils and Their Main Components Against Resistant Streptococcus Suis Strains. Lett Appl Microbiol. 2019;68(6):562-572. PubMed PMID: 30861569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effect of conventional antimicrobials with essential oils and their main components against resistant Streptococcus suis strains. AU - de Aguiar,F C, AU - Solarte,A L, AU - Tarradas,C, AU - Gómez-Gascón,L, AU - Astorga,R, AU - Maldonado,A, AU - Huerta,B, Y1 - 2019/04/25/ PY - 2018/12/14/received PY - 2019/03/07/revised PY - 2019/03/07/accepted PY - 2019/3/13/pubmed PY - 2019/7/2/medline PY - 2019/3/13/entrez KW - Streptococcus suis KW - antimicrobial interactions KW - conventional antimicrobials KW - essential oils KW - main components SP - 562 EP - 572 JF - Letters in applied microbiology JO - Lett Appl Microbiol VL - 68 IS - 6 N2 - Streptococcus suis is a major swine pathogen. Different strategies to reduce the antimicrobial resistance to conventional antimicrobials (AMBs) have been proposed, including the combined use with essential oils (EOs). The objective of this work was to evaluate the effectiveness of the combination of cinnamon, oregano, common thyme and red thyme EOs and their main components (cinnamaldehyde, carvacrol and thymol) with conventional AMBs (oxytetracycline, trimethoprim-sulfamethoxazole, gentamicin and penicillin) against field resistant S. suis strains. The checkerboard method was used to assess the interaction, by the fractional inhibitory concentration index (FICindex) determination. All the AMBs showed synergistic (FICindex ≤ 0·5) or additive (0·5 < FICindex ≤ 1) effect with at least one of the four essential oils. In general, the combination of the AMBs with the EOs showed better results than combination the AMBs with the main components, although no antagonist effects were detected in any case. The results obtained would support the combined use of AMBs agents with EOs for the treatment of S. suis. SIGNIFICANCE AND IMPACT OF THE STUDY: Streptococcus suis is an important pig pathogen and a zoonosis. Control is based on antimicrobials; however, there is pressure to reduce the use of antimicrobials and new products or combination therapies are of considerable interest. We have evaluated the combined interaction of four essential oils or their main components with conventional antimicrobials against resistant S. suis strains. A positive interaction between gentamicin and oxytetracycline with cinnamon, oregano or thyme was observed, suggesting that a combination of conventional antimicrobials with EOs is a promising alternative for the control of S. suis infections. SN - 1472-765X UR - https://www.unboundmedicine.com/medline/citation/30861569/Combined_effect_of_conventional_antimicrobials_with_essential_oils_and_their_main_components_against_resistant_Streptococcus_suis_strains_ DB - PRIME DP - Unbound Medicine ER -