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Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties.
J Basic Clin Physiol Pharmacol. 2018 Dec 20; 30(2):251-257.JB

Abstract

Background Based on our previous ethnobotanical survey, the non-investigated Saharan plant Anabasis aretioides Coss. & Moq., growing in the region of Errachidia, was selected for pharmacological investigation. In Moroccan traditional medicine, A. aretioides is being used for diabetes treatment. Thus, the current work aims at evaluating the antidiabetic, antioxidant, and antibacterial activities of the plant in relation to the digestive tract. Methods The different parts of the plant (aerial parts, roots, seeds) were extracted with methanol (MeOH) and screened in enzymatic assays for their inhibitory potential against α-amylase and α-glucosidase, as well as antioxidant and antibacterial activities. Furthermore, the phenolic compounds were analyzed using HPLC-DAD-QTOF-MS. Results The MeOH extracts of A. aretioides aerial parts, roots, and seeds, respectively, inhibited α-amylase (IC50 of 3148.07 μg/mL, 2440.20 μg/mL, 3395.71 μg/mL) and α-glucosidase (IC50 of 2940.59 μg/mL, 3521.81 μg/mL, 3393.83 μg/mL). Moreover, compared to aerial parts and seeds, the plant roots exhibited higher antioxidant capacity and a potent reducing power. In resazurin microplate assay, the plant parts displayed a minimal inhibitory concentration (MIC) ranging from 7.81 mg/mL to 31.25 mg/mL. Chemical analysis revealed 25 phenolic compounds, with chlorogenic acid as the main phenolic compound in the aerial parts, hesperidin in roots, and quercitrin in seeds. Conclusion Anabasis aretioides cited for treatment of diabetes shows promising antioxidant and antibacterial properties, as well as an ability to inhibit digestive enzyme, including α-amylase and α-glucosidase. Thus, our results explain in part the traditional use of this Saharan medicine and open doors for further in vivo mechanistic and functional studies.

Authors+Show Affiliations

Laboratory of Biochemistry, Biotechnology, Health and Environment, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Mohammed V University in Rabat, Rabat, Morocco.Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Mohammed V University in Rabat, Rabat, Morocco. Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel, Brussels, Belgium.Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco.Faculté des Sciences Kénitra, Université Ibn Tofail, Rabat, Morocco.Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Mohammed V University in Rabat, Rabat, Morocco.Laboratory of Biochemistry, Biotechnology, Health and Environment, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.Laboratory of Electrochemistry and Materials Environment, Department of Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.Laboratory of Electrochemistry and Materials Environment, Department of Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.Laboratory of Genetics, Neuroendocrinology and Biotechnology, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Mohammed V University in Rabat, Rabat, Morocco.Laboratory of Biochemistry, Biotechnology, Health and Environment, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30864419

Citation

Berrani, Assia, et al. "Anabasis Aretioides Coss. & Moq. Phenolic Compounds Exhibit in Vitro Hypoglycemic, Antioxidant and Antipathogenic Properties." Journal of Basic and Clinical Physiology and Pharmacology, vol. 30, no. 2, 2018, pp. 251-257.
Berrani A, Marmouzi I, Kharbach M, et al. Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties. J Basic Clin Physiol Pharmacol. 2018;30(2):251-257.
Berrani, A., Marmouzi, I., Kharbach, M., Bouyahya, A., El Hamdani, M., El Jemli, M., Lrhorfi, A., Benassaoui, H., Zouarhi, M., My Larbi, O., El Abbes Faouzi, M., & Bengueddour, R. (2018). Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties. Journal of Basic and Clinical Physiology and Pharmacology, 30(2), 251-257. https://doi.org/10.1515/jbcpp-2018-0154
Berrani A, et al. Anabasis Aretioides Coss. & Moq. Phenolic Compounds Exhibit in Vitro Hypoglycemic, Antioxidant and Antipathogenic Properties. J Basic Clin Physiol Pharmacol. 2018 Dec 20;30(2):251-257. PubMed PMID: 30864419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties. AU - Berrani,Assia, AU - Marmouzi,Ilias, AU - Kharbach,Mourad, AU - Bouyahya,Abdelhakim, AU - El Hamdani,Maha, AU - El Jemli,Meryem, AU - Lrhorfi,Aicha, AU - Benassaoui,Hayat, AU - Zouarhi,Meryem, AU - My Larbi,Ouahidi, AU - El Abbes Faouzi,My, AU - Bengueddour,Rachid, Y1 - 2018/12/20/ PY - 2018/08/18/received PY - 2018/11/30/accepted PY - 2019/3/14/pubmed PY - 2019/7/25/medline PY - 2019/3/14/entrez KW - Anabasis aretioides Coss. & Moq. KW - antimicrobial KW - antioxidant KW - digestive enzyme KW - phenolic SP - 251 EP - 257 JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 30 IS - 2 N2 - Background Based on our previous ethnobotanical survey, the non-investigated Saharan plant Anabasis aretioides Coss. & Moq., growing in the region of Errachidia, was selected for pharmacological investigation. In Moroccan traditional medicine, A. aretioides is being used for diabetes treatment. Thus, the current work aims at evaluating the antidiabetic, antioxidant, and antibacterial activities of the plant in relation to the digestive tract. Methods The different parts of the plant (aerial parts, roots, seeds) were extracted with methanol (MeOH) and screened in enzymatic assays for their inhibitory potential against α-amylase and α-glucosidase, as well as antioxidant and antibacterial activities. Furthermore, the phenolic compounds were analyzed using HPLC-DAD-QTOF-MS. Results The MeOH extracts of A. aretioides aerial parts, roots, and seeds, respectively, inhibited α-amylase (IC50 of 3148.07 μg/mL, 2440.20 μg/mL, 3395.71 μg/mL) and α-glucosidase (IC50 of 2940.59 μg/mL, 3521.81 μg/mL, 3393.83 μg/mL). Moreover, compared to aerial parts and seeds, the plant roots exhibited higher antioxidant capacity and a potent reducing power. In resazurin microplate assay, the plant parts displayed a minimal inhibitory concentration (MIC) ranging from 7.81 mg/mL to 31.25 mg/mL. Chemical analysis revealed 25 phenolic compounds, with chlorogenic acid as the main phenolic compound in the aerial parts, hesperidin in roots, and quercitrin in seeds. Conclusion Anabasis aretioides cited for treatment of diabetes shows promising antioxidant and antibacterial properties, as well as an ability to inhibit digestive enzyme, including α-amylase and α-glucosidase. Thus, our results explain in part the traditional use of this Saharan medicine and open doors for further in vivo mechanistic and functional studies. SN - 2191-0286 UR - https://www.unboundmedicine.com/medline/citation/30864419/Anabasis_aretioides_Coss__&_Moq__phenolic_compounds_exhibit_in_vitro_hypoglycemic_antioxidant_and_antipathogenic_properties_ L2 - https://www.degruyter.com/document/doi/10.1515/jbcpp-2018-0154 DB - PRIME DP - Unbound Medicine ER -