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Incubation period and risk factors support sexual transmission of bacterial vaginosis in women who have sex with women.
Sex Transm Infect. 2019 11; 95(7):511-515.ST

Abstract

OBJECTIVE

The epidemiology of bacterial vaginosis (BV) favours sexual transmission of BV-associated bacteria. We examined incubation period and risk factors for incident BV (iBV) in a prospective study of women who have sex with women (WSW).

METHODS

Using daily self-collected vaginal swabs, WSW with normal vaginal microbiota (no Amsel criteria and a Nugent score of 0-3) were followed for 90 days or until iBV (Nugent score 7-10 on at least 2-3 consecutive days). Daily diaries of sexual activity and menses were completed. Time to iBV was estimated. Accounting for differing lengths of follow-up and age, rates of sexual activities (per 100 person-days (pd)) were compared according to iBV status. The relationship between menses and iBV was also investigated.

RESULTS

Of the 36 WSW, the mean age was 30 years (SD 8) and 92% were African American. The probability of iBV at 30 and 60 days was 20% (SD 7%) and 36% (SD 8%), respectively; 14 (39%) developed iBV by 90 days. In WSW with iBV versus those without iBV, the relative rate of any sexual activity prior to iBV was 40% higher (20.4 vs 14.6 per 100 pd; p=0.010), sex with a woman was 38% higher (14.3 vs 10.3 per 100 pd; p=0.038), digital-vaginal sex was 57% higher (14.3 vs 9.1 per 100 pd; p=0.005) and digital-anal sex was 5.6 times higher (2.9 vs 0.5 per 100 pd; p<0.001). iBV was more likely for those WSW with menses in the prior 2 days as compared with those without recent menses (HR 3.4; p=0.029). Sexual activity occurred in 93% WSW at a median of 4 days (95% CI 2 to 6) prior to iBV.

CONCLUSION

iBV was common and associated with sexual activity in this cohort of predominantly African American WSW. An incubation period of 4 days is consistent with other bacterial STIs.

Authors+Show Affiliations

Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA cmuzny@uabmc.edu.Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30872415

Citation

Muzny, Christina Ann, et al. "Incubation Period and Risk Factors Support Sexual Transmission of Bacterial Vaginosis in Women Who Have Sex With Women." Sexually Transmitted Infections, vol. 95, no. 7, 2019, pp. 511-515.
Muzny CA, Lensing SY, Aaron KJ, et al. Incubation period and risk factors support sexual transmission of bacterial vaginosis in women who have sex with women. Sex Transm Infect. 2019;95(7):511-515.
Muzny, C. A., Lensing, S. Y., Aaron, K. J., & Schwebke, J. R. (2019). Incubation period and risk factors support sexual transmission of bacterial vaginosis in women who have sex with women. Sexually Transmitted Infections, 95(7), 511-515. https://doi.org/10.1136/sextrans-2018-053824
Muzny CA, et al. Incubation Period and Risk Factors Support Sexual Transmission of Bacterial Vaginosis in Women Who Have Sex With Women. Sex Transm Infect. 2019;95(7):511-515. PubMed PMID: 30872415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incubation period and risk factors support sexual transmission of bacterial vaginosis in women who have sex with women. AU - Muzny,Christina Ann, AU - Lensing,Shelly Y, AU - Aaron,Kristal J, AU - Schwebke,Jane R, Y1 - 2019/03/14/ PY - 2018/08/26/received PY - 2018/12/18/revised PY - 2019/02/16/accepted PY - 2019/3/16/pubmed PY - 2020/2/13/medline PY - 2019/3/16/entrez KW - bacterial vaginosis KW - lesbians KW - women SP - 511 EP - 515 JF - Sexually transmitted infections JO - Sex Transm Infect VL - 95 IS - 7 N2 - OBJECTIVE: The epidemiology of bacterial vaginosis (BV) favours sexual transmission of BV-associated bacteria. We examined incubation period and risk factors for incident BV (iBV) in a prospective study of women who have sex with women (WSW). METHODS: Using daily self-collected vaginal swabs, WSW with normal vaginal microbiota (no Amsel criteria and a Nugent score of 0-3) were followed for 90 days or until iBV (Nugent score 7-10 on at least 2-3 consecutive days). Daily diaries of sexual activity and menses were completed. Time to iBV was estimated. Accounting for differing lengths of follow-up and age, rates of sexual activities (per 100 person-days (pd)) were compared according to iBV status. The relationship between menses and iBV was also investigated. RESULTS: Of the 36 WSW, the mean age was 30 years (SD 8) and 92% were African American. The probability of iBV at 30 and 60 days was 20% (SD 7%) and 36% (SD 8%), respectively; 14 (39%) developed iBV by 90 days. In WSW with iBV versus those without iBV, the relative rate of any sexual activity prior to iBV was 40% higher (20.4 vs 14.6 per 100 pd; p=0.010), sex with a woman was 38% higher (14.3 vs 10.3 per 100 pd; p=0.038), digital-vaginal sex was 57% higher (14.3 vs 9.1 per 100 pd; p=0.005) and digital-anal sex was 5.6 times higher (2.9 vs 0.5 per 100 pd; p<0.001). iBV was more likely for those WSW with menses in the prior 2 days as compared with those without recent menses (HR 3.4; p=0.029). Sexual activity occurred in 93% WSW at a median of 4 days (95% CI 2 to 6) prior to iBV. CONCLUSION: iBV was common and associated with sexual activity in this cohort of predominantly African American WSW. An incubation period of 4 days is consistent with other bacterial STIs. SN - 1472-3263 UR - https://www.unboundmedicine.com/medline/citation/30872415/Incubation_period_and_risk_factors_support_sexual_transmission_of_bacterial_vaginosis_in_women_who_have_sex_with_women_ DB - PRIME DP - Unbound Medicine ER -