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Dose finding of tocainide in the treatment of tinnitus.
Int J Clin Pharmacol Ther Toxicol. 1986 Apr; 24(4):207-12.IJ

Abstract

A dose finding study was performed for the use of oral tocainide in the treatment of tinnitus. In a single-blind study, increasing doses of tocainide hydrochloride ranging from 0 to 1800 mg and back to 0 mg were administered to 19 patients. Each dose was given for 4 days and the effects as well as the serum concentrations were recorded on the 4th day. In 8 patients the symptoms regressed to a non-troublesome level. In most instances this effect was seen at doses of 900 and 1800 mg, respectively. Side effects were frequent. The most important side effect, which was an absolute indication for termination of the study, was an exanthema that developed in 7 of the patients (37%). Taking into account all side effects observed, it was concluded that no justification exists for doses over 900 mg daily for the treatment of tinnitus. However, in comparison with lidocaine, which can only be given intravenously, the therapeutic score of tocainide is low and in fact tocainide is no satisfactory alternative to lidocaine.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3086242

Citation

Vermeij, P, and J H. Hulshof. "Dose Finding of Tocainide in the Treatment of Tinnitus." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 24, no. 4, 1986, pp. 207-12.
Vermeij P, Hulshof JH. Dose finding of tocainide in the treatment of tinnitus. Int J Clin Pharmacol Ther Toxicol. 1986;24(4):207-12.
Vermeij, P., & Hulshof, J. H. (1986). Dose finding of tocainide in the treatment of tinnitus. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 24(4), 207-12.
Vermeij P, Hulshof JH. Dose Finding of Tocainide in the Treatment of Tinnitus. Int J Clin Pharmacol Ther Toxicol. 1986;24(4):207-12. PubMed PMID: 3086242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose finding of tocainide in the treatment of tinnitus. AU - Vermeij,P, AU - Hulshof,J H, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 207 EP - 12 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 24 IS - 4 N2 - A dose finding study was performed for the use of oral tocainide in the treatment of tinnitus. In a single-blind study, increasing doses of tocainide hydrochloride ranging from 0 to 1800 mg and back to 0 mg were administered to 19 patients. Each dose was given for 4 days and the effects as well as the serum concentrations were recorded on the 4th day. In 8 patients the symptoms regressed to a non-troublesome level. In most instances this effect was seen at doses of 900 and 1800 mg, respectively. Side effects were frequent. The most important side effect, which was an absolute indication for termination of the study, was an exanthema that developed in 7 of the patients (37%). Taking into account all side effects observed, it was concluded that no justification exists for doses over 900 mg daily for the treatment of tinnitus. However, in comparison with lidocaine, which can only be given intravenously, the therapeutic score of tocainide is low and in fact tocainide is no satisfactory alternative to lidocaine. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/3086242/Dose_finding_of_tocainide_in_the_treatment_of_tinnitus_ L2 - http://www.diseaseinfosearch.org/result/9653 DB - PRIME DP - Unbound Medicine ER -