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Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia.
Epidemiol Infect. 2019 01; 147:e77.EI

Abstract

Our objective was to determine the frequency of zika (ZIKV), chikungunya (CHIKV) and dengue (DENV) virus coinfection and describe the mortality cases that occurred during the epidemiologic surveillance of the ZIKV epidemic in Colombia. We analysed all cases of suspected ZIKV infection that were reported to the National Institute of Health (October 2015-December 2016). DENV, CHIKV and ZIKV RNA were detected in serum or tissue samples using polymerase chain reaction assay. Medical records of the fatal cases were reviewed. We identified that 23 871 samples were processed. The frequency of viral agents was 439 (1.84%) for DENV, 257 (1.07%) for CHIKV and 10118 (42.38%) for ZIKV. Thirty-four (0.14%) cases of coinfection were identified. The CHIKV-ZIKV coinfection was present in 28 cases (82.3%), DENV-CHIKV in three (8.8%) and DENV-ZIKV in three (8.8%). Seven (20.6%) coinfection cases were fatal (two DENV-CHIKV cases and five CHIKV-ZIKV cases). Two cases were foetal deaths and the others were related to neurological syndrome and sepsis. In conclusion, the frequency of arbovirus coinfection during epidemic of ZIKV was low, and CHIKV-ZIKV coinfection was the most common. Mortality was high among coinfection patients. The role of each virus in the mortality cases of coinfection warrants further studies.

Authors+Show Affiliations

Department of Research in Public Health,National Institute of Health,Bogota D.C.,Colombia.Department of Public Health, Health Sciences Division,Universidad del Norte,Barranquilla,Colombia.Department of Public Health, Health Sciences Division,Universidad del Norte,Barranquilla,Colombia.Department of Network in Public Health,National Institute of Health,Bogota D.C.,Colombia.Department of Network in Public Health,National Institute of Health,Bogota D.C.,Colombia.Department of Network in Public Health,National Institute of Health,Bogota D.C.,Colombia.Department of Public Health Surveillance,National Institute of Health,Bogota D.C.,Colombia.Department of Network in Public Health,National Institute of Health,Bogota D.C.,Colombia.Department of Public Health Surveillance,National Institute of Health,Bogota D.C.,Colombia.Institute of Public Health, Javeriana University,Bogotá D.C.,Colombia.Department of Network in Public Health,National Institute of Health,Bogota D.C.,Colombia.General Director,National Institute of Health,Bogota D.C.,Colombia.Department of Research in Public Health,National Institute of Health,Bogota D.C.,Colombia.Department of Medicine, Health Sciences Division,Universidad del Norte and Hospital Universidad del Norte,Barranquilla,Colombia.Department of Medicine, Health Sciences Division,Universidad del Norte and Hospital Universidad del Norte,Barranquilla,Colombia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30869010

Citation

Mercado-Reyes, Marcela, et al. "Dengue, Chikungunya and Zika Virus Coinfection: Results of the National Surveillance During the Zika Epidemic in Colombia." Epidemiology and Infection, vol. 147, 2019, pp. e77.
Mercado-Reyes M, Acosta-Reyes J, Navarro-Lechuga E, et al. Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia. Epidemiol Infect. 2019;147:e77.
Mercado-Reyes, M., Acosta-Reyes, J., Navarro-Lechuga, E., Corchuelo, S., Rico, A., Parra, E., Tolosa, N., Pardo, L., González, M., Martìn-Rodriguez-Hernández, J., Karime-Osorio, L., Ospina-Martinez, M., Rodriguez-Perea, H., Del Rio-Pertuz, G., & Viasus, D. (2019). Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia. Epidemiology and Infection, 147, e77. https://doi.org/10.1017/S095026881800359X
Mercado-Reyes M, et al. Dengue, Chikungunya and Zika Virus Coinfection: Results of the National Surveillance During the Zika Epidemic in Colombia. Epidemiol Infect. 2019;147:e77. PubMed PMID: 30869010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia. AU - Mercado-Reyes,Marcela, AU - Acosta-Reyes,Jorge, AU - Navarro-Lechuga,Edgar, AU - Corchuelo,Sherill, AU - Rico,Angélica, AU - Parra,Edgar, AU - Tolosa,Natalia, AU - Pardo,Lissethe, AU - González,Maritza, AU - Martìn-Rodriguez-Hernández,Jorge, AU - Karime-Osorio,Luz, AU - Ospina-Martinez,Martha, AU - Rodriguez-Perea,Helena, AU - Del Rio-Pertuz,Gaspar, AU - Viasus,Diego, PY - 2019/3/15/entrez PY - 2019/3/15/pubmed PY - 2020/3/28/medline KW - Coinfection KW - chikungunya KW - dengue KW - mortality KW - zika SP - e77 EP - e77 JF - Epidemiology and infection JO - Epidemiol Infect VL - 147 N2 - Our objective was to determine the frequency of zika (ZIKV), chikungunya (CHIKV) and dengue (DENV) virus coinfection and describe the mortality cases that occurred during the epidemiologic surveillance of the ZIKV epidemic in Colombia. We analysed all cases of suspected ZIKV infection that were reported to the National Institute of Health (October 2015-December 2016). DENV, CHIKV and ZIKV RNA were detected in serum or tissue samples using polymerase chain reaction assay. Medical records of the fatal cases were reviewed. We identified that 23 871 samples were processed. The frequency of viral agents was 439 (1.84%) for DENV, 257 (1.07%) for CHIKV and 10118 (42.38%) for ZIKV. Thirty-four (0.14%) cases of coinfection were identified. The CHIKV-ZIKV coinfection was present in 28 cases (82.3%), DENV-CHIKV in three (8.8%) and DENV-ZIKV in three (8.8%). Seven (20.6%) coinfection cases were fatal (two DENV-CHIKV cases and five CHIKV-ZIKV cases). Two cases were foetal deaths and the others were related to neurological syndrome and sepsis. In conclusion, the frequency of arbovirus coinfection during epidemic of ZIKV was low, and CHIKV-ZIKV coinfection was the most common. Mortality was high among coinfection patients. The role of each virus in the mortality cases of coinfection warrants further studies. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/30869010/Dengue_chikungunya_and_zika_virus_coinfection:_results_of_the_national_surveillance_during_the_zika_epidemic_in_Colombia_ L2 - https://www.cambridge.org/core/product/identifier/S095026881800359X/type/journal_article DB - PRIME DP - Unbound Medicine ER -