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Current understanding of the role of gut dysbiosis in type 1 diabetes.
J Diabetes. 2019 Aug; 11(8):632-644.JD

Abstract

Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin-producing pancreatic β-cells. The disease mainly affects juveniles. Changes in the composition of the gut microbiota (dysbiosis) and changes in the properties of the gut barrier have been documented in T1D subjects. Because these factors affect immune system functions, they are likely to play a role in disease pathogenesis. However, their exact role is currently not fully understood and is under intensive investigation. In this article we discuss recent advancements depicting the role of intestinal dysbiosis on immunity and autoimmunity in T1D. We also discuss therapies aimed at maintaining a healthy gut barrier as prevention strategies for T1D.

Authors+Show Affiliations

Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, Nebraska. Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska. Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, Nebraska. Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30864231

Citation

Abdellatif, Ahmed M., and Nora E. Sarvetnick. "Current Understanding of the Role of Gut Dysbiosis in Type 1 Diabetes." Journal of Diabetes, vol. 11, no. 8, 2019, pp. 632-644.
Abdellatif AM, Sarvetnick NE. Current understanding of the role of gut dysbiosis in type 1 diabetes. J Diabetes. 2019;11(8):632-644.
Abdellatif, A. M., & Sarvetnick, N. E. (2019). Current understanding of the role of gut dysbiosis in type 1 diabetes. Journal of Diabetes, 11(8), 632-644. https://doi.org/10.1111/1753-0407.12915
Abdellatif AM, Sarvetnick NE. Current Understanding of the Role of Gut Dysbiosis in Type 1 Diabetes. J Diabetes. 2019;11(8):632-644. PubMed PMID: 30864231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current understanding of the role of gut dysbiosis in type 1 diabetes. AU - Abdellatif,Ahmed M, AU - Sarvetnick,Nora E, Y1 - 2019/04/22/ PY - 2018/09/14/received PY - 2019/02/13/revised PY - 2019/03/11/accepted PY - 2019/3/14/pubmed PY - 2019/3/14/medline PY - 2019/3/14/entrez KW - 1型糖尿病 KW - autoimmunity KW - dysbiosis KW - gut barrier KW - microbiome KW - type 1 diabetes KW - 微生物群 KW - 肠道屏障 KW - 自身免疫 KW - 菌群失调 SP - 632 EP - 644 JF - Journal of diabetes JO - J Diabetes VL - 11 IS - 8 N2 - Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin-producing pancreatic β-cells. The disease mainly affects juveniles. Changes in the composition of the gut microbiota (dysbiosis) and changes in the properties of the gut barrier have been documented in T1D subjects. Because these factors affect immune system functions, they are likely to play a role in disease pathogenesis. However, their exact role is currently not fully understood and is under intensive investigation. In this article we discuss recent advancements depicting the role of intestinal dysbiosis on immunity and autoimmunity in T1D. We also discuss therapies aimed at maintaining a healthy gut barrier as prevention strategies for T1D. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/30864231/Current_understanding_of_the_role_of_gut_dysbiosis_in_type_1_diabetes_ L2 - https://doi.org/10.1111/1753-0407.12915 DB - PRIME DP - Unbound Medicine ER -
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