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The correlation between fatty liver disease and chronic kidney disease.
J Formos Med Assoc. 2020 Jan; 119(1 Pt 1):42-50.JF

Abstract

BACKGROUND/PURPOSE

The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study.

METHODS

We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2.

RESULTS

Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954-1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513-3.448, p < 0.001).

CONCLUSION

NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan.Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Gastroenterology, Department of Medicine, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan. Electronic address: prudent260@yahoo.com.tw.Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Healthcare and Services, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: cwsu2@vghtpe.gov.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30876789

Citation

Chen, Po-Chun, et al. "The Correlation Between Fatty Liver Disease and Chronic Kidney Disease." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 119, no. 1 Pt 1, 2020, pp. 42-50.
Chen PC, Kao WY, Cheng YL, et al. The correlation between fatty liver disease and chronic kidney disease. J Formos Med Assoc. 2020;119(1 Pt 1):42-50.
Chen, P. C., Kao, W. Y., Cheng, Y. L., Wang, Y. J., Hou, M. C., Wu, J. C., & Su, C. W. (2020). The correlation between fatty liver disease and chronic kidney disease. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 119(1 Pt 1), 42-50. https://doi.org/10.1016/j.jfma.2019.02.010
Chen PC, et al. The Correlation Between Fatty Liver Disease and Chronic Kidney Disease. J Formos Med Assoc. 2020;119(1 Pt 1):42-50. PubMed PMID: 30876789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The correlation between fatty liver disease and chronic kidney disease. AU - Chen,Po-Chun, AU - Kao,Wei-Yu, AU - Cheng,Yuan-Lung, AU - Wang,Yuan-Jen, AU - Hou,Ming-Chih, AU - Wu,Jaw-Ching, AU - Su,Chien-Wei, Y1 - 2019/03/12/ PY - 2018/09/04/received PY - 2018/11/15/revised PY - 2019/02/21/accepted PY - 2019/3/17/pubmed PY - 2020/7/2/medline PY - 2019/3/17/entrez KW - Kidney diseases KW - Liver fibrosis KW - Non-alcoholic fatty liver disease SP - 42 EP - 50 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 119 IS - 1 Pt 1 N2 - BACKGROUND/PURPOSE: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. METHODS: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. RESULTS: Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954-1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513-3.448, p < 0.001). CONCLUSION: NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/30876789/The_correlation_between_fatty_liver_disease_and_chronic_kidney_disease_ DB - PRIME DP - Unbound Medicine ER -