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[Hepatitis E virus infection].
Rev Prat. 2018 Mar; 68(3):286-290.RP

Abstract

Hepatitis E virus infection. Hepatitis E virus (HEV) infection is currently recognized as an endemic pathogen in developed countries, especially in Western Europe. In these regions, HEV is a zoonotic agent and is mainly transmitted by the consumption of under cooked pig or game meat. HEV infection is generally a self-limiting illness in immunocompetent subjects. Conversely, in immunocompromised patients, i.e., solid-organ-transplant recipients, human immunodeficiency virus-infected patients with a low CD4 cell count, hematological patients receiving chemotherapy, and patients given immune suppressive therapy, HEV can lead to chronic hepatitis and cirrhosis. In this case, if viral replication persists despite immunosuppressive regimen decrease, ribavirin therapy has to be initiated to allow viral clearance. Recently, some extra-hepatic manifestations associated with HEV infection have been observed, suggesting a broader tropism than initially considered.

Authors+Show Affiliations

Marion O
Département de néphrologie et transplantation d'organes, hôpital Rangueil. Inserm UMR1043, centre de physiopathologie de Toulouse-Purpan.
Izopet J
Centre national de référence Hépatite E, laboratoire de virologie, hôpital Purpan. Inserm UMR1043, centre de physiopathologie de Toulouse-Purpan. Université Toulouse-III Paul-Sabatier CHU de Toulouse, Toulouse, France.
Kamar N
Département de néphrologie et transplantation d'organes, hôpital Rangueil. Inserm UMR1043, centre de physiopathologie de Toulouse-Purpan. Université Toulouse-III Paul-Sabatier CHU de Toulouse, Toulouse, France.

MeSH

AnimalsEuropeHepatitis EHepatitis E virusHumansImmunocompromised HostRibavirinSwine

Pub Type(s)

Journal Article

Language

fre

PubMed ID

30869287

Citation

Marion, Olivier, et al. "[Hepatitis E Virus Infection]." La Revue Du Praticien, vol. 68, no. 3, 2018, pp. 286-290.
Marion O, Izopet J, Kamar N. [Hepatitis E virus infection]. Rev Prat. 2018;68(3):286-290.
Marion, O., Izopet, J., & Kamar, N. (2018). [Hepatitis E virus infection]. La Revue Du Praticien, 68(3), 286-290.
Marion O, Izopet J, Kamar N. [Hepatitis E Virus Infection]. Rev Prat. 2018;68(3):286-290. PubMed PMID: 30869287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hepatitis E virus infection]. AU - Marion,Olivier, AU - Izopet,Jacques, AU - Kamar,Nassim, PY - 2019/3/15/entrez PY - 2019/3/15/pubmed PY - 2019/5/21/medline KW - Hepatitis E virus infection SP - 286 EP - 290 JF - La Revue du praticien JO - Rev Prat VL - 68 IS - 3 N2 - Hepatitis E virus infection. Hepatitis E virus (HEV) infection is currently recognized as an endemic pathogen in developed countries, especially in Western Europe. In these regions, HEV is a zoonotic agent and is mainly transmitted by the consumption of under cooked pig or game meat. HEV infection is generally a self-limiting illness in immunocompetent subjects. Conversely, in immunocompromised patients, i.e., solid-organ-transplant recipients, human immunodeficiency virus-infected patients with a low CD4 cell count, hematological patients receiving chemotherapy, and patients given immune suppressive therapy, HEV can lead to chronic hepatitis and cirrhosis. In this case, if viral replication persists despite immunosuppressive regimen decrease, ribavirin therapy has to be initiated to allow viral clearance. Recently, some extra-hepatic manifestations associated with HEV infection have been observed, suggesting a broader tropism than initially considered. SN - 0035-2640 UR - https://www.unboundmedicine.com/medline/citation/30869287/[Hepatitis_E_virus_infection]_ DB - PRIME DP - Unbound Medicine ER -