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Antithrombotics from the Sea: Polysaccharides and Beyond.
Mar Drugs. 2019 Mar 16; 17(3)MD

Abstract

Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect.

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Authors+Show Affiliations

Carvalhal F
LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. francisca.carvalhal@gmail.com. CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, 4450-208 Matosinhos, Portugal. francisca.carvalhal@gmail.com.
Cristelo RR
LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. ricardorc@live.com.pt.
Resende DISP
LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. dresende@ff.up.pt. CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, 4450-208 Matosinhos, Portugal. dresende@ff.up.pt.
Pinto MMM
LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt. CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, 4450-208 Matosinhos, Portugal. madalena@ff.up.pt.
Sousa E
LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. esousa@ff.up.pt. CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, 4450-208 Matosinhos, Portugal. esousa@ff.up.pt.
Correia-da-Silva M
LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. m_correiadasilva@ff.up.pt. CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, 4450-208 Matosinhos, Portugal. m_correiadasilva@ff.up.pt.

MeSH

AnimalsAnticoagulantsAquatic OrganismsFibrinolytic AgentsPolysaccharidesStructure-Activity Relationship

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30884850

Citation

Carvalhal, Francisca, et al. "Antithrombotics From the Sea: Polysaccharides and Beyond." Marine Drugs, vol. 17, no. 3, 2019.
Carvalhal F, Cristelo RR, Resende DISP, et al. Antithrombotics from the Sea: Polysaccharides and Beyond. Mar Drugs. 2019;17(3).
Carvalhal, F., Cristelo, R. R., Resende, D. I. S. P., Pinto, M. M. M., Sousa, E., & Correia-da-Silva, M. (2019). Antithrombotics from the Sea: Polysaccharides and Beyond. Marine Drugs, 17(3). https://doi.org/10.3390/md17030170
Carvalhal F, et al. Antithrombotics From the Sea: Polysaccharides and Beyond. Mar Drugs. 2019 Mar 16;17(3) PubMed PMID: 30884850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antithrombotics from the Sea: Polysaccharides and Beyond. AU - Carvalhal,Francisca, AU - Cristelo,Ricardo R, AU - Resende,Diana I S P, AU - Pinto,Madalena M M, AU - Sousa,Emília, AU - Correia-da-Silva,Marta, Y1 - 2019/03/16/ PY - 2019/01/31/received PY - 2019/03/01/revised PY - 2019/03/13/accepted PY - 2019/3/20/entrez PY - 2019/3/20/pubmed PY - 2019/7/30/medline KW - anticoagulant KW - antiplatelet KW - antithrombotic KW - glycosaminoglycans KW - marine-derived KW - polysaccharide KW - sulfated fucans KW - sulfated galactans JF - Marine drugs JO - Mar Drugs VL - 17 IS - 3 N2 - Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/30884850/Antithrombotics_from_the_Sea:_Polysaccharides_and_Beyond_ DB - PRIME DP - Unbound Medicine ER -