Tags

Type your tag names separated by a space and hit enter

Cannabimimetic plants: are they new cannabinoidergic modulators?
Planta 2019; 249(6):1681-1694P

Abstract

MAIN CONCLUSION

Phytochemicals and secondary metabolites able to interact with the endocannabinoid system (Cannabimimetics) have been recently described in a broad range of plants and fruits. These findings can open new alternative avenues to explore for the development of novel therapeutic compounds. The cannabinoids regulate many physiological and pathological functions in both animals and plants. Cannabis sativa is the main plant that produces phytocannabinoids inside resins capable to defend the plant from the aggression of parasites and herbivores. Animals produce anandamide and 2-arachidonoyl glycerol, which thanks to binding with main receptors such as type-1 cannabinoid receptor (CB1R) and the type-2 cannabinoid receptor (CB2R) are involved in inflammation processes and several brain functions. Endogenous cannabinoids, enzymes for synthesis and degradation of cannabinoids, and CB1R and CB2R constitute the endocannabinoid system (ECS). Other plants can produce cannabinoid-like molecules such as perrottetinene extracted from Radula perrottetii, or anandamide and 2-arachidonoyl glycerol extracted from some bryophytes. Moreover, several other secondary metabolites can also interact with the ECS of animals and take the name of cannabimimetics. These phytoextracts not derived from Cannabis sativa can act as receptor agonists or antagonist, or enzyme inhibitors of ECS and can be involved in the inflammation, oxidative stress, cancer, and neuroprotection. Finally, given the evolutionary heterogeneity of the cannabimimetic plants, some authors speculated on the fascinating thesis of the evolutionary convergence between plants and animals regarding biological functions of ECS. The review aims to provide a critical and complete assessment of the botanical, chemical and therapeutic aspects of cannabimimetic plants to evaluate their spread in the world and medicinal potentiality.

Authors+Show Affiliations

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Blickagången 16, Huddinge, Sweden.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy. andrea.mastinu@unibs.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30877436

Citation

Kumar, Amit, et al. "Cannabimimetic Plants: Are They New Cannabinoidergic Modulators?" Planta, vol. 249, no. 6, 2019, pp. 1681-1694.
Kumar A, Premoli M, Aria F, et al. Cannabimimetic plants: are they new cannabinoidergic modulators? Planta. 2019;249(6):1681-1694.
Kumar, A., Premoli, M., Aria, F., Bonini, S. A., Maccarinelli, G., Gianoncelli, A., ... Mastinu, A. (2019). Cannabimimetic plants: are they new cannabinoidergic modulators? Planta, 249(6), pp. 1681-1694. doi:10.1007/s00425-019-03138-x.
Kumar A, et al. Cannabimimetic Plants: Are They New Cannabinoidergic Modulators. Planta. 2019;249(6):1681-1694. PubMed PMID: 30877436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabimimetic plants: are they new cannabinoidergic modulators? AU - Kumar,Amit, AU - Premoli,Marika, AU - Aria,Francesca, AU - Bonini,Sara Anna, AU - Maccarinelli,Giuseppina, AU - Gianoncelli,Alessandra, AU - Memo,Maurizio, AU - Mastinu,Andrea, Y1 - 2019/03/15/ PY - 2018/12/14/received PY - 2019/03/12/accepted PY - 2019/3/17/pubmed PY - 2019/5/21/medline PY - 2019/3/17/entrez SP - 1681 EP - 1694 JF - Planta JO - Planta VL - 249 IS - 6 N2 - MAIN CONCLUSION: Phytochemicals and secondary metabolites able to interact with the endocannabinoid system (Cannabimimetics) have been recently described in a broad range of plants and fruits. These findings can open new alternative avenues to explore for the development of novel therapeutic compounds. The cannabinoids regulate many physiological and pathological functions in both animals and plants. Cannabis sativa is the main plant that produces phytocannabinoids inside resins capable to defend the plant from the aggression of parasites and herbivores. Animals produce anandamide and 2-arachidonoyl glycerol, which thanks to binding with main receptors such as type-1 cannabinoid receptor (CB1R) and the type-2 cannabinoid receptor (CB2R) are involved in inflammation processes and several brain functions. Endogenous cannabinoids, enzymes for synthesis and degradation of cannabinoids, and CB1R and CB2R constitute the endocannabinoid system (ECS). Other plants can produce cannabinoid-like molecules such as perrottetinene extracted from Radula perrottetii, or anandamide and 2-arachidonoyl glycerol extracted from some bryophytes. Moreover, several other secondary metabolites can also interact with the ECS of animals and take the name of cannabimimetics. These phytoextracts not derived from Cannabis sativa can act as receptor agonists or antagonist, or enzyme inhibitors of ECS and can be involved in the inflammation, oxidative stress, cancer, and neuroprotection. Finally, given the evolutionary heterogeneity of the cannabimimetic plants, some authors speculated on the fascinating thesis of the evolutionary convergence between plants and animals regarding biological functions of ECS. The review aims to provide a critical and complete assessment of the botanical, chemical and therapeutic aspects of cannabimimetic plants to evaluate their spread in the world and medicinal potentiality. SN - 1432-2048 UR - https://www.unboundmedicine.com/medline/citation/30877436/Cannabimimetic_plants:_are_they_new_cannabinoidergic_modulators L2 - https://dx.doi.org/10.1007/s00425-019-03138-x DB - PRIME DP - Unbound Medicine ER -