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"Inactive" ingredients in oral medications.
Sci Transl Med. 2019 03 13; 11(483)ST

Abstract

Oral forms of medications contain "inactive" ingredients to enhance their physical properties. Using data analytics, we characterized the abundance and complexity of inactive ingredients in approved medications. A majority of medications contain ingredients that could cause adverse reactions, underscoring the need to maximize the tolerability and safety of medications and their inactive ingredients.

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Authors+Show Affiliations

Reker D
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. MIT-IBM Watson AI Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Blum SM
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Steiger C
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. MIT-IBM Watson AI Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Anger KE
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sommer JM
Investigational Drug Service, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Fanikos J
Investigational Drug Service, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Traverso G
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ctraverso@bwh.harvard.edu cgt20@mit.edu. Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. MIT-IBM Watson AI Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

MeSH

Administration, OralAnimalsDrug CompoundingExcipientsHumansPharmaceutical Preparations

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30867323

Citation

Reker, Daniel, et al. ""Inactive" Ingredients in Oral Medications." Science Translational Medicine, vol. 11, no. 483, 2019.
Reker D, Blum SM, Steiger C, et al. "Inactive" ingredients in oral medications. Sci Transl Med. 2019;11(483).
Reker, D., Blum, S. M., Steiger, C., Anger, K. E., Sommer, J. M., Fanikos, J., & Traverso, G. (2019). "Inactive" ingredients in oral medications. Science Translational Medicine, 11(483). https://doi.org/10.1126/scitranslmed.aau6753
Reker D, et al. "Inactive" Ingredients in Oral Medications. Sci Transl Med. 2019 03 13;11(483) PubMed PMID: 30867323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "Inactive" ingredients in oral medications. AU - Reker,Daniel, AU - Blum,Steven M, AU - Steiger,Christoph, AU - Anger,Kevin E, AU - Sommer,Jamie M, AU - Fanikos,John, AU - Traverso,Giovanni, PY - 2018/07/04/received PY - 2019/02/22/accepted PY - 2019/3/15/entrez PY - 2019/3/15/pubmed PY - 2020/2/23/medline JF - Science translational medicine JO - Sci Transl Med VL - 11 IS - 483 N2 - Oral forms of medications contain "inactive" ingredients to enhance their physical properties. Using data analytics, we characterized the abundance and complexity of inactive ingredients in approved medications. A majority of medications contain ingredients that could cause adverse reactions, underscoring the need to maximize the tolerability and safety of medications and their inactive ingredients. SN - 1946-6242 UR - https://www.unboundmedicine.com/medline/citation/30867323/"Inactive"_ingredients_in_oral_medications. DB - PRIME DP - Unbound Medicine ER -